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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9222

FusionGeneSummary for DAAM1_MNAT1

check button Fusion gene summary
Fusion gene informationFusion gene name: DAAM1_MNAT1
Fusion gene ID: 9222
HgeneTgene
Gene symbol

DAAM1

MNAT1

Gene ID

23002

4331

Gene namedishevelled associated activator of morphogenesis 1MNAT1, CDK activating kinase assembly factor
Synonyms-CAP35|MAT1|RNF66|TFB3
Cytomap

14q23.1

14q23.1

Type of geneprotein-codingprotein-coding
Descriptiondisheveled-associated activator of morphogenesis 1CDK-activating kinase assembly factor MAT1CDK7/cyclin-H assembly factorMNAT CDK-activating kinase assembly factor 1RING finger protein 66RING finger protein MAT1cyclin G1 interacting proteinmenage a trois 1 (CAK assembly factor)menage a trois homol
Modification date2018051920180523
UniProtAcc

Q9Y4D1

P51948

Ensembl transtripts involved in fusion geneENST00000360909, ENST00000351081, 
ENST00000395125, ENST00000556135, 
ENST00000553966, 
ENST00000555545, 
ENST00000261245, ENST00000539616, 
Fusion gene scores* DoF score8 X 7 X 5=2809 X 6 X 5=270
# samples 1010
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DAAM1 [Title/Abstract] AND MNAT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMNAT1

GO:0006357

regulation of transcription by RNA polymerase II

10801852

TgeneMNAT1

GO:0006366

transcription by RNA polymerase II

9852112

TgeneMNAT1

GO:0045944

positive regulation of transcription by RNA polymerase II

8692841


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-WP-A9GB-01ADAAM1chr14

59798638

+MNAT1chr14

61346432

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360909ENST00000555545DAAM1chr14

59798638

+MNAT1chr14

61346432

+
5CDS-intronENST00000360909ENST00000261245DAAM1chr14

59798638

+MNAT1chr14

61346432

+
5CDS-intronENST00000360909ENST00000539616DAAM1chr14

59798638

+MNAT1chr14

61346432

+
5CDS-intronENST00000351081ENST00000555545DAAM1chr14

59798638

+MNAT1chr14

61346432

+
5CDS-intronENST00000351081ENST00000261245DAAM1chr14

59798638

+MNAT1chr14

61346432

+
5CDS-intronENST00000351081ENST00000539616DAAM1chr14

59798638

+MNAT1chr14

61346432

+
5CDS-intronENST00000395125ENST00000555545DAAM1chr14

59798638

+MNAT1chr14

61346432

+
5CDS-intronENST00000395125ENST00000261245DAAM1chr14

59798638

+MNAT1chr14

61346432

+
5CDS-intronENST00000395125ENST00000539616DAAM1chr14

59798638

+MNAT1chr14

61346432

+
intron-intronENST00000556135ENST00000555545DAAM1chr14

59798638

+MNAT1chr14

61346432

+
intron-intronENST00000556135ENST00000261245DAAM1chr14

59798638

+MNAT1chr14

61346432

+
intron-intronENST00000556135ENST00000539616DAAM1chr14

59798638

+MNAT1chr14

61346432

+
intron-intronENST00000553966ENST00000555545DAAM1chr14

59798638

+MNAT1chr14

61346432

+
intron-intronENST00000553966ENST00000261245DAAM1chr14

59798638

+MNAT1chr14

61346432

+
intron-intronENST00000553966ENST00000539616DAAM1chr14

59798638

+MNAT1chr14

61346432

+

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FusionProtFeatures for DAAM1_MNAT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAAM1

Q9Y4D1

MNAT1

P51948

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as ascaffolding protein to recruit Rho-GDP and Rho-GEF, therebyenhancing Rho-GTP formation. Can direct nucleation and elongationof new actin filaments. Involved in building functional cilia(PubMed:16630611, PubMed:17482208). Involved in the organizationof the subapical actin network in multiciliated epithelial cells(By similarity). Together with DAAM2, required for myocardialmaturation and sarcomere assembly (By similarity).{ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0,ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. Stabilizes the cyclin H-CDK7 complex to form afunctional CDK-activating kinase (CAK) enzymatic complex. CAKactivates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6by threonine phosphorylation. CAK complexed to the core-TFIIHbasal transcription factor activates RNA polymerase II by serinephosphorylation of the repetitive C-terminal domain (CTD) of itslarge subunit (POLR2A), allowing its escape from the promoter andelongation of the transcripts. Involved in cell cycle control andin RNA transcription by RNA polymerase II.{ECO:0000269|PubMed:10024882}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAAM1_MNAT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAAM1_MNAT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DAAM1MAP3K7, PRPF40A, B3GALT4, AMBP, RHOD, GPN3, GNAZ, TMEM185A, PIFO, RHOA, CDH1, RHOC, FBXL16, SERHL2, RANBP6, FBXL14, TUBA4A, ARMC6, TUBB, SLC37A3, CHEK2, CHEK1MNAT1CCNH, ERCC3, MTA1, ESR1, CDK7, HPS6, COPS6, RBM48, EEF1A1, LRIF1, POU5F1, POU2F2, POU2F1, MCM7, RB1, TP53, DMAP1, GTF2H2, GTF2H1, SP1, ERCC2, XBP1P1, ICK, BRCA1, GTF2H3, GTF2H4, USP2, POLR2A, SUPT5H, NKX3-1, TRIM2, TRIM9, TRIML1, MKRN3, TRIM31, TRIM34, RNF32, TRIM17, RNF7, RNF41, TRIM21, TRIM39, TRIM5, MDM4, TRIM26, NGFRAP1, RPA3, RPA2, RPA1, CDK2, SFR1, HIST1H2BG, PCIF1, GTF2H5, MAGEC2, MAGEE2, SIRT6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAAM1_MNAT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DAAM1_MNAT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource