	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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	RelatedDiseases

Fusion gene ID: 9373

FusionGeneSummary for DCAF6_BCAS3

Fusion gene summary

Fusion gene information	Fusion gene name: DCAF6_BCAS3
	Fusion gene ID: 9373
		Hgene	Tgene
	Gene symbol	DCAF6	BCAS3
	Gene ID	55827	54828
	Gene name	DDB1 and CUL4 associated factor 6	BCAS3, microtubule associated cell migration factor
	Synonyms	1200006M05Rik\|ARCAP\|IQWD1\|MSTP055\|NRIP\|PC326	GAOB1\|MAAB
	Cytomap	1q24.2	17q23.2
	Type of gene	protein-coding	protein-coding
	Description	DDB1- and CUL4-associated factor 6IQ motif and WD repeat-containing protein 1IQ motif and WD repeats 1androgen receptor complex-associated proteinnuclear receptor interaction protein	breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
	Modification date	20180519	20180523
	UniProtAcc	Q58WW2	Q9H6U6
	Ensembl transtripts involved in fusion gene	ENST00000367843, ENST00000432587, ENST00000312263, ENST00000367840, ENST00000470919,	ENST00000589222, ENST00000407086, ENST00000390652, ENST00000408905, ENST00000588462, ENST00000585744, ENST00000588874, ENST00000585812,
Fusion gene scores	* DoF score	11 X 6 X 6=396	26 X 15 X 15=5850
	# samples	12	41
	** MAII score	log2(12/396*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(41/5850*10)=-3.83474080985268 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DCAF6 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BCAS3	GO:0043085	positive regulation of catalytic activity	17505058
Tgene	BCAS3	GO:0045944	positive regulation of transcription by RNA polymerase II	17505058
Tgene	BCAS3	GO:0071391	cellular response to estrogen stimulus	17505058

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-XF-AAMX-01A	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
TCGA	LD	BLCA	TCGA-XF-AAMX-01A	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000367843	ENST00000589222	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000407086	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000390652	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000408905	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000588462	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000585744	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000588874	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
5CDS-intron	ENST00000367843	ENST00000585812	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000589222	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000407086	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000390652	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000408905	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000588462	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000585744	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000588874	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
5CDS-intron	ENST00000432587	ENST00000585812	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000312263	ENST00000589222	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000312263	ENST00000407086	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000312263	ENST00000390652	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000312263	ENST00000408905	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000312263	ENST00000588462	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000312263	ENST00000585744	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000312263	ENST00000588874	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
5CDS-intron	ENST00000312263	ENST00000585812	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000589222	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000407086	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000390652	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000408905	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000588462	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000585744	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000588874	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
5CDS-intron	ENST00000367840	ENST00000585812	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000589222	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000407086	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000390652	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000408905	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000588462	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000585744	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000588874	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
intron-intron	ENST00000470919	ENST00000585812	DCAF6	chr1	167974031	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000589222	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000407086	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000390652	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000408905	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000588462	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000585744	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367843	ENST00000588874	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
5CDS-intron	ENST00000367843	ENST00000585812	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000589222	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000407086	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000390652	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000408905	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000588462	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000585744	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000432587	ENST00000588874	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
5CDS-intron	ENST00000432587	ENST00000585812	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000312263	ENST00000589222	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000312263	ENST00000407086	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000312263	ENST00000390652	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000312263	ENST00000408905	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000312263	ENST00000588462	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000312263	ENST00000585744	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000312263	ENST00000588874	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-intron	ENST00000312263	ENST00000585812	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000589222	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000407086	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000390652	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000408905	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000588462	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000585744	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
Frame-shift	ENST00000367840	ENST00000588874	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
5CDS-intron	ENST00000367840	ENST00000585812	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000589222	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000407086	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000390652	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000408905	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000588462	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000585744	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-3CDS	ENST00000470919	ENST00000588874	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+
intron-intron	ENST00000470919	ENST00000585812	DCAF6	chr1	167992285	+	BCAS3	chr17	58987893	+

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FusionProtFeatures for DCAF6_BCAS3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DCAF6 Q58WW2	BCAS3 Q9H6U6
Ligand-dependent coactivator of nuclear receptors.Enhance transcriptional activity of the nuclear receptors NR3C1and AR. May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269\|PubMed:15784617,ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for DCAF6_BCAS3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAF6_BCAS3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
DCAF6	DDB1, CUL4A, SP1, AR, DCAF6, NR3C1, DDA1, CBX2, CBX4, ACACA, KPNA1, USP9X, TRIM63, TRIM55, CUL4B, MOV10, NXF1, C1QTNF2, PIH1D1, MAGEA1, MAGEA4, NFKBIA, NR2E1, BMP15, COPS2, VPS28, DNAJB1, WDFY3, FAM46A, CALN1, YAF2, C10orf88, TRIM25, GTF2IRD1	BCAS3	CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for DCAF6_BCAS3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DCAF6_BCAS3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DCAF6	C0033578	Prostatic Neoplasms	1	CTD_human

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Fusion gene ID: 9373

FusionGeneSummary for DCAF6_BCAS3

FusionProtFeatures for DCAF6_BCAS3

FusionGeneSequence for DCAF6_BCAS3

FusionGenePPI for DCAF6_BCAS3

RelatedDrugs for DCAF6_BCAS3

RelatedDiseases for DCAF6_BCAS3