FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 9362

FusionGeneSummary for DCAF5_C14orf39

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF5_C14orf39
Fusion gene ID: 9362
HgeneTgene
Gene symbol

DCAF5

C14orf39

Gene ID

8816

317761

Gene nameDDB1 and CUL4 associated factor 5chromosome 14 open reading frame 39
SynonymsBCRG2|BCRP2|D14S1461E|WDR22Six6os1
Cytomap

14q24.1

14q23.1

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2protein SIX6OS1six6 opposite strand transcript 1
Modification date2018051920180331
UniProtAcc

Q96JK2

Ensembl transtripts involved in fusion geneENST00000341516, ENST00000554215, 
ENST00000556847, ENST00000557386, 
ENST00000389997, ENST00000553293, 
ENST00000321731, 
Fusion gene scores* DoF score12 X 8 X 7=6723 X 4 X 3=36
# samples 133
** MAII scorelog2(13/672*10)=-2.36994960975031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF5 [Title/Abstract] AND C14orf39 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7143-01ADCAF5chr14

69558391

-C14orf39chr14

60938457

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000341516ENST00000321731DCAF5chr14

69558391

-C14orf39chr14

60938457

-
Frame-shitENST00000554215ENST00000321731DCAF5chr14

69558391

-C14orf39chr14

60938457

-
Frame-shitENST00000556847ENST00000321731DCAF5chr14

69558391

-C14orf39chr14

60938457

-
Frame-shitENST00000557386ENST00000321731DCAF5chr14

69558391

-C14orf39chr14

60938457

-
Frame-shitENST00000389997ENST00000321731DCAF5chr14

69558391

-C14orf39chr14

60938457

-
5UTR-3CDSENST00000553293ENST00000321731DCAF5chr14

69558391

-C14orf39chr14

60938457

-

Top

FusionProtFeatures for DCAF5_C14orf39


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF5

Q96JK2

C14orf39

May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367,ECO:0000269|PubMed:16964240}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DCAF5_C14orf39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DCAF5_C14orf39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCAF5DDB1, CUL4A, DDA1, UBC, GRK5, CCDC84, TCP1, CCT7, PFDN4, CCT6B, CCT6A, CCT2, CCT3, PFDN5, HSPD1, PDRG1, PFDN6, VBP1, RWDD2B, SFRP4, LHX4, TSGA10IP, MRPS11, PIP5K1A, DYRK2, EPB41L5, TCF25, SOST, WIBG, ZNF816, NUAK2, ARRB1, PFDN1, GPBP1L1, TYW3, RPS14, CCT5, SPATA24, PTPN21, TRIM25, SIRT7C14orf39


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DCAF5_C14orf39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DCAF5_C14orf39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource