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Fusion gene ID: 9182 |
FusionGeneSummary for CYP51A1_BAIAP2L1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CYP51A1_BAIAP2L1 | Fusion gene ID: 9182 | Hgene | Tgene | Gene symbol | CYP51A1 | BAIAP2L1 | Gene ID | 1595 | 55971 |
| Gene name | cytochrome P450 family 51 subfamily A member 1 | BAI1 associated protein 2 like 1 | |
| Synonyms | CP51|CYP51|CYPL1|LDM|P450-14DM|P450L1 | IRTKS | |
| Cytomap | 7q21.2 | 7q21.3-q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lanosterol 14-alpha demethylaseCYPLIcytochrome P450 51A1cytochrome P450, 51 (lanosterol 14-alpha-demethylase)cytochrome P450, family 51, subfamily A, polypeptide 1cytochrome P450-14DMcytochrome P45014DMcytochrome P450LIsterol 14-alpha demethylase | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1BAI1-associated protein 2-like protein 1insulin receptor tyrosine kinase substrate | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q16850 | Q9UHR4 | |
| Ensembl transtripts involved in fusion gene | ENST00000003100, ENST00000450723, | ENST00000005260, ENST00000462558, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 4 X 2=56 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/56*10)=0.0995356735509144 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CYP51A1 [Title/Abstract] AND BAIAP2L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CYP51A1 | GO:0006694 | steroid biosynthetic process | 20149798 |
| Tgene | BAIAP2L1 | GO:0009617 | response to bacterium | 19366662 |
| Tgene | BAIAP2L1 | GO:0030838 | positive regulation of actin filament polymerization | 21098279 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A7-A4SD-01A | CYP51A1 | chr7 | 91752434 | - | BAIAP2L1 | chr7 | 97991744 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000003100 | ENST00000005260 | CYP51A1 | chr7 | 91752434 | - | BAIAP2L1 | chr7 | 97991744 | - |
| 5CDS-5UTR | ENST00000003100 | ENST00000462558 | CYP51A1 | chr7 | 91752434 | - | BAIAP2L1 | chr7 | 97991744 | - |
| Frame-shift | ENST00000450723 | ENST00000005260 | CYP51A1 | chr7 | 91752434 | - | BAIAP2L1 | chr7 | 97991744 | - |
| 5CDS-5UTR | ENST00000450723 | ENST00000462558 | CYP51A1 | chr7 | 91752434 | - | BAIAP2L1 | chr7 | 97991744 | - |
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FusionProtFeatures for CYP51A1_BAIAP2L1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CYP51A1 | BAIAP2L1 |
