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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9407

FusionGeneSummary for DCBLD2_KALRN

check button Fusion gene summary
Fusion gene informationFusion gene name: DCBLD2_KALRN
Fusion gene ID: 9407
HgeneTgene
Gene symbol

DCBLD2

KALRN

Gene ID

131566

8997

Gene namediscoidin, CUB and LCCL domain containing 2kalirin RhoGEF kinase
SynonymsCLCP1|ESDNARHGEF24|CHD5|CHDS5|DUET|DUO|HAPIP|TRAD
Cytomap

3q12.1|3

3q21.1-q21.2

Type of geneprotein-codingprotein-coding
Descriptiondiscoidin, CUB and LCCL domain-containing protein 21700055P21RikCUB, LCCL and coagulation factor V/VIII-homology domains protein 1coagulation factor V/VIII-homology domains protein 1endothelial and smooth muscle cell-derived neuropilin-like proteinkalirinhuntingtin-associated protein interacting protein (duo)serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Modification date2018051920180519
UniProtAcc

Q96PD2

O60229

Ensembl transtripts involved in fusion geneENST00000326840, ENST00000326857, 
ENST00000469648, 		ENST00000477496, 
ENST00000460856, ENST00000240874, 
ENST00000360013, ENST00000393496, 
ENST00000291478, ENST00000428018, 
ENST00000459915, ENST00000462213, 
Fusion gene scores* DoF score4 X 4 X 3=4812 X 9 X 9=972
# samples 414
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/972*10)=-2.79552948666081
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCBLD2 [Title/Abstract] AND KALRN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCBLD2

GO:0030308

negative regulation of cell growth

11447234

HgeneDCBLD2

GO:0042060

wound healing

11447234


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-60-2704-01ADCBLD2chr3

98568305

-KALRNchr3

124193510

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000326840ENST00000477496DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326840ENST00000460856DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326840ENST00000240874DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326840ENST00000360013DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326840ENST00000393496DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326840ENST00000291478DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326840ENST00000428018DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326840ENST00000459915DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326840ENST00000462213DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000477496DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000460856DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000240874DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000360013DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000393496DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000291478DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000428018DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000459915DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5CDS-intronENST00000326857ENST00000462213DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000477496DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000460856DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000240874DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000360013DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000393496DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000291478DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000428018DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000459915DCBLD2chr3

98568305

-KALRNchr3

124193510

+
5UTR-intronENST00000469648ENST00000462213DCBLD2chr3

98568305

-KALRNchr3

124193510

+

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FusionProtFeatures for DCBLD2_KALRN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCBLD2

Q96PD2

KALRN

O60229

Promotes the exchange of GDP by GTP. Activates specificRho GTPase family members, thereby inducing various signalingmechanisms that regulate neuronal shape, growth, and plasticity,through their effects on the actin cytoskeleton. Induceslamellipodia independent of its GEF activity.{ECO:0000269|PubMed:10023074}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCBLD2_KALRN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCBLD2_KALRN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCBLD2SEMA4B, ELAVL1, EGFR, TRAF6, HLA-DRA, ITM2B, PTPRK, SIAE, NAAA, PCDHB11, TCTN2, TMPRSS11BKALRNPAM, RAC1, ATXN7, CACNA1A, CDC5L, DISC1, DTNBP1, NDEL1, LNX1, FASLG, GNB1, COIL, GFI1B, SNCAIP, DICER1, SPTAN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCBLD2_KALRN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCBLD2_KALRN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCBLD2C0032460Polycystic Ovary Syndrome1CTD_human
HgeneDCBLD2C0038356Stomach Neoplasms1CTD_human
TgeneKALRNC0041696Unipolar Depression1PSYGENET
TgeneKALRNC1269683Major Depressive Disorder1PSYGENET