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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9384

FusionGeneSummary for DCAF7_DCAF7

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF7_DCAF7
Fusion gene ID: 9384
HgeneTgene
Gene symbol

DCAF7

DCAF7

Gene ID

10238

10238

Gene nameDDB1 and CUL4 associated factor 7DDB1 and CUL4 associated factor 7
SynonymsAN11|HAN11|SWAN-1|WDR68AN11|HAN11|SWAN-1|WDR68
Cytomap

17q23.3

17q23.3

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 7WD repeat-containing protein 68WD repeat-containing protein An11 homologhuman anthocyaninseven-WD-repeat protein of the AN11 family-1DDB1- and CUL4-associated factor 7WD repeat-containing protein 68WD repeat-containing protein An11 homologhuman anthocyaninseven-WD-repeat protein of the AN11 family-1
Modification date2018052320180523
UniProtAcc

P61962

P61962

Ensembl transtripts involved in fusion geneENST00000577702, ENST00000310827, 
ENST00000431926, ENST00000415273, 
ENST00000577702, ENST00000310827, 
ENST00000431926, ENST00000415273, 
Fusion gene scores* DoF score4 X 4 X 3=488 X 6 X 4=192
# samples 610
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF7 [Title/Abstract] AND DCAF7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI031911DCAF7chr17

61662607

+DCAF7chr17

61660904

-
ChiTaRS3.1AL121172DCAF7chr17

61666465

+DCAF7chr17

61662605

-
ChiTaRS3.1DB292839DCAF7chr17

61670830

+DCAF7chr17

61666801

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000577702ENST00000577702DCAF7chr17

