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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9267

FusionGeneSummary for DAGLA_POLD3

check button Fusion gene summary
Fusion gene informationFusion gene name: DAGLA_POLD3
Fusion gene ID: 9267
HgeneTgene
Gene symbol

DAGLA

POLD3

Gene ID

747

10714

Gene namediacylglycerol lipase alphaDNA polymerase delta 3, accessory subunit
SynonymsC11orf11|DAGL(ALPHA)|DAGLALPHA|NSDDRP66|P68|PPP1R128
Cytomap

11q12.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionsn1-specific diacylglycerol lipase alphaDGL-alphaneural stem cell-derived dendrite regulatorDNA polymerase delta subunit 3DNA polymerase delta subunit CDNA polymerase delta subunit p66DNA polymerase delta subunit p68Pol delta C subunit (p66)polymerase (DNA) delta 3, accessory subunitpolymerase (DNA-directed), delta 3, accessory subunitpro
Modification date2018052320180524
UniProtAcc

Q9Y4D2

Q15054

Ensembl transtripts involved in fusion geneENST00000257215, ENST00000263681, 
ENST00000527458, ENST00000532497, 
ENST00000532784, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 4 X 3=48
# samples 46
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DAGLA [Title/Abstract] AND POLD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAGLA

GO:0019369

arachidonic acid metabolic process

14610053

HgeneDAGLA

GO:0042136

neurotransmitter biosynthetic process

14610053

HgeneDAGLA

GO:0046340

diacylglycerol catabolic process

14610053


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A5ZV-01ADAGLAchr11

61447976

+POLD3chr11

74340262

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000257215ENST00000263681DAGLAchr11

61447976

+POLD3chr11

74340262

+
5UTR-3CDSENST00000257215ENST00000527458DAGLAchr11

61447976

+POLD3chr11

74340262

+
5UTR-3CDSENST00000257215ENST00000532497DAGLAchr11

61447976

+POLD3chr11

74340262

+
5UTR-intronENST00000257215ENST00000532784DAGLAchr11

61447976

+POLD3chr11

74340262

+

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FusionProtFeatures for DAGLA_POLD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAGLA

Q9Y4D2

POLD3

Q15054

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid intissues. Required for axonal growth during development and forretrograde synaptic signaling at mature synapses.{ECO:0000269|PubMed:14610053}. As a component of the trimeric and tetrameric DNApolymerase delta complexes (Pol-delta3 and Pol-delta4,respectively), plays a role in high fidelity genome replication,including in lagging strand synthesis, and repair. Required foroptimal Pol-delta activity. Stabilizes the Pol-delta complex andplays a major role in Pol-delta stimulation by PCNA(PubMed:10219083, PubMed:10852724, PubMed:11595739,PubMed:16510448, PubMed:24035200). Pol-delta3 and Pol-delta4 arecharacterized by the absence or the presence of POLD4. Theyexhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4(PubMed:19074196, PubMed:20334433). Although both Pol-delta3 andPol-delta4 process Okazaki fragments in vitro, Pol-delta3 may alsobe better suited to fulfill this task, exhibiting near-absence ofstrand displacement activity compared to Pol-delta4 and stallingon encounter with the 5'-blocking oligonucleotides. Pol-delta3idling process may avoid the formation of a gap, while maintaininga nick that can be readily ligated (PubMed:24035200). Along withDNA polymerase kappa, DNA polymerase delta carries outapproximately half of nucleotide excision repair (NER) synthesisfollowing UV irradiation. In this context, POLD3, along with PCNAand RFC1-replication factor C complex, is required to recruitPOLD1, the catalytic subunit of the polymerase delta complex, toDNA damage sites (PubMed:20227374). Under conditions of DNAreplication stress, required for the repair of broken replicationforks through break-induced replication (BIR) (PubMed:24310611).Involved in the translesion synthesis (TLS) of templates carryingO6-methylguanine or abasic sites performed by Pol-delta4,independently of DNA polymerase zeta (REV3L) or eta (POLH).Facilitates abasic site bypass by DNA polymerase delta bypromoting extension from the nucleotide inserted opposite thelesion (PubMed:19074196, PubMed:25628356, PubMed:27185888). Alsoinvolved in TLS, as a component of the POLZ complex. Along withPOLD2, dramatically increases the efficiency and processivity ofDNA synthesis of the minimal DNA polymerase zeta complex,consisting of only REV3L and REV7 (PubMed:24449906).{ECO:0000269|PubMed:10219083, ECO:0000269|PubMed:10852724,ECO:0000269|PubMed:11595739, ECO:0000269|PubMed:16510448,ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374,ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200,ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906,ECO:0000269|PubMed:25628356, ECO:0000269|PubMed:27185888}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAGLA_POLD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAGLA_POLD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DAGLAMOV10, NXF1, MCOLN3, ZNRF4POLD3PCNA, POLD2, MBD3L2, POLD1, NR2C1, DNMT1, MTA1, HDAC1, CHD4, RBBP4, SPRTN, APP, POLA1, MCM3, POLD4, TSEN2, USP8, DCP2, REV1, MAD2L2, SIRT6, TP53, XPO1, AHSA1, FAF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAGLA_POLD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DAGLA_POLD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePOLD3C0009404Colorectal Neoplasms1CTD_human