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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9387

FusionGeneSummary for DCAF7_VMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF7_VMP1
Fusion gene ID: 9387
HgeneTgene
Gene symbol

DCAF7

VMP1

Gene ID

10238

81671

Gene nameDDB1 and CUL4 associated factor 7vacuole membrane protein 1
SynonymsAN11|HAN11|SWAN-1|WDR68EPG3|TANGO5|TMEM49
Cytomap

17q23.3

17q23.1

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 7WD repeat-containing protein 68WD repeat-containing protein An11 homologhuman anthocyaninseven-WD-repeat protein of the AN11 family-1vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2018052320180523
UniProtAcc

P61962

Q96GC9

Ensembl transtripts involved in fusion geneENST00000577702, ENST00000310827, 
ENST00000431926, ENST00000415273, 
ENST00000262291, ENST00000537567, 
ENST00000539763, ENST00000536180, 
ENST00000545362, ENST00000588617, 
Fusion gene scores* DoF score4 X 4 X 3=4824 X 11 X 12=3168
# samples 627
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/3168*10)=-3.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF7 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A18R-01ADCAF7chr17

61628176

+VMP1chr17

57808782

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000577702ENST00000262291DCAF7chr17

61628176

+VMP1chr17

57808782

+
3UTR-5UTRENST00000577702ENST00000537567DCAF7chr17

61628176

+VMP1chr17

57808782

+
3UTR-5UTRENST00000577702ENST00000539763DCAF7chr17

61628176

+VMP1chr17

57808782

+
3UTR-5UTRENST00000577702ENST00000536180DCAF7chr17

61628176

+VMP1chr17

57808782

+
3UTR-5UTRENST00000577702ENST00000545362DCAF7chr17

61628176

+VMP1chr17

57808782

+
3UTR-intronENST00000577702ENST00000588617DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000310827ENST00000262291DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000310827ENST00000537567DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000310827ENST00000539763DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000310827ENST00000536180DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000310827ENST00000545362DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-intronENST00000310827ENST00000588617DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000431926ENST00000262291DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000431926ENST00000537567DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000431926ENST00000539763DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000431926ENST00000536180DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000431926ENST00000545362DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-intronENST00000431926ENST00000588617DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000415273ENST00000262291DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000415273ENST00000537567DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000415273ENST00000539763DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000415273ENST00000536180DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-5UTRENST00000415273ENST00000545362DCAF7chr17

61628176

+VMP1chr17

57808782

+
5CDS-intronENST00000415273ENST00000588617DCAF7chr17

61628176

+VMP1chr17

57808782

+

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FusionProtFeatures for DCAF7_VMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF7

P61962

VMP1

Q96GC9

Involved in craniofacial development. Acts upstream ofthe EDN1 pathway and is required for formation of the upper jawequivalent, the palatoquadrate. The activity required for EDN1pathway function differs between the first and second arches (Bysimilarity). Associates with DIAPH1 and controls GLI1transcriptional activity. Could be involved in normal and diseaseskin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250,ECO:0000269|PubMed:16887337, ECO:0000269|PubMed:16949367}. Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCAF7_VMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAF7_VMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCAF7MAP3K1, SFN, DYRK1A, DYRK1B, DYRK2, DDB1, FAF2, YWHAG, PARD3, YWHAH, YWHAZ, CUL4A, CUL5, COPS6, HIPK2, DIAPH1, SMAD2, SMAD3, ATP13A2, APP, BARD1, EPAS1, YWHAE, TRAF3, CBX7, BIRC2, BIRC3, LATS2, YWHAB, WWOX, PRKACA, CSNK2A2, PRKACB, AGO2, AURKA, CEP57, CEP76, TP53, VCP, RNF2, CSNK2A1, CCT2, TCP1, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, FBXW11, AUTS2, MED23, B9D2, NINL, XPO1, GTSE1, SKI, TRAF1, RAD54L2, NFATC2, SOWAHC, FBRSL1, SOWAHA, RNF169, TROAP, ZNF703, FAM53C, FBRS, PCGF3, SMARCAL1, ZNF503, YAF2, C10orf71, ERF, FNTB, RYBP, CBX6, NET1, ENAH, GLCCI1, GPBP1L1, CDK17, PPFIBP1, TXNDC5, FOXK1, PRKCI, LRCH3, NUMB, LRCH2, AMBRA1, DOCK7, CRTC3, KIAA1671, CAMSAP3, DDA1, EPS15L1, FAM117B, XRN2, CLASP2, SKP1, DYNLL2, ANKS6, CEP170, PPP1CB, C2orf71, DYNLL1, CBY1, PPP1CA, RAB3IP, INPP5E, BBS12, CCDC40, C21orf2, HSF1, PTPDC1, PLK1, TRIM25, BRCA1, SIRT7VMP1HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAF7_VMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAF7_VMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCAF7C0376634Craniofacial Abnormalities1CTD_human
HgeneDCAF7C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human