61662607

+DCAF7chr17

61660904

-
3UTR-3UTRENST00000577702ENST00000310827DCAF7chr17

61662607

+DCAF7chr17

61660904

-
3UTR-intronENST00000577702ENST00000431926DCAF7chr17

61662607

+DCAF7chr17

61660904

-
3UTR-intronENST00000577702ENST00000415273DCAF7chr17

61662607

+DCAF7chr17

61660904

-
5CDS-3UTRENST00000310827ENST00000577702DCAF7chr17

61662607

+DCAF7chr17

61660904

-
5CDS-3UTRENST00000310827ENST00000310827DCAF7chr17

61662607

+DCAF7chr17

61660904

-
5CDS-intronENST00000310827ENST00000431926DCAF7chr17

61662607

+DCAF7chr17

61660904

-
5CDS-intronENST00000310827ENST00000415273DCAF7chr17

61662607

+DCAF7chr17

61660904

-
intron-3UTRENST00000431926ENST00000577702DCAF7chr17

61662607

+DCAF7chr17

61660904

-
intron-3UTRENST00000431926ENST00000310827DCAF7chr17

61662607

+DCAF7chr17

61660904

-
intron-intronENST00000431926ENST00000431926DCAF7chr17

61662607

+DCAF7chr17

61660904

-
intron-intronENST00000431926ENST00000415273DCAF7chr17

61662607

+DCAF7chr17

61660904

-
5CDS-3UTRENST00000415273ENST00000577702DCAF7chr17

61662607

+DCAF7chr17

61660904

-
5CDS-3UTRENST00000415273ENST00000310827DCAF7chr17

61662607

+DCAF7chr17

61660904

-
5CDS-intronENST00000415273ENST00000431926DCAF7chr17

61662607

+DCAF7chr17

61660904

-
5CDS-intronENST00000415273ENST00000415273DCAF7chr17

61662607

+DCAF7chr17

61660904

-
3UTR-3UTRENST00000577702ENST00000577702DCAF7chr17

61666465

+DCAF7chr17

61662605

-
3UTR-3UTRENST00000577702ENST00000310827DCAF7chr17

61666465

+DCAF7chr17

61662605

-
3UTR-intronENST00000577702ENST00000431926DCAF7chr17

61666465

+DCAF7chr17

61662605

-
3UTR-intronENST00000577702ENST00000415273DCAF7chr17

61666465

+DCAF7chr17

61662605

-
5CDS-3UTRENST00000310827ENST00000577702DCAF7chr17

61666465

+DCAF7chr17

61662605

-
5CDS-3UTRENST00000310827ENST00000310827DCAF7chr17

61666465

+DCAF7chr17

61662605

-
5CDS-intronENST00000310827ENST00000431926DCAF7chr17

61666465

+DCAF7chr17

61662605

-
5CDS-intronENST00000310827ENST00000415273DCAF7chr17

61666465

+DCAF7chr17

61662605

-
intron-3UTRENST00000431926ENST00000577702DCAF7chr17

61666465

+DCAF7chr17

61662605

-
intron-3UTRENST00000431926ENST00000310827DCAF7chr17

61666465

+DCAF7chr17

61662605

-
intron-intronENST00000431926ENST00000431926DCAF7chr17

61666465

+DCAF7chr17

61662605

-
intron-intronENST00000431926ENST00000415273DCAF7chr17

61666465

+DCAF7chr17

61662605

-
5CDS-3UTRENST00000415273ENST00000577702DCAF7chr17

61666465

+DCAF7chr17

61662605

-
5CDS-3UTRENST00000415273ENST00000310827DCAF7chr17

61666465

+DCAF7chr17

61662605

-
5CDS-intronENST00000415273ENST00000431926DCAF7chr17

61666465

+DCAF7chr17

61662605

-
5CDS-intronENST00000415273ENST00000415273DCAF7chr17

61666465

+DCAF7chr17

61662605

-
3UTR-3UTRENST00000577702ENST00000577702DCAF7chr17

61670830

+DCAF7chr17

61666801

+
3UTR-3UTRENST00000577702ENST00000310827DCAF7chr17

61670830

+DCAF7chr17

61666801

+
3UTR-intronENST00000577702ENST00000431926DCAF7chr17

61670830

+DCAF7chr17

61666801

+
3UTR-3UTRENST00000577702ENST00000415273DCAF7chr17

61670830

+DCAF7chr17

61666801

+
3UTR-3UTRENST00000310827ENST00000577702DCAF7chr17

61670830

+DCAF7chr17

61666801

+
3UTR-3UTRENST00000310827ENST00000310827DCAF7chr17

61670830

+DCAF7chr17

61666801

+
3UTR-intronENST00000310827ENST00000431926DCAF7chr17

61670830

+DCAF7chr17

61666801

+
3UTR-3UTRENST00000310827ENST00000415273DCAF7chr17

61670830

+DCAF7chr17

61666801

+
intron-3UTRENST00000431926ENST00000577702DCAF7chr17

61670830

+DCAF7chr17

61666801

+
intron-3UTRENST00000431926ENST00000310827DCAF7chr17

61670830

+DCAF7chr17

61666801

+
intron-intronENST00000431926ENST00000431926DCAF7chr17

61670830

+DCAF7chr17

61666801

+
intron-3UTRENST00000431926ENST00000415273DCAF7chr17

61670830

+DCAF7chr17

61666801

+
intron-3UTRENST00000415273ENST00000577702DCAF7chr17

61670830

+DCAF7chr17

61666801

+
intron-3UTRENST00000415273ENST00000310827DCAF7chr17

61670830

+DCAF7chr17

61666801

+
intron-intronENST00000415273ENST00000431926DCAF7chr17

61670830

+DCAF7chr17

61666801

+
intron-3UTRENST00000415273ENST00000415273DCAF7chr17

61670830

+DCAF7chr17

61666801

+

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FusionProtFeatures for DCAF7_DCAF7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF7

P61962

DCAF7

P61962

Involved in craniofacial development. Acts upstream ofthe EDN1 pathway and is required for formation of the upper jawequivalent, the palatoquadrate. The activity required for EDN1pathway function differs between the first and second arches (Bysimilarity). Associates with DIAPH1 and controls GLI1transcriptional activity. Could be involved in normal and diseaseskin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250,ECO:0000269|PubMed:16887337, ECO:0000269|PubMed:16949367}. Involved in craniofacial development. Acts upstream ofthe EDN1 pathway and is required for formation of the upper jawequivalent, the palatoquadrate. The activity required for EDN1pathway function differs between the first and second arches (Bysimilarity). Associates with DIAPH1 and controls GLI1transcriptional activity. Could be involved in normal and diseaseskin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250,ECO:0000269|PubMed:16887337, ECO:0000269|PubMed:16949367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCAF7_DCAF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAF7_DCAF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAF7_DCAF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAF7_DCAF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCAF7C0376634Craniofacial Abnormalities1CTD_human
HgeneDCAF7C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
TgeneDCAF7C0376634Craniofacial Abnormalities1CTD_human
TgeneDCAF7C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human