| May function as adapter protein. Involved in theformation of clusters of actin bundles. Plays a role in thereorganization of the actin cytoskeleton in response to bacterialinfection. {ECO:0000269|PubMed:17430976,ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CYP51A1 | chr7:91752434 | chr7:97991744 | ENST00000003100 | - | 7 | 10 | 24_44 | 362 | 510 | Transmembrane | Helical |
| Hgene | CYP51A1 | chr7:91752434 | chr7:97991744 | ENST00000450723 | - | 7 | 10 | 24_44 | 257 | 405 | Transmembrane | Helical |
| Tgene | >BAIAP2L1 | chr7:91752434 | chr7:97991744 | ENST00000005260 | - | 0 | 14 | 115_154 | 17 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >BAIAP2L1 | chr7:91752434 | chr7:97991744 | ENST00000005260 | - | 0 | 14 | 339_402 | 17 | 512 | Domain | SH3 |
| Tgene | >BAIAP2L1 | chr7:91752434 | chr7:97991744 | ENST00000005260 | - | 0 | 14 | 483_511 | 17 | 512 | Region | Note=Binds F-actin |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | BAIAP2L1 | chr7:91752434 | chr7:97991744 | ENST00000005260 | - | 0 | 14 | 1_249 | 17 | 512 | Domain | IMD |
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FusionGeneSequence for CYP51A1_BAIAP2L1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CYP51A1_ENST00000003100_chr7_91752434_-_BAIAP2L1_ENST00000005260_chr7_97991744_-_857aa MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEF LENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSI IEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIF YKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY DQNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTELGHVLIEISSTHKKLNESLDENFKKFHKEIIHELE KKIELDVKYMNATLKRYQTEHKNKLESLEKSQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCF LVDKHCGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPASTPVSGTPQASPMIERSNVVRKDYDTLSKCSPKMP PAPSGRAYTSPLIDMFNNPATAAPNSQRVNNSTGTSEDPSLQRSVSVATGLNMMKKQKVKTIFPHTAGSNKTLLSFAQGDVITLLIPEEK DGWLYGEHDVSKARGWFPSSYTKLLEENETEAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYLECLSMGAAADRRADSARTTSTFKAP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CYP51A1_ENST00000003100_chr7_91752434_-_BAIAP2L1_ENST00000005260_chr7_97991744_-_2571nt ATGGCGGCGGCGGCTGGGATGCTGCTGCTGGGCTTGCTGCAGGCGGGTGGGTCGGTGCTGGGCCAGGCGATGGAGAAGGTGACAGGCGGC AACCTCTTGTCCATGCTGCTGATCGCCTGCGCCTTCACCCTCAGCCTGGTCTACCTGATCCGTCTGGCCGCCGGCCACCTGGTCCAGCTG CCCGCAGGGGTGAAAAGTCCTCCATACATTTTCTCCCCAATTCCATTCCTTGGGCATGCCATAGCATTTGGGAAAAGTCCAATTGAATTT CTAGAAAATGCATATGAGAAGTATGGACCTGTATTTAGTTTTACCATGGTAGGCAAGACATTTACTTACCTTCTGGGGAGTGATGCTGCT GCACTGCTTTTTAATAGTAAAAATGAAGACCTGAATGCAGAAGATGTCTACAGTCGCCTGACAACACCTGTGTTTGGGAAGGGAGTTGCA