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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9303

FusionGeneSummary for DAP_CTNND2

check button Fusion gene summary
Fusion gene informationFusion gene name: DAP_CTNND2
Fusion gene ID: 9303
HgeneTgene
Gene symbol

DAP

CTNND2

Gene ID

23549

1501

Gene nameaspartyl aminopeptidasecatenin delta 2
SynonymsASPEP|DAPGT24|NPRAP
Cytomap

2q35

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionaspartyl aminopeptidasecatenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojungin
Modification date2018052320180523
UniProtAcc

P51397

Q9UQB3

Ensembl transtripts involved in fusion geneENST00000230895, ENST00000432074, 
ENST00000510546, 
ENST00000304623, 
ENST00000359640, ENST00000511377, 
ENST00000458100, ENST00000503622, 
ENST00000495388, 
Fusion gene scores* DoF score9 X 5 X 7=31512 X 8 X 8=768
# samples 1012
** MAII scorelog2(10/315*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/768*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAP [Title/Abstract] AND CTNND2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-AAVV-01ADAPchr5

10748287

-CTNND2chr5

11732384

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000230895ENST00000304623DAPchr5

10748287

-CTNND2chr5

11732384

-
Frame-shiftENST00000230895ENST00000359640DAPchr5

10748287

-CTNND2chr5

11732384

-
5CDS-intronENST00000230895ENST00000511377DAPchr5

10748287

-CTNND2chr5

11732384

-
5CDS-5UTRENST00000230895ENST00000458100DAPchr5

10748287

-CTNND2chr5

11732384

-
5CDS-intronENST00000230895ENST00000503622DAPchr5

10748287

-CTNND2chr5

11732384

-
5CDS-intronENST00000230895ENST00000495388DAPchr5

10748287

-CTNND2chr5

11732384

-
Frame-shiftENST00000432074ENST00000304623DAPchr5

10748287

-CTNND2chr5

11732384

-
Frame-shiftENST00000432074ENST00000359640DAPchr5

10748287

-CTNND2chr5

11732384

-
5CDS-intronENST00000432074ENST00000511377DAPchr5

10748287

-CTNND2chr5

11732384

-
5CDS-5UTRENST00000432074ENST00000458100DAPchr5

10748287

-CTNND2chr5

11732384

-
5CDS-intronENST00000432074ENST00000503622DAPchr5

10748287

-CTNND2chr5

11732384

-
5CDS-intronENST00000432074ENST00000495388DAPchr5

10748287

-CTNND2chr5

11732384

-
5UTR-3CDSENST00000510546ENST00000304623DAPchr5

10748287

-CTNND2chr5

11732384

-
5UTR-3CDSENST00000510546ENST00000359640DAPchr5

10748287

-CTNND2chr5

11732384

-
5UTR-intronENST00000510546ENST00000511377DAPchr5

10748287

-CTNND2chr5

11732384

-
5UTR-5UTRENST00000510546ENST00000458100DAPchr5

10748287

-CTNND2chr5

11732384

-
5UTR-intronENST00000510546ENST00000503622DAPchr5

10748287

-CTNND2chr5

11732384

-
5UTR-intronENST00000510546ENST00000495388DAPchr5

10748287

-CTNND2chr5

11732384

-

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FusionProtFeatures for DAP_CTNND2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAP

P51397

CTNND2

Q9UQB3

Negative regulator of autophagy. Involved in mediatinginterferon-gamma-induced cell death.{ECO:0000269|PubMed:20537536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAP_CTNND2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAP_CTNND2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DAPSETDB1CTNND2PDZD2, LRRC7, ATN1, ZBTB33, NUDT21, TTR, LNX1, CLK1, MCM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAP_CTNND2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DAP_CTNND2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDAPC0009324Ulcerative Colitis1CTD_human
TgeneCTNND2C0005586Bipolar Disorder1PSYGENET
TgeneCTNND2C0007621Neoplastic Cell Transformation1CTD_human
TgeneCTNND2C0017636Glioblastoma1CTD_human
TgeneCTNND2C0036341Schizophrenia1PSYGENET
TgeneCTNND2C0041696Unipolar Depression1PSYGENET
TgeneCTNND2C1269683Major Depressive Disorder1PSYGENET