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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9344

FusionGeneSummary for DBNL_EEA1

check button Fusion gene summary
Fusion gene informationFusion gene name: DBNL_EEA1
Fusion gene ID: 9344
HgeneTgene
Gene symbol

DBNL

EEA1

Gene ID

28988

8411

Gene namedrebrin likeearly endosome antigen 1
SynonymsABP1|HIP-55|HIP55|SH3P7MST105|MSTP105|ZFYVE2
Cytomap

7p13

12q22

Type of geneprotein-codingprotein-coding
Descriptiondrebrin-like proteinHPK1-interacting protein of 55 kDaSH3 domain-containing protein 7actin-binding protein 1cervical SH3P7cervical mucin-associated proteindrebrin-Fsrc homology 3 domain-containing protein HIP-55early endosome antigen 1early endosome antigen 1, 162kDearly endosome-associated proteinendosome-associated protein p162zinc finger FYVE domain-containing protein 2
Modification date2018052220180522
UniProtAcc

Q9UJU6

Q15075

Ensembl transtripts involved in fusion geneENST00000448521, ENST00000456905, 
ENST00000440166, ENST00000452943, 
ENST00000468694, ENST00000494774, 
ENST00000490734, ENST00000497184, 
ENST00000322349, ENST00000547833, 
Fusion gene scores* DoF score2 X 2 X 2=822 X 3 X 11=726
# samples 220
** MAII scorelog2(2/8*10)=1.32192809488736log2(20/726*10)=-1.85996954822103
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DBNL [Title/Abstract] AND EEA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CR-7382-01ADBNLchr7

44101257

+EEA1chr12

93229203

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000448521ENST00000322349DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000448521ENST00000547833DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000456905ENST00000322349DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000456905ENST00000547833DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000440166ENST00000322349DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000440166ENST00000547833DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000452943ENST00000322349DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000452943ENST00000547833DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000468694ENST00000322349DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000468694ENST00000547833DBNLchr7

44101257

+EEA1chr12

93229203

-
3UTR-intronENST00000494774ENST00000322349DBNLchr7

44101257

+EEA1chr12

93229203

-
3UTR-intronENST00000494774ENST00000547833DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000490734ENST00000322349DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000490734ENST00000547833DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000497184ENST00000322349DBNLchr7

44101257

+EEA1chr12

93229203

-
intron-intronENST00000497184ENST00000547833DBNLchr7

44101257

+EEA1chr12

93229203

-

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FusionProtFeatures for DBNL_EEA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DBNL

Q9UJU6

EEA1

Q15075

Binds phospholipid vesicles containingphosphatidylinositol 3-phosphate and participates in endosomaltrafficking.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DBNL_EEA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DBNL_EEA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DBNLSH2D4A, HERC2, GPS2, DNPEP, CDK4, EIF2AK2, RB1CC1, CYP4F8, ZAP70, MAP4K1, CASP3, KDM5B, SH3BP2, CBL, TERF1, TERF2IP, ACD, POT1, CUL1, BAG3, AGFG1, ALAD, C14orf142, CBS, LPP, DDX5, DR1, ERO1L, GPN1, HSPBP1, P3H1, LRSAM1, OGT, PLIN3, PPME1, RANGAP1, TPRKB, UBA5, UBE3A, WDR4, RBM23, FGD6, ECI2, CMAS, USP20, NEURL4, CFL1, NTRK1, CDH1, DUSP8, GTF2E2, HOMER1, TESEEA1RAB22A, RAB5A, EEA1, STX12, NSF, RABEP1, RAB5C, IGF1R, PXK, PDCD6IP, RABGEF1, TNK2, VCP, ERBB2, CFTR, CCDC8, RNF2, BMI1, FCGR2A, PPP1R3C, MARS, PCNA, TP53, RRAD, NUPL1, MLLT6, SERPINB2, FUOM, BMP1, SNRNP27, TMA16, USP47, RAB31, PTPRQ, PIBF1, SNX27


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DBNL_EEA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DBNL_EEA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDBNLC0005586Bipolar Disorder1PSYGENET