TACGATGTGCCTAATCCAGTTTTCTTGGAGCAGAAGAAAATGTTAAAAAGTGGCCTTAACATAGCCCACTTTAAACAGCATGTTTCTATA ATTGAAAAAGAAACAAAGGAATACTTTGAGAGTTGGGGAGAAAGTGGAGAAAAAAATGTGTTTGAAGCTCTTTCTGAGCTCATAATTTTA ACAGCTAGCCATTGTTTGCATGGAAAGGAAATCAGAAGTCAACTCAATGAAAAGGTAGCACAGCTGTATGCAGATTTGGATGGAGGTTTC AGCCATGCAGCCTGGCTCTTACCAGGTTGGCTGCCTTTGCCTAGTTTCAGACGCAGGGACAGAGCTCATCGGGAAATCAAGGATATTTTC TATAAGGCAATCCAGAAACGCAGACAGTCTCAAGAAAAAATTGATGACATTCTCCAAACTTTACTAGATGCTACATACAAGGATGGGCGT CCTTTGACTGATGATGAAGTAGCAGGGATGCTTATTGGATTACTCTTGGCAGGGCAGCATACATCCTCAACTACTAGTGCTTGGATGGGC TTCTTTTTGGCCAGAGACAAAACACTTCAAAAAAAATGTTATTTAGAACAGAAAACAGTCTGTGGAGAGAATCTGCCTCCTTTAACTTAT GACCAGAATGTTATGGAACAGTTCAATCCTGGGCTGCGAAATTTAATAAACCTGGGGAAAAATTATGAGAAAGCTGTAAACGCTATGATC CTGGCAGGAAAAGCCTACTACGATGGAGTGGCCAAGATCGGTGAGATTGCCACTGGGTCCCCCGTGTCAACTGAACTGGGACATGTCCTC ATAGAGATTTCAAGTACCCACAAGAAACTCAACGAGAGTCTTGATGAAAATTTTAAAAAATTCCACAAAGAGATTATCCATGAGCTGGAG AAGAAGATAGAACTTGACGTGAAATATATGAACGCAACTCTAAAAAGATACCAAACAGAACACAAGAATAAATTAGAGTCTTTGGAGAAA TCCCAAGCTGAGTTGAAGAAGATCAGAAGGAAAAGCCAAGGAAGCCGAAACGCACTCAAATATGAACACAAAGAAATTGAGTATGTGGAG ACCGTTACTTCTCGTCAGAGTGAAATCCAGAAATTCATTGCAGATGGTTGCAAAGAGGCTCTGCTTGAAGAGAAGAGGCGCTTCTGCTTT CTGGTTGATAAGCACTGTGGCTTTGCAAACCACATACATTATTATCACTTACAGTCTGCAGAACTACTGAATTCCAAGCTGCCTCGGTGG CAGGAGACCTGTGTTGATGCCATCAAAGTGCCAGAGAAAATCATGAATATGATCGAAGAAATAAAGACCCCAGCCTCTACCCCCGTGTCT GGAACTCCTCAGGCTTCACCCATGATCGAGAGAAGCAATGTGGTTAGGAAAGATTACGACACCCTTTCTAAATGCTCACCAAAGATGCCC CCCGCTCCTTCAGGCAGAGCATATACCAGTCCCTTGATCGATATGTTTAATAACCCAGCCACGGCTGCCCCGAATTCACAAAGGGTAAAT AATTCAACAGGTACTTCCGAAGATCCCAGTTTACAGCGATCAGTTTCGGTTGCAACGGGACTGAACATGATGAAGAAGCAGAAAGTGAAG ACCATCTTCCCGCACACTGCGGGCTCCAACAAGACCTTACTCAGCTTTGCACAGGGAGATGTCATCACGCTGCTCATCCCCGAGGAGAAG GATGGCTGGCTCTATGGAGAACACGACGTGTCCAAGGCGAGGGGTTGGTTCCCGTCGTCGTACACGAAGTTGCTGGAAGAAAATGAGACA GAAGCAGTGACCGTGCCCACGCCAAGCCCCACACCAGTGAGAAGCATCAGCACCGTGAACTTGTCTGAGAATAGCAGTGTTGTCATCCCC CCACCCGACTACTTGGAATGCTTGTCCATGGGGGCAGCTGCCGACAGGAGAGCAGATTCGGCCAGGACGACATCCACCTTTAAGGCCCCA GCGTCCAAGCCCGAGACCGCGGCTCCTAACGATGCCAACGGGACTGCAAAGCCGCCTTTTCTCAGCGGAGAAAACCCCTTTGCCACTGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CYP51A1_ENST00000003100_chr7_91752434_-_BAIAP2L1_ENST00000005260_chr7_97991744_-_4607nt TTCTGTGACGCACGGGGTGGCGCGCGTGGGACCCGAGGGGTGGGGCTGGGTTTAGTAGGAGACCTGGGGCAAGGCCCCCTGTGGACGACC ATCTGCCAGCTTCTCTCGTTCCGTCGATTGGGAGGAGCGGTGGCGACCTCGGCCTTCAGTGTTTCCGACGGAGTGAATGGCGGCGGCGGC TGGGATGCTGCTGCTGGGCTTGCTGCAGGCGGGTGGGTCGGTGCTGGGCCAGGCGATGGAGAAGGTGACAGGCGGCAACCTCTTGTCCAT