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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9320

FusionGeneSummary for DAZAP1_IDH3G

check button Fusion gene summary
Fusion gene informationFusion gene name: DAZAP1_IDH3G
Fusion gene ID: 9320
HgeneTgene
Gene symbol

DAZAP1

IDH3G

Gene ID

26528

3421

Gene nameDAZ associated protein 1isocitrate dehydrogenase 3 (NAD(+)) gamma
Synonyms-H-IDHG
Cytomap

19p13.3

Xq28

Type of geneprotein-codingprotein-coding
DescriptionDAZ-associated protein 1deleted in azoospermia-associated protein 1testicular tissue protein Li 50isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialIDH-gammaNAD (H)-specific isocitrate dehydrogenase gamma subunitNAD(+)-specific ICDH subunit gammaNAD+-specific ICDHisocitrate dehydrogenase 3 (NAD+) gammaisocitrate dehydrogenase 3 gammais
Modification date2018052320180522
UniProtAcc

Q96EP5

P51553

Ensembl transtripts involved in fusion geneENST00000336761, ENST00000233078, 
ENST00000586579, 
ENST00000370092, 
ENST00000217901, ENST00000370093, 
ENST00000427365, ENST00000497043, 
Fusion gene scores* DoF score8 X 6 X 4=1921 X 1 X 1=1
# samples 91
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DAZAP1 [Title/Abstract] AND IDH3G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF902554DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000336761ENST00000370092DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000336761ENST00000217901DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000336761ENST00000370093DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000336761ENST00000427365DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-5UTRENST00000336761ENST00000497043DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000233078ENST00000370092DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000233078ENST00000217901DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000233078ENST00000370093DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000233078ENST00000427365DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-5UTRENST00000233078ENST00000497043DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000586579ENST00000370092DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000586579ENST00000217901DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000586579ENST00000370093DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-3CDSENST00000586579ENST00000427365DAZAP1chr19

1420000

+IDH3GchrX

153052996

+
intron-5UTRENST00000586579ENST00000497043DAZAP1chr19

1420000

+IDH3GchrX

153052996

+

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FusionProtFeatures for DAZAP1_IDH3G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAZAP1

Q96EP5

IDH3G

P51553

RNA-binding protein, which may be required duringspermatogenesis. Regulatory subunit which plays a role in the allostericregulation of the enzyme catalyzing the decarboxylation ofisocitrate (ICT) into alpha-ketoglutarate. The heterodimercomposed of the alpha (IDH3A) and beta (IDH3B) subunits and theheterodimer composed of the alpha (IDH3A) and gamma (IDH3G)subunits, have considerable basal activity but the full activityof the heterotetramer (containing two subunits of IDH3A, one ofIDH3B and one of IDH3G) requires the assembly and cooperativefunction of both heterodimers. {ECO:0000269|PubMed:28139779}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAZAP1_IDH3G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAZAP1_IDH3G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAZAP1_IDH3G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DAZAP1_IDH3G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDAZAP1C0005586Bipolar Disorder1PSYGENET
HgeneDAZAP1C0036341Schizophrenia1PSYGENET