FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 9412

FusionGeneSummary for DCDC2_MRS2

check button Fusion gene summary
Fusion gene informationFusion gene name: DCDC2_MRS2
Fusion gene ID: 9412
HgeneTgene
Gene symbol

DCDC2

MRS2

Gene ID

51473

57380

Gene namedoublecortin domain containing 2MRS2, magnesium transporter
SynonymsDCDC2A|DFNB66|NPHP19|NSC|RU2|RU2SHPT|MRS2L
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptiondoublecortin domain-containing protein 2magnesium transporter MRS2 homolog, mitochondrialMRS2-like proteinMRS2-like, magnesium homeostasis factorputative magnesium transporter
Modification date2018052320180523
UniProtAcc

Q9UHG0

Q9HD23

Ensembl transtripts involved in fusion geneENST00000378454, ENST00000378450, 
ENST00000274747, ENST00000543597, 
ENST00000535061, ENST00000483634, 
ENST00000378353, ENST00000378386, 
ENST00000443868, 
Fusion gene scores* DoF score2 X 2 X 3=124 X 3 X 3=36
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DCDC2 [Title/Abstract] AND MRS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-4Z-AA7R-01ADCDC2chr6

24353797

-MRS2chr6

24423165

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000378454ENST00000274747DCDC2chr6

24353797

-MRS2chr6

24423165

+
5CDS-3UTRENST00000378454ENST00000543597DCDC2chr6

24353797

-MRS2chr6

24423165

+
5CDS-3UTRENST00000378454ENST00000535061DCDC2chr6

24353797

-MRS2chr6

24423165

+
5CDS-intronENST00000378454ENST00000483634DCDC2chr6

24353797

-MRS2chr6

24423165

+
5CDS-intronENST00000378454ENST00000378353DCDC2chr6

24353797

-MRS2chr6

24423165

+
5CDS-intronENST00000378454ENST00000378386DCDC2chr6

24353797

-MRS2chr6

24423165

+
5CDS-intronENST00000378454ENST00000443868DCDC2chr6

24353797

-MRS2chr6

24423165

+
intron-3UTRENST00000378450ENST00000274747DCDC2chr6

24353797

-MRS2chr6

24423165

+
intron-3UTRENST00000378450ENST00000543597DCDC2chr6

24353797

-MRS2chr6

24423165

+
intron-3UTRENST00000378450ENST00000535061DCDC2chr6

24353797

-MRS2chr6

24423165

+
intron-intronENST00000378450ENST00000483634DCDC2chr6

24353797

-MRS2chr6

24423165

+
intron-intronENST00000378450ENST00000378353DCDC2chr6

24353797

-MRS2chr6

24423165

+
intron-intronENST00000378450ENST00000378386DCDC2chr6

24353797

-MRS2chr6

24423165

+
intron-intronENST00000378450ENST00000443868DCDC2chr6

24353797

-MRS2chr6

24423165

+

Top

FusionProtFeatures for DCDC2_MRS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCDC2

Q9UHG0

MRS2

Q9HD23

Protein that plays a role in the inhibition of canonicalWnt signaling pathway (PubMed:25557784). May be involved inneuronal migration during development of the cerebral neocortex(By similarity). Involved in the control of ciliogenesis andciliary length (PubMed:25601850, PubMed:27319779).{ECO:0000250|UniProtKB:D3ZR10, ECO:0000269|PubMed:25557784,ECO:0000269|PubMed:25601850, ECO:0000269|PubMed:27319779}. Magnesium transporter that mediates the influx ofmagnesium into the mitochondrial matrix (PubMed:11401429,PubMed:18384665). Required for normal expression of themitochondrial respiratory complex I subunits (PubMed:18384665).{ECO:0000269|PubMed:11401429, ECO:0000269|PubMed:18384665}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DCDC2_MRS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DCDC2_MRS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCDC2APP, NIF3L1, MRFAP1, DCTN1MRS2RIC3, RSRP1, CACNG4, SLC39A4, P2RY12, LUC7L, KCMF1, B3GALT2, CHST8, INTS4P2, LPAR1, UBR5, ZNF133, SYP, NOL9, TSPYL1, TBC1D15, MRPL35, ZNF747, TBC1D9, VTN, MINPP1, SPPL2B, BZW2, AURKAIP1, FEZ1, JPH4, NGEF, IPPK, HTR2C, DFNA5, SLC39A5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DCDC2_MRS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DCDC2_MRS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCDC2C0036341Schizophrenia1PSYGENET
HgeneDCDC2C1857750DEAFNESS, AUTOSOMAL RECESSIVE 661UNIPROT