GCTGCTGATCGCCTGCGCCTTCACCCTCAGCCTGGTCTACCTGATCCGTCTGGCCGCCGGCCACCTGGTCCAGCTGCCCGCAGGGGTGAA AAGTCCTCCATACATTTTCTCCCCAATTCCATTCCTTGGGCATGCCATAGCATTTGGGAAAAGTCCAATTGAATTTCTAGAAAATGCATA TGAGAAGTATGGACCTGTATTTAGTTTTACCATGGTAGGCAAGACATTTACTTACCTTCTGGGGAGTGATGCTGCTGCACTGCTTTTTAA TAGTAAAAATGAAGACCTGAATGCAGAAGATGTCTACAGTCGCCTGACAACACCTGTGTTTGGGAAGGGAGTTGCATACGATGTGCCTAA TCCAGTTTTCTTGGAGCAGAAGAAAATGTTAAAAAGTGGCCTTAACATAGCCCACTTTAAACAGCATGTTTCTATAATTGAAAAAGAAAC AAAGGAATACTTTGAGAGTTGGGGAGAAAGTGGAGAAAAAAATGTGTTTGAAGCTCTTTCTGAGCTCATAATTTTAACAGCTAGCCATTG TTTGCATGGAAAGGAAATCAGAAGTCAACTCAATGAAAAGGTAGCACAGCTGTATGCAGATTTGGATGGAGGTTTCAGCCATGCAGCCTG GCTCTTACCAGGTTGGCTGCCTTTGCCTAGTTTCAGACGCAGGGACAGAGCTCATCGGGAAATCAAGGATATTTTCTATAAGGCAATCCA GAAACGCAGACAGTCTCAAGAAAAAATTGATGACATTCTCCAAACTTTACTAGATGCTACATACAAGGATGGGCGTCCTTTGACTGATGA TGAAGTAGCAGGGATGCTTATTGGATTACTCTTGGCAGGGCAGCATACATCCTCAACTACTAGTGCTTGGATGGGCTTCTTTTTGGCCAG AGACAAAACACTTCAAAAAAAATGTTATTTAGAACAGAAAACAGTCTGTGGAGAGAATCTGCCTCCTTTAACTTATGACCAGAATGTTAT GGAACAGTTCAATCCTGGGCTGCGAAATTTAATAAACCTGGGGAAAAATTATGAGAAAGCTGTAAACGCTATGATCCTGGCAGGAAAAGC CTACTACGATGGAGTGGCCAAGATCGGTGAGATTGCCACTGGGTCCCCCGTGTCAACTGAACTGGGACATGTCCTCATAGAGATTTCAAG TACCCACAAGAAACTCAACGAGAGTCTTGATGAAAATTTTAAAAAATTCCACAAAGAGATTATCCATGAGCTGGAGAAGAAGATAGAACT TGACGTGAAATATATGAACGCAACTCTAAAAAGATACCAAACAGAACACAAGAATAAATTAGAGTCTTTGGAGAAATCCCAAGCTGAGTT GAAGAAGATCAGAAGGAAAAGCCAAGGAAGCCGAAACGCACTCAAATATGAACACAAAGAAATTGAGTATGTGGAGACCGTTACTTCTCG TCAGAGTGAAATCCAGAAATTCATTGCAGATGGTTGCAAAGAGGCTCTGCTTGAAGAGAAGAGGCGCTTCTGCTTTCTGGTTGATAAGCA CTGTGGCTTTGCAAACCACATACATTATTATCACTTACAGTCTGCAGAACTACTGAATTCCAAGCTGCCTCGGTGGCAGGAGACCTGTGT TGATGCCATCAAAGTGCCAGAGAAAATCATGAATATGATCGAAGAAATAAAGACCCCAGCCTCTACCCCCGTGTCTGGAACTCCTCAGGC TTCACCCATGATCGAGAGAAGCAATGTGGTTAGGAAAGATTACGACACCCTTTCTAAATGCTCACCAAAGATGCCCCCCGCTCCTTCAGG CAGAGCATATACCAGTCCCTTGATCGATATGTTTAATAACCCAGCCACGGCTGCCCCGAATTCACAAAGGGTAAATAATTCAACAGGTAC TTCCGAAGATCCCAGTTTACAGCGATCAGTTTCGGTTGCAACGGGACTGAACATGATGAAGAAGCAGAAAGTGAAGACCATCTTCCCGCA CACTGCGGGCTCCAACAAGACCTTACTCAGCTTTGCACAGGGAGATGTCATCACGCTGCTCATCCCCGAGGAGAAGGATGGCTGGCTCTA TGGAGAACACGACGTGTCCAAGGCGAGGGGTTGGTTCCCGTCGTCGTACACGAAGTTGCTGGAAGAAAATGAGACAGAAGCAGTGACCGT GCCCACGCCAAGCCCCACACCAGTGAGAAGCATCAGCACCGTGAACTTGTCTGAGAATAGCAGTGTTGTCATCCCCCCACCCGACTACTT GGAATGCTTGTCCATGGGGGCAGCTGCCGACAGGAGAGCAGATTCGGCCAGGACGACATCCACCTTTAAGGCCCCAGCGTCCAAGCCCGA GACCGCGGCTCCTAACGATGCCAACGGGACTGCAAAGCCGCCTTTTCTCAGCGGAGAAAACCCCTTTGCCACTGTGAAACTCCGCCCGAC TGTGACGAATGATCGCTCGGCACCCATCATTCGATGAGAGGACAGCCAAGGACTCTCCCGGGCCTCTCCGGTTCTCCCTTGCGGAATGAT