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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 919

FusionGeneSummary for ADNP_BMP7

check button Fusion gene summary
Fusion gene informationFusion gene name: ADNP_BMP7
Fusion gene ID: 919
HgeneTgene
Gene symbol

ADNP

BMP7

Gene ID

23394

655

Gene nameactivity dependent neuroprotector homeoboxbone morphogenetic protein 7
SynonymsADNP1|HVDAS|MRD28OP-1
Cytomap

20q13.13

20q13.31

Type of geneprotein-codingprotein-coding
Descriptionactivity-dependent neuroprotector homeobox proteinADNP homeobox 1activity-dependent neuroprotective proteinactivity-dependent neuroprotectorbone morphogenetic protein 7osteogenic protein 1
Modification date2018052220180523
UniProtAcc

Q9H2P0

P18075

Ensembl transtripts involved in fusion geneENST00000396029, ENST00000396032, 
ENST00000371602, ENST00000349014, 
ENST00000395863, ENST00000395864, 
ENST00000450594, ENST00000460817, 
Fusion gene scores* DoF score13 X 4 X 9=4681 X 1 X 1=1
# samples 131
** MAII scorelog2(13/468*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ADNP [Title/Abstract] AND BMP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBMP7

GO:0010628

positive regulation of gene expression

28124060

TgeneBMP7

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

19736306

TgeneBMP7

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

9311995|16049014|17244894|19736306

TgeneBMP7

GO:0030501

positive regulation of bone mineralization

18436533

TgeneBMP7

GO:0030509

BMP signaling pathway

16049014|18436533

TgeneBMP7

GO:0034116

positive regulation of heterotypic cell-cell adhesion

15100360

TgeneBMP7

GO:0034504

protein localization to nucleus

17244894

TgeneBMP7

GO:0042326

negative regulation of phosphorylation

17244894

TgeneBMP7

GO:0043407

negative regulation of MAP kinase activity

17244894

TgeneBMP7

GO:0045665

negative regulation of neuron differentiation

16325379

TgeneBMP7

GO:0045669

positive regulation of osteoblast differentiation

18436533

TgeneBMP7

GO:0045786

negative regulation of cell cycle

11502704

TgeneBMP7

GO:0045839

negative regulation of mitotic nuclear division

17244894

TgeneBMP7

GO:0045892

negative regulation of transcription, DNA-templated

15100360|17244894

TgeneBMP7

GO:0045893

positive regulation of transcription, DNA-templated

14517293|15100360|16049014

TgeneBMP7

GO:0048762

mesenchymal cell differentiation

9693150

TgeneBMP7

GO:0048812

neuron projection morphogenesis

16325379

TgeneBMP7

GO:0060393

regulation of pathway-restricted SMAD protein phosphorylation

16049014

TgeneBMP7

GO:0060395

SMAD protein signal transduction

17244894

TgeneBMP7

GO:0060548

negative regulation of cell death

12631064

TgeneBMP7

GO:0070487

monocyte aggregation

15100360

TgeneBMP7

GO:0072125

negative regulation of glomerular mesangial cell proliferation

17244894

TgeneBMP7

GO:1900006

positive regulation of dendrite development

11580864

TgeneBMP7

GO:1900106

positive regulation of hyaluranon cable assembly

15100360


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A196-01AADNPchr20

49547363

-BMP7chr20

55803477

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000396029ENST00000395863ADNPchr20

