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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9273

FusionGeneSummary for DANCR_GTF3C3

check button Fusion gene summary
Fusion gene informationFusion gene name: DANCR_GTF3C3
Fusion gene ID: 9273
HgeneTgene
Gene symbol

DANCR

GTF3C3

Gene ID

57291

9330

Gene namedifferentiation antagonizing non-protein coding RNAgeneral transcription factor IIIC subunit 3
SynonymsAGU2|ANCR|KIAA0114|SNHG13|lncRNA-ANCRTFIIIC102|TFIIICgamma|TFiiiC2-102
Cytomap

4q12

2q33.1

Type of genencRNAprotein-coding
Descriptionadipogenesis up-regulated transcript 2anti-differentiation ncRNAanti-differentiation noncoding RNAsmall nucleolar RNA host gene 13 (non-protein coding)general transcription factor 3C polypeptide 3TF3C-gammaTFIIIC 102 kDa subunitgeneral transcription factor IIIC, polypeptide 3, 102kDatranscription factor IIIC subunit gamma
Modification date2018051920180523
UniProtAcc

Q9Y5Q9

Ensembl transtripts involved in fusion geneENST00000411630, ENST00000263956, 
ENST00000409364, ENST00000470386, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 2=18
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DANCR [Title/Abstract] AND GTF3C3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-BA-A8YP-01ADANCRchr4

53579126

+GTF3C3chr2

197634763

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000411630ENST00000263956DANCRchr4

53579126

+GTF3C3chr2

197634763

-
3UTR-intronENST00000411630ENST00000409364DANCRchr4

53579126

+GTF3C3chr2

197634763

-
3UTR-intronENST00000411630ENST00000470386DANCRchr4

53579126

+GTF3C3chr2

197634763

-

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FusionProtFeatures for DANCR_GTF3C3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DANCR

GTF3C3

Q9Y5Q9

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Involved in RNA polymerase III-mediated transcription.Integral, tightly associated component of the DNA-binding TFIIIC2subcomplex that directly binds tRNA and virus-associated RNApromoters.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DANCR_GTF3C3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DANCR_GTF3C3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DANCRTRIM25, EZH2, CDK1GTF3C3MYC, GTF3C2, TBP, POLR3C, BRF1, GTF3C4, DEDD, DEDD2, PLK1, RPAP2, SQSTM1, PCBD1, EP300, SMARCAD1, SIRT7, GTF3C5, GTF3C1, GTF3C6, CPSF2, CPSF1, EPAS1, VCP, HNRNPD, CEP250, TP53, EED, RPL13, STX6, AP5M1, FBL, CASQ2, BRD7, POLR3A, RANGAP1, POLR2A, SMARCA4, SMARCC2, NTRK1, CEP19, XPO1, PCDH1, MRPL50, FOXB1, FOXG1, FOXJ2, FOXK2, FOXQ1, FOXS1, USP37, NANOG, POU5F1, POLR3D, POLR3E, CD44, ZNF785, ZNF629, BIN3, SDC2, ZNF764


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DANCR_GTF3C3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DANCR_GTF3C3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource