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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9388

FusionGeneSummary for DCAF8_AIG1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF8_AIG1
Fusion gene ID: 9388
HgeneTgene
Gene symbol

DCAF8

AIG1

Gene ID

50717

51390

Gene nameDDB1 and CUL4 associated factor 8androgen induced 1
SynonymsGAN2|H326|WDR42AAIG-1|dJ95L4.1
Cytomap

1q23.2

6q24.2

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 8WD repeat domain 42AWD repeat-containing protein 42Aandrogen-induced gene 1 protein
Modification date2018051920180529
UniProtAcc

Q5TAQ9

Q9NVV5

Ensembl transtripts involved in fusion geneENST00000368073, ENST00000326837, 
ENST00000368074, ENST00000608310, 
ENST00000556710, ENST00000610139, 
ENST00000475733, 		ENST00000357847, 
ENST00000344492, ENST00000275235, 
ENST00000367598, ENST00000494282, 
ENST00000367596, 
Fusion gene scores* DoF score8 X 9 X 5=3606 X 4 X 5=120
# samples 137
** MAII scorelog2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF8 [Title/Abstract] AND AIG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A6L9-06ADCAF8chr1

160252734

-AIG1chr6

143486219

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000368073ENST00000357847DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368073ENST00000344492DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368073ENST00000275235DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368073ENST00000367598DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368073ENST00000494282DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-intronENST00000368073ENST00000367596DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000326837ENST00000357847DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000326837ENST00000344492DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000326837ENST00000275235DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000326837ENST00000367598DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000326837ENST00000494282DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-intronENST00000326837ENST00000367596DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368074ENST00000357847DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368074ENST00000344492DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368074ENST00000275235DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368074ENST00000367598DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000368074ENST00000494282DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-intronENST00000368074ENST00000367596DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000608310ENST00000357847DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000608310ENST00000344492DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000608310ENST00000275235DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000608310ENST00000367598DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000608310ENST00000494282DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-intronENST00000608310ENST00000367596DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000556710ENST00000357847DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000556710ENST00000344492DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000556710ENST00000275235DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000556710ENST00000367598DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-3CDSENST00000556710ENST00000494282DCAF8chr1

160252734

-AIG1chr6

143486219

+
5UTR-intronENST00000556710ENST00000367596DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000610139ENST00000357847DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000610139ENST00000344492DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000610139ENST00000275235DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000610139ENST00000367598DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000610139ENST00000494282DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-intronENST00000610139ENST00000367596DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000475733ENST00000357847DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000475733ENST00000344492DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000475733ENST00000275235DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000475733ENST00000367598DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-3CDSENST00000475733ENST00000494282DCAF8chr1

160252734

-AIG1chr6

143486219

+
intron-intronENST00000475733ENST00000367596DCAF8chr1

160252734

-AIG1chr6

143486219

+

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FusionProtFeatures for DCAF8_AIG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF8

Q5TAQ9

AIG1

Q9NVV5

May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367,ECO:0000269|PubMed:16964240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCAF8_AIG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAF8_AIG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCAF8GTPBP3, MDFI, DDB1, CUL4A, COPS5, KPNA1, KPNB1, XPO1, DDA1, COPS6, COPS2, COPS3, PRMT1, SUV39H1, PRMT8, ACTN1, COPS4, COPS7A, DCAF11, EPB41L2, PRMT5, STAM2, WDR77, TUBGCP3, CUL4B, RAF1, RBPMS, THAP1, MDM2, GGH, FBXW11, PIK3R3, TENC1, MYC, C10orf2, PDE7A, METTL8, AMPD2, FARP1, TFB1M, ARHGEF26, ACAD11, EPB41L5, LOC81691, CCT2, DCAF8L1, TCP1, CCT6B, CCT4, CCT3, ZNF460, C1orf106, TMCO3, GSTK1, CCT5, CCT7, PTPN21, ZNHIT2AIG1RCHY1, GLP1R, VIPR2, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAF8_AIG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAF8_AIG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCAF8C4013360GIANT AXONAL NEUROPATHY 2, AUTOSOMAL DOMINANT1ORPHANET;UNIPROT