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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9368

FusionGeneSummary for DCAF5_NOXRED1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF5_NOXRED1
Fusion gene ID: 9368
HgeneTgene
Gene symbol

DCAF5

NOXRED1

Gene ID

8816

122945

Gene nameDDB1 and CUL4 associated factor 5NADP dependent oxidoreductase domain containing 1
SynonymsBCRG2|BCRP2|D14S1461E|WDR22C14orf148
Cytomap

14q24.1

14q24.3

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2NADP-dependent oxidoreductase domain-containing protein 1pyrroline-5-carboxylate reductase-like protein C14orf148
Modification date2018051920180519
UniProtAcc

Q96JK2

Q6NXP6

Ensembl transtripts involved in fusion geneENST00000341516, ENST00000554215, 
ENST00000556847, ENST00000557386, 
ENST00000389997, ENST00000553293, 
ENST00000380835, ENST00000298358, 
Fusion gene scores* DoF score12 X 8 X 7=6721 X 1 X 1=1
# samples 131
** MAII scorelog2(13/672*10)=-2.36994960975031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DCAF5 [Title/Abstract] AND NOXRED1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-2092-01ADCAF5chr14

69529101

-NOXRED1chr14

77861148

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000341516ENST00000380835DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
5CDS-intronENST00000341516ENST00000298358DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
Frame-shiftENST00000554215ENST00000380835DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
5CDS-intronENST00000554215ENST00000298358DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
Frame-shiftENST00000556847ENST00000380835DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
5CDS-intronENST00000556847ENST00000298358DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
Frame-shiftENST00000557386ENST00000380835DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
5CDS-intronENST00000557386ENST00000298358DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
intron-3CDSENST00000389997ENST00000380835DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
intron-intronENST00000389997ENST00000298358DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
intron-3CDSENST00000553293ENST00000380835DCAF5chr14

69529101

-NOXRED1chr14

77861148

-
intron-intronENST00000553293ENST00000298358DCAF5chr14

69529101

-NOXRED1chr14

77861148

-

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FusionProtFeatures for DCAF5_NOXRED1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF5

Q96JK2

NOXRED1

Q6NXP6

May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367,ECO:0000269|PubMed:16964240}. Probable oxidoreductase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCAF5_NOXRED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAF5_NOXRED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCAF5DDB1, CUL4A, DDA1, UBC, GRK5, CCDC84, TCP1, CCT7, PFDN4, CCT6B, CCT6A, CCT2, CCT3, PFDN5, HSPD1, PDRG1, PFDN6, VBP1, RWDD2B, SFRP4, LHX4, TSGA10IP, MRPS11, PIP5K1A, DYRK2, EPB41L5, TCF25, SOST, WIBG, ZNF816, NUAK2, ARRB1, PFDN1, GPBP1L1, TYW3, RPS14, CCT5, SPATA24, PTPN21, TRIM25, SIRT7NOXRED1MPZL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAF5_NOXRED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAF5_NOXRED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource