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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9349

FusionGeneSummary for DCAF10_PAX5

check button Fusion gene summary
Fusion gene informationFusion gene name: DCAF10_PAX5
Fusion gene ID: 9349
HgeneTgene
Gene symbol

DCAF10

PAX5

Gene ID

79269

5079

Gene nameDDB1 and CUL4 associated factor 10paired box 5
SynonymsWDR32ALL3|BSAP
Cytomap

9p13.2

9p13.2

Type of geneprotein-codingprotein-coding
DescriptionDDB1- and CUL4-associated factor 10WD repeat domain 32WD repeat-containing protein 32paired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5
Modification date2018051920180520
UniProtAcc

Q5QP82

Q02548

Ensembl transtripts involved in fusion geneENST00000377724, ENST00000242323, 
ENST00000483167, 
ENST00000358127, 
ENST00000523241, ENST00000520154, 
ENST00000377852, ENST00000377853, 
ENST00000522003, ENST00000520281, 
ENST00000414447, ENST00000523145, 
ENST00000446742, ENST00000377847, 
Fusion gene scores* DoF score2 X 3 X 2=127 X 5 X 5=175
# samples 37
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCAF10 [Title/Abstract] AND PAX5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-77-8009-01ADCAF10chr9

37801402

+PAX5chr9

37020798

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000377724ENST00000358127DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000377724ENST00000523241DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000377724ENST00000520154DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000377724ENST00000377852DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000377724ENST00000377853DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000377724ENST00000522003DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000377724ENST00000520281DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000377724ENST00000414447DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000377724ENST00000523145DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000377724ENST00000446742DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000377724ENST00000377847DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000242323ENST00000358127DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000242323ENST00000523241DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000242323ENST00000520154DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000242323ENST00000377852DCAF10chr9

37801402

+PAX5chr9

37020798

-
Frame-shitENST00000242323ENST00000377853DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000242323ENST00000522003DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000242323ENST00000520281DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000242323ENST00000414447DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000242323ENST00000523145DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000242323ENST00000446742DCAF10chr9

37801402

+PAX5chr9

37020798

-
5CDS-intronENST00000242323ENST00000377847DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-3CDSENST00000483167ENST00000358127DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-3CDSENST00000483167ENST00000523241DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-3CDSENST00000483167ENST00000520154DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-3CDSENST00000483167ENST00000377852DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-3CDSENST00000483167ENST00000377853DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-intronENST00000483167ENST00000522003DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-intronENST00000483167ENST00000520281DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-intronENST00000483167ENST00000414447DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-intronENST00000483167ENST00000523145DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-intronENST00000483167ENST00000446742DCAF10chr9

37801402

+PAX5chr9

37020798

-
intron-intronENST00000483167ENST00000377847DCAF10chr9

37801402

+PAX5chr9

37020798

-

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FusionProtFeatures for DCAF10_PAX5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCAF10

Q5QP82

PAX5

Q02548

May function as a substrate receptor for CUL4-DDB1 E3ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DCAF10_PAX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DCAF10_PAX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DCAF10SLX4, DDB1, CUL4A, DDA1, COPS6, AGO1, DIRAS3, SNX11, HDAC7, ACTR8, EIF3I, TRUB2, GNAZ, SCRN2, PPP2R2C, SRPK2, CUL4B, JRKL, COPS7A, CCT6B, CCT3, MTUS2, CCT2, CCT4, PRIM1, TCP1, CIR1, STK16, CCT7, PRIM2, NECAB2, RGS20, NKIRAS2, PTPN7, TRIM25PAX5TLE4, DAXX, RUNX1, MYB, ID3, EP300, TBP, RB1, MAPK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DCAF10_PAX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DCAF10_PAX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePAX5C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CTD_human;UNIPROT
TgenePAX5C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human