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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9219

FusionGeneSummary for DAAM1_HS6ST3

check button Fusion gene summary
Fusion gene informationFusion gene name: DAAM1_HS6ST3
Fusion gene ID: 9219
HgeneTgene
Gene symbol

DAAM1

HS6ST3

Gene ID

23002

266722

Gene namedishevelled associated activator of morphogenesis 1heparan sulfate 6-O-sulfotransferase 3
Synonyms-HS6ST-3
Cytomap

14q23.1

13q32.1

Type of geneprotein-codingprotein-coding
Descriptiondisheveled-associated activator of morphogenesis 1heparan-sulfate 6-O-sulfotransferase 3
Modification date2018051920180523
UniProtAcc

Q9Y4D1

Q8IZP7

Ensembl transtripts involved in fusion geneENST00000360909, ENST00000351081, 
ENST00000395125, ENST00000556135, 
ENST00000553966, 
ENST00000376705, 
Fusion gene scores* DoF score8 X 7 X 5=2803 X 3 X 3=27
# samples 103
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DAAM1 [Title/Abstract] AND HS6ST3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPCPGTCGA-QT-A5XN-01ADAAM1chr14

59655486

+HS6ST3chr13

97484744

+
TCGALDPCPGTCGA-QT-A5XN-01ADAAM1chr14

59655486

+HS6ST3chr13

97408109

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000360909ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97484744

+
5UTR-3CDSENST00000351081ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97484744

+
intron-3CDSENST00000395125ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97484744

+
5UTR-3CDSENST00000556135ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97484744

+
intron-3CDSENST00000553966ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97484744

+
5UTR-intronENST00000360909ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97408109

+
5UTR-intronENST00000351081ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97408109

+
intron-intronENST00000395125ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97408109

+
5UTR-intronENST00000556135ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97408109

+
intron-intronENST00000553966ENST00000376705DAAM1chr14

59655486

+HS6ST3chr13

97408109

+

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FusionProtFeatures for DAAM1_HS6ST3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DAAM1

Q9Y4D1

HS6ST3

Q8IZP7

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as ascaffolding protein to recruit Rho-GDP and Rho-GEF, therebyenhancing Rho-GTP formation. Can direct nucleation and elongationof new actin filaments. Involved in building functional cilia(PubMed:16630611, PubMed:17482208). Involved in the organizationof the subapical actin network in multiciliated epithelial cells(By similarity). Together with DAAM2, required for myocardialmaturation and sarcomere assembly (By similarity).{ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q8BPM0,ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17482208}. 6-O-sulfation enzyme which catalyzes the transfer ofsulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) toposition 6 of the N-sulfoglucosamine residue (GlcNS) of heparansulfate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DAAM1_HS6ST3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DAAM1_HS6ST3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DAAM1MAP3K7, PRPF40A, B3GALT4, AMBP, RHOD, GPN3, GNAZ, TMEM185A, PIFO, RHOA, CDH1, RHOC, FBXL16, SERHL2, RANBP6, FBXL14, TUBA4A, ARMC6, TUBB, SLC37A3, CHEK2, CHEK1HS6ST3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DAAM1_HS6ST3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DAAM1_HS6ST3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource