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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9260

FusionGeneSummary for DAG1_MAP4

check button Fusion gene summary
Fusion gene informationFusion gene name: DAG1_MAP4
Fusion gene ID: 9260
HgeneTgene
Gene symbol

DAG1

MAP4

Gene ID

1605

4134

Gene namedystroglycan 1microtubule associated protein 4
Synonyms156DAG|A3a|AGRNR|DAG|MDDGA9|MDDGC7|MDDGC9-
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptiondystroglycandystroglycan 1 (dystrophin-associated glycoprotein 1)microtubule-associated protein 4MAP-4
Modification date2018052220180523
UniProtAcc

Q14118

P27816

Ensembl transtripts involved in fusion geneENST00000515359, ENST00000308775, 
ENST00000541308, ENST00000539901, 
ENST00000545947, ENST00000538711, 
ENST00000479935, 		ENST00000383737, 
ENST00000395734, ENST00000426837, 
ENST00000360240, ENST00000439356, 
ENST00000264724, ENST00000420772, 
ENST00000441748, ENST00000462206, 
ENST00000434267, 
Fusion gene scores* DoF score9 X 9 X 6=4867 X 10 X 3=210
# samples 1310
** MAII scorelog2(13/486*10)=-1.90244469057733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAG1 [Title/Abstract] AND MAP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDAG1

GO:0006509

membrane protein ectodomain proteolysis

19946898

HgeneDAG1

GO:0019048

modulation by virus of host morphology or physiology

16254364


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1469-01ADAG1chr3

49571113

+MAP4chr3

47919013

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000515359ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000515359ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000515359ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000515359ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000515359ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000515359ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000515359ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000515359ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000515359ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000515359ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000308775ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000308775ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000308775ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000308775ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000308775ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000308775ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000308775ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000308775ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000308775ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000308775ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000541308ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000541308ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000541308ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000541308ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000541308ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000541308ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000541308ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000541308ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000541308ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000541308ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000539901ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000539901ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000539901ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000539901ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000539901ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000539901ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000539901ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000539901ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000539901ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000539901ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000545947ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000545947ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000545947ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000545947ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000545947ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000545947ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000545947ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000545947ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000545947ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000545947ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000538711ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000538711ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000538711ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-3CDSENST00000538711ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000538711ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000538711ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000538711ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000538711ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-5UTRENST00000538711ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
3UTR-intronENST00000538711ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-3CDSENST00000479935ENST00000383737DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-3CDSENST00000479935ENST00000395734DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-3CDSENST00000479935ENST00000426837DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-3CDSENST00000479935ENST00000360240DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-intronENST00000479935ENST00000439356DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-intronENST00000479935ENST00000264724DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-intronENST00000479935ENST00000420772DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-5UTRENST00000479935ENST00000441748DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-5UTRENST00000479935ENST00000462206DAG1chr3

49571113

+MAP4chr3

47919013

-
intron-intronENST00000479935ENST00000434267DAG1chr3

49571113

+MAP4chr3

47919013

-

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FusionProtFeatures for DAG1_MAP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAG1

Q14118

MAP4

P27816

The dystroglycan complex is involved in a number ofprocesses including laminin and basement membrane assembly,sarcolemmal stability, cell survival, peripheral nervemyelination, nodal structure, cell migration, and epithelialpolarization. Alpha-dystroglycan is an extracellular peripheralglycoprotein that acts as a receptor for both extracellular matrixproteins containing laminin-G domains. Receptor for laminin-2(LAMA2) and agrin in peripheral nerve Schwann cells. Beta-dystroglycan is a transmembrane protein that playsimportant roles in connecting the extracellular matrix to thecytoskeleton. Acts as a cell adhesion receptor in both muscle andnon-muscle tissues. Receptor for both DMD and UTRN and, throughthese interactions, scaffolds axin to the cytoskeleton. Alsofunctions in cell adhesion-mediated signaling and implicated incell polarity. (Microbial infection) Alpha-dystroglycan acts as areceptor for lassa virus and lymphocytic choriomeningitis virusglycoprotein and class C new-world arenaviruses (PubMed:16254364,PubMed:19324387, PubMed:17360738). Alpha-dystroglycan acts as aSchwann cell receptor for Mycobacterium leprae, the causativeorganism of leprosy, but only in the presence of the G-domain ofLAMA2 (PubMed:9851927). {ECO:0000269|PubMed:16254364,ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387,ECO:0000269|PubMed:9851927}. Non-neuronal microtubule-associated protein. Promotesmicrotubule assembly. {ECO:0000269|PubMed:10791892}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAG1_MAP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAG1_MAP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DAG1GRB2, RAPSN, DMD, CAV3, DRP2, PRX, SRC, FYN, CSK, NCK1, SHC1, CAV1, AGRN, UTRN, LAMA2, LAMA5, TUBA1A, ACTN1, MAP2, ITGB1, TLN1, VCL, PTK2, AGR2, AGR3, ELAVL1, SH3KBP1, CORO7, HLA-DPA1, CEACAM21, LGALS8, LGALS9, GINM1, LGALS9C, TNF, HTR3C, CLIC4, DNAJB1, PPP1CB, VPS45, KRAS, CDH1, PCDHGA5, PCDHGB4, TCTN2, PCDHB11, PCDHAC2, FKBP9, CDH5, TNFSF8, IL13RA2, TRIM25, WWC1MAP4MARK4, ENO2, CDK1, FYCO1, NR1I3, RXRB, RXRG, GSK3B, HDGF, SIRT7, SH3KBP1, ISG15, TERF1, POT1, CUL4A, USP21, GRK5, EPS15, AP2M1, RPS20, UBC, TRAF3IP1, FN1, IL7R, ERBB2IP, SNTA1, BAG3, LDLR, TARDBP, HNRNPF, COG7, CSTF2, EIF2S1, HNRNPR, IARS, MTA2, POLR2A, POLR2C, PPP4R1, WDHD1, LSM8, PDCD6, RPA3, RPA2, RPA1, LGR4, CCDC8, ABCE1, FLNB, LSM3, HSPA5, LASP1, SERBP1, SLK, NTRK1, SRPK2, KIF11, CRY2, OTUB1, CDH1, EGFR, G3BP1, BRCA1, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAG1_MAP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMAP4P27816DB01248DocetaxelMicrotubule-associated protein 4small moleculeapproved|investigational
TgeneMAP4P27816DB11638ArtenimolMicrotubule-associated protein 4small moleculeapproved|investigational
TgeneMAP4P27816DB01229PaclitaxelMicrotubule-associated protein 4small moleculeapproved|vet_approved

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RelatedDiseases for DAG1_MAP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDAG1C3151184MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (LIMB-GIRDLE), TYPE C, 92ORPHANET;UNIPROT
HgeneDAG1C0023092Lassa Fever1CTD_human
HgeneDAG1C0033578Prostatic Neoplasms1CTD_human
HgeneDAG1C4225291MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYE ANOMALIES), TYPE A, 91ORPHANET;UNIPROT
TgeneMAP4C0043094Weight Gain1CTD_human