49547363

-BMP7chr20

55803477

-
5UTR-3CDSENST00000396029ENST00000395864ADNPchr20

49547363

-BMP7chr20

55803477

-
5UTR-3CDSENST00000396029ENST00000450594ADNPchr20

49547363

-BMP7chr20

55803477

-
5UTR-intronENST00000396029ENST00000460817ADNPchr20

49547363

-BMP7chr20

55803477

-
5UTR-3CDSENST00000396032ENST00000395863ADNPchr20

49547363

-BMP7chr20

55803477

-
5UTR-3CDSENST00000396032ENST00000395864ADNPchr20

49547363

-BMP7chr20

55803477

-
5UTR-3CDSENST00000396032ENST00000450594ADNPchr20

49547363

-BMP7chr20

55803477

-
5UTR-intronENST00000396032ENST00000460817ADNPchr20

49547363

-BMP7chr20

55803477

-
intron-3CDSENST00000371602ENST00000395863ADNPchr20

49547363

-BMP7chr20

55803477

-
intron-3CDSENST00000371602ENST00000395864ADNPchr20

49547363

-BMP7chr20

55803477

-
intron-3CDSENST00000371602ENST00000450594ADNPchr20

49547363

-BMP7chr20

55803477

-
intron-intronENST00000371602ENST00000460817ADNPchr20

49547363

-BMP7chr20

55803477

-
intron-3CDSENST00000349014ENST00000395863ADNPchr20

49547363

-BMP7chr20

55803477

-
intron-3CDSENST00000349014ENST00000395864ADNPchr20

49547363

-BMP7chr20

55803477

-
intron-3CDSENST00000349014ENST00000450594ADNPchr20

49547363

-BMP7chr20

55803477

-
intron-intronENST00000349014ENST00000460817ADNPchr20

49547363

-BMP7chr20

55803477

-

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FusionProtFeatures for ADNP_BMP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADNP

Q9H2P0

BMP7

P18075

Potential transcription factor. May mediate some of theneuroprotective peptide VIP-associated effects involving normalgrowth and cancer proliferation. Induces cartilage and bone formation. May be theosteoinductive factor responsible for the phenomenon of epithelialosteogenesis. Plays a role in calcium regulation and bonehomeostasis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADNP_BMP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADNP_BMP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADNPARID1A, SMARCC2, SMARCA4, MAP1LC3B, CBX1, CBX3, CBX5, SIRT7, SEPT2, PHGDH, EBNA1BP2, NFIA, RRS1, SAP18, EMD, MYC, HDAC1, HDAC11, CDC27, HIST3H3, CCDC8, EED, RNF2, BMI1, ILK, HDAC7, QPRT, PHF7, ZNF524, ZSCAN20, NTRK1, DAXX, KPNA1, DYNLL1, PCDHB15, ZNF644, NFATC1, RBPJ, TEAD2, FOXE1, FOXG1, FOXJ2, FOXK2, FOXQ1, FOXS1, USP37, NFATC2, ZNF581, POLG2, NCAPH2, TRIM25, TXNIP, FBXL13BMP7BMPR2, SOSTDC1, BMP7, NOG, ENG, BMPR1A, BMPR1B, ACVR1, ACVR2A, ACVR2B, SMAD1, SMAD3, ACTN4, KRTAP5-9, TRIM27, MTUS2, KRTAP10-7, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL, TAZ, TRAC, ISLR, UBR1, VWA8, GSTCD, NPTX1, AMD1, CNTNAP3B, ICK, NAAA, OLFM4, PDCD10, STK26, GDF11, DKKL1, OLFM2, GNB2, BTBD1, SLAMF1, PPP2R5D, PTPRK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADNP_BMP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADNP_BMP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADNPC0004352Autistic Disorder1CTD_human
HgeneADNPC0015923Fetal Alcohol Syndrome1PSYGENET
HgeneADNPC0036341Schizophrenia1PSYGENET
HgeneADNPC1542327Fetus or newborn affected by alcohol transmitted via placenta or breast milk1PSYGENET
TgeneBMP7C0033578Prostatic Neoplasms2CTD_human
TgeneBMP7C0005974Bone Resorption1CTD_human
TgeneBMP7C0014175Endometriosis1CTD_human
TgeneBMP7C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBMP7C0034069Pulmonary Fibrosis1CTD_human
TgeneBMP7C0038356Stomach Neoplasms1CTD_human
TgeneBMP7C0041696Unipolar Depression1PSYGENET
TgeneBMP7C1269683Major Depressive Disorder1PSYGENET