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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9341

FusionGeneSummary for DBNDD1_NAA60

check button Fusion gene summary
Fusion gene informationFusion gene name: DBNDD1_NAA60
Fusion gene ID: 9341
HgeneTgene
Gene symbol

DBNDD1

NAA60

Gene ID

79007

79903

Gene namedysbindin domain containing 1N(alpha)-acetyltransferase 60, NatF catalytic subunit
Synonyms-HAT4|NAT15|NatF|hNaa60
Cytomap

16q24.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptiondysbindin domain-containing protein 1dysbindin (dystrobrevin binding protein 1) domain containing 1N-alpha-acetyltransferase 60N-acetyltransferase 15 (GCN5-related, putative)N-alpha-acetyltransferase Fhistone acetyltransferase type B protein 4
Modification date2018032920180523
UniProtAcc

Q9H9R9

Q9H7X0

Ensembl transtripts involved in fusion geneENST00000304733, ENST00000002501, 
ENST00000392973, ENST00000568838, 
ENST00000576906, ENST00000407558, 
ENST00000608722, ENST00000424546, 
ENST00000573580, ENST00000421765, 
ENST00000610180, ENST00000608993, 
ENST00000360862, ENST00000414063, 
ENST00000570551, ENST00000572942, 
ENST00000576916, ENST00000575076, 
ENST00000577013, ENST00000570819, 
ENST00000572584, 
Fusion gene scores* DoF score3 X 2 X 2=122 X 2 X 2=8
# samples 32
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: DBNDD1 [Title/Abstract] AND NAA60 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNAA60

GO:0006334

nucleosome assembly

21981917

TgeneNAA60

GO:0006474

N-terminal protein amino acid acetylation

25732826|27320834|27550639

TgeneNAA60

GO:0017196

N-terminal peptidyl-methionine acetylation

21750686

TgeneNAA60

GO:0043967

histone H4 acetylation

21981917


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF733969DBNDD1chr16

90072158

-NAA60chr16

3533508

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000304733ENST00000576906DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000407558DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000608722DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000424546DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000573580DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000421765DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000610180DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000608993DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000360862DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000414063DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-3UTRENST00000304733ENST00000570551DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000572942DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000576916DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000575076DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000577013DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000570819DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000304733ENST00000572584DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000576906DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000407558DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000608722DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000424546DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000573580DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000421765DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000610180DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000608993DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000360862DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000414063DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-3UTRENST00000002501ENST00000570551DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000572942DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000576916DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000575076DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000577013DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000570819DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000002501ENST00000572584DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000576906DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000407558DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000608722DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000424546DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000573580DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000421765DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000610180DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000608993DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000360862DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000414063DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-3UTRENST00000392973ENST00000570551DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000572942DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000576916DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000575076DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000577013DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000570819DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000392973ENST00000572584DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000576906DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000407558DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000608722DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000424546DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000573580DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000421765DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000610180DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000608993DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000360862DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000414063DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-3UTRENST00000568838ENST00000570551DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000572942DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000576916DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000575076DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000577013DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000570819DBNDD1chr16

90072158

-NAA60chr16

3533508

+
intron-intronENST00000568838ENST00000572584DBNDD1chr16

90072158

-NAA60chr16

3533508

+

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FusionProtFeatures for DBNDD1_NAA60


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DBNDD1

Q9H9R9

NAA60

Q9H7X0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DBNDD1_NAA60


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DBNDD1_NAA60


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DBNDD1_NAA60


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DBNDD1_NAA60


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource