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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9373

FusionGeneSummary for DCAF6_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF6_BCAS3
Fusion gene ID: 9373
HgeneTgene
Gene symbol

DCAF6

BCAS3

Gene ID

55827

54828

Gene nameDDB1 and CUL4 associated factor 6BCAS3, microtubule associated cell migration factor
Synonyms1200006M05Rik|ARCAP|IQWD1|MSTP055|NRIP|PC326GAOB1|MAAB
Cytomap

1q24.2

17q23.2

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 6IQ motif and WD repeat-containing protein 1IQ motif and WD repeats 1androgen receptor complex-associated proteinnuclear receptor interaction proteinbreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018051920180523
UniProtAcc

Q58WW2

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000367843, ENST00000432587, 
ENST00000312263, ENST00000367840, 
ENST00000470919, 
ENST00000589222, 
ENST00000407086, ENST00000390652, 
ENST00000408905, ENST00000588462, 
ENST00000585744, ENST00000588874, 
ENST00000585812, 
Fusion gene scores* DoF score11 X 6 X 6=39626 X 15 X 15=5850
# samples 1241
** MAII scorelog2(12/396*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF6 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-AAMX-01ADCAF6chr1

167974031

+BCAS3chr17

58987893

+
TCGALDBLCATCGA-XF-AAMX-01ADCAF6chr1

167992285

+BCAS3chr17

58987893

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000367843ENST00000589222DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000407086DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000390652DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000408905DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000588462DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000585744DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000588874DCAF6chr1

167974031

+BCAS3chr17

58987893

+
5CDS-intronENST00000367843ENST00000585812DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000589222DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000407086DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000390652DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000408905DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000588462DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000585744DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000588874DCAF6chr1

167974031

+BCAS3chr17

58987893

+
5CDS-intronENST00000432587ENST00000585812DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000312263ENST00000589222DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000312263ENST00000407086DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000312263ENST00000390652DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000312263ENST00000408905DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000312263ENST00000588462DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000312263ENST00000585744DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000312263ENST00000588874DCAF6chr1

167974031

+BCAS3chr17

58987893

+
5CDS-intronENST00000312263ENST00000585812DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000589222DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000407086DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000390652DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000408905DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000588462DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000585744DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000588874DCAF6chr1

167974031

+BCAS3chr17

58987893

+
5CDS-intronENST00000367840ENST00000585812DCAF6chr1

167974031

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000589222DCAF6chr1

167974031

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000407086DCAF6chr1

167974031

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000390652DCAF6chr1

167974031

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000408905DCAF6chr1

167974031

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000588462DCAF6chr1

167974031

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000585744DCAF6chr1

167974031

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000588874DCAF6chr1

167974031

+BCAS3chr17

58987893

+
intron-intronENST00000470919ENST00000585812DCAF6chr1

167974031

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000589222DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000407086DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000390652DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000408905DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000588462DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000585744DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367843ENST00000588874DCAF6chr1

167992285

+BCAS3chr17

58987893

+
5CDS-intronENST00000367843ENST00000585812DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000589222DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000407086DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000390652DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000408905DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000588462DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000585744DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000432587ENST00000588874DCAF6chr1

167992285

+BCAS3chr17

58987893

+
5CDS-intronENST00000432587ENST00000585812DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000312263ENST00000589222DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000312263ENST00000407086DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000312263ENST00000390652DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000312263ENST00000408905DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000312263ENST00000588462DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000312263ENST00000585744DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000312263ENST00000588874DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-intronENST00000312263ENST00000585812DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000589222DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000407086DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000390652DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000408905DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000588462DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000585744DCAF6chr1

167992285

+BCAS3chr17

58987893

+
Frame-shitENST00000367840ENST00000588874DCAF6chr1

167992285

+BCAS3chr17

58987893

+
5CDS-intronENST00000367840ENST00000585812DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000589222DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000407086DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000390652DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000408905DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000588462DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000585744DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-3CDSENST00000470919ENST00000588874DCAF6chr1

167992285

+BCAS3chr17

58987893

+
intron-intronENST00000470919ENST00000585812DCAF6chr1

167992285

+BCAS3chr17

58987893

+

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FusionProtFeatures for DCAF6_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF6

Q58WW2

BCAS3

Q9H6U6

Ligand-dependent coactivator of nuclear receptors.Enhance transcriptional activity of the nuclear receptors NR3C1and AR. May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617,ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCAF6_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAF6_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCAF6DDB1, CUL4A, SP1, AR, DCAF6, NR3C1, DDA1, CBX2, CBX4, ACACA, KPNA1, USP9X, TRIM63, TRIM55, CUL4B, MOV10, NXF1, C1QTNF2, PIH1D1, MAGEA1, MAGEA4, NFKBIA, NR2E1, BMP15, COPS2, VPS28, DNAJB1, WDFY3, FAM46A, CALN1, YAF2, C10orf88, TRIM25, GTF2IRD1BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAF6_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAF6_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCAF6C0033578Prostatic Neoplasms1CTD_human