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Fusion gene ID: 9221 |
FusionGeneSummary for DAAM1_MFHAS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DAAM1_MFHAS1 | Fusion gene ID: 9221 | Hgene | Tgene | Gene symbol | DAAM1 | MFHAS1 | Gene ID | 23002 | 9258 |
| Gene name | dishevelled associated activator of morphogenesis 1 | malignant fibrous histiocytoma amplified sequence 1 | |
| Synonyms | - | LRRC65|MASL1|ROCO4 | |
| Cytomap | 14q23.1 | 8p23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | disheveled-associated activator of morphogenesis 1 | malignant fibrous histiocytoma-amplified sequence 1MFH-amplified sequences with leucine-rich tandem repeats 1leucine rich repeat containing 65malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1malignant fibrous histioc | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y4D1 | Q9Y4C4 | |
| Ensembl transtripts involved in fusion gene | ENST00000360909, ENST00000351081, ENST00000395125, ENST00000556135, ENST00000553966, | ENST00000276282, ENST00000520091, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 2 X 2 X 1=4 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: DAAM1 [Title/Abstract] AND MFHAS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CF136777 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000360909 | ENST00000276282 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| 5CDS-intron | ENST00000360909 | ENST00000520091 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| 5CDS-3UTR | ENST00000351081 | ENST00000276282 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| 5CDS-intron | ENST00000351081 | ENST00000520091 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| 5CDS-3UTR | ENST00000395125 | ENST00000276282 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| 5CDS-intron | ENST00000395125 | ENST00000520091 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| intron-3UTR | ENST00000556135 | ENST00000276282 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| intron-intron | ENST00000556135 | ENST00000520091 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| intron-3UTR | ENST00000553966 | ENST00000276282 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
| intron-intron | ENST00000553966 | ENST00000520091 | DAAM1 | chr14 | 59793689 | + | MFHAS1 | chr8 | 8643351 | - |
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FusionProtFeatures for DAAM1_MFHAS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAAM1 | MFHAS1 |
| Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as ascaffolding protein to recruit Rho-GDP and Rho-GEF, therebyenhancing Rho-GTP formation. Can direct nucleation and elongationof new actin filaments. Involved in building functional cilia(PubMed:16630611, PubMed:17482208). Involved in the organizationof the subapical actin network in multiciliated epithelial cells(By similarity). Together with DAAM2, required for myocardialmaturation and sarcomere assembly (By similarity).{ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0,ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. | Probable GTP-binding protein (PubMed:24286120).Functions in innate immunity and more specifically theinflammatory response as a regulator of the Toll-like receptorTLR2 and TLR4 signaling pathways (PubMed:26599367,PubMed:28471450, PubMed:28609714). Negatively regulates the partof the TLR4 signaling pathway that leads to the activation of thetranscription factor AP-1. By retaining the phosphatase complexPP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of thetranscription factor (PubMed:28609714). Both inhibits andactivates the TLR2-dependent signaling pathway (PubMed:26599367).Positively regulates the TLR2 signaling pathway to activatespecifically the downstream p38 and JNK MAP kinases and promotethe polarization of macrophages toward the pro-inflammatory M1phenotype (PubMed:28471450). It may also play a role in theregulation of inflammation induced by high glucose through thePKB/AKT signaling pathway (PubMed:29168081). Also involved inerythrocyte differentiation through activation of the ERK1/ERK2signaling pathway (PubMed:23327923). {ECO:0000269|PubMed:23327923,ECO:0000269|PubMed:24286120, ECO:0000269|PubMed:26599367,ECO:0000269|PubMed:28471450, ECO:0000269|PubMed:28609714,ECO:0000269|PubMed:29168081}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DAAM1_MFHAS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DAAM1_MFHAS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DAAM1_MFHAS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DAAM1_MFHAS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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