GGGCGCATCCTGTCTGCCACGTGCTGACGGTCGGGAAGCTTCAGTGGAGAGGCCTAACTCTAATGTCGCCTGCTTAAGCAAATCATGCTT CTCTGTTTCACGTAGTTGGGTTGACAAGTTTCTGCCTTTAAGATAAATGAGTAATAGTCTAATGACCAGCTCAGCCATTTAAAATATTTT CTTCCTATTCTGTTCAAGAAACAGTAAACTTGGTTTCAATCTTTACTGTATTTTTTAAATGAATTTTTTCCTTAATAACAGCCAGAATAA GGGATAGTCTATGCTTTCAGGACTGGCTTTCTGCACCTGATATGAATGAGACCAGTTTTATTTTATAAAGCATGTGCTCTTAATAGCATT ATGTCTAAAGAAGATATCACGTAAGTTTGCATCTTAGCATGCAAATCATAATTTTAAGCAATATAAATTATGAAAATACTATATAAATGT AATTTAACTTAAAATGTTTAAGTGTAGAGCTTCCAGAGATGGAGAAACCCCCACCCTCCCTCCAACCACGCCAGAGCTGTAGAGTGCTAA GACGCTTTGCCTGCCCTTATCACAGCCACACGTAGCACTCGACGAAATCTCCTCCGAGAGCTCCTTTTCTTGGTAGTTAGGAGTCGCCAA CGGATTCGCTGCACACGGCCCATCCAGGACACAGGCCTGGGCGTCGGAGTCACGGCTCCTTGTGTTCTCACTCAGCTAGTTGGCCAAAGC TGCATCCATTACCAGTACACTCAAACTGCTCGGGGTCCTGGTTTCTCCGTGTTTGAATCAGGTACAGACTCTCAAAGGATACGTGTAAAG CCAGGATGACCTCTGGTGCCTGGAGAAGGGCGGGTTTTTCAGCCTAGCAGCCATGATGCCCTCGGAACCTGGCCCTATGGTATGGATGTG AGGACTACGCACTGGCTGCCCTGAGCCCGGGGCTGGAAATCATCTTTGGCTGCCAAGGATCTGGACCTATTTTGGAGTGGAGAGTCATGG TTAAAATTCCCAGCCCGGCCCAGGTACGGGAATCCCAGCATTTTGTGAGGCCGAGGCAGGGGGATCACCTGAGGTCAGGAGTCTCTACTA AAAATACAAAAATTAGACAGGTGTGGTGGTGGGCGCCACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCA GTGAGCCAGATCATGCTGCTGCACTCCAGCCCGGCCGCTCACCGTGTGTGTTGCTGGGTGCTGGGGCTGTGACTTATCCCCTCTCCTTTA GCCTTGCCATAAGTGTAGTATCCTATGAGGCTGAGATTGGGAAAGGTTACATGCAGGTAAGCCAGTGGACGTGGCCGATGCTTCAGGCTC CTTCCAGCCAGGTCCAGCAGTGTTACCATCTGCTTCTCCTGGGAGGACAAACCAGGCACCCCCACCATGAAGGGGCTGCAGGCACCATGA ACTATGTTAACAACCCCAGTCTGTACTACAGAAAGGGCTGCAGCCACATGAGAATTCAGTCCACACAAGCCCCATGGCCGTGTTCCCCAC TTCAGCCACAGGGCTCAGGGAGCCCCATCTGGCGCTAAGGGGAACTGCTGGGGTGTGGGTGACACCTGGCCTTTGGCGTTCTGCCTTGGG GAGGTTTCTGGTTTTGTTACGGGGTGGAAGAATAGGACCTGGGGGTCTCGGATGCAACCTGCAGACCCCGTGGCTCACCCAACCCCAGGT TCTGCCTCCCAGACCAGAACGGGCATGGCCTGGTCCTTGGCACCGAGGTGCCTGCTCTGTAAATATCAAGGGATTACAACTTTAATAATA |
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FusionGenePPI for CYP51A1_BAIAP2L1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CYP51A1 | ELAVL1, ZNF420, SPINT2, SRPRB, MCOLN3, KCNK16, TSPAN17, CGRRF1, TREML2, FAM189A2, HTR3E, PTGER3, EVA1C, POTEI, YES1, HRAS, CCNY, EVC2, TMEM17, ACTBL2, PCDHA3, PCDHGB4, PTPRO | BAIAP2L1 | PRKAA2, PRKAB2, TERF1, TERF2, TP53, MDM2, BRD4, KHDRBS1, FASLG, VCP, EPS8, WAS, HECW2, BAIAP2, NPHP1, TMEM17, CENPJ, SORT1, TACC1, PSMD14, ZWINT, SGTB, IP6K3, BAG6, CDH1, GPRC5C, MUM1, TMEM184A, MARVELD2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CYP51A1_BAIAP2L1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CYP51A1 | Q16850 | DB00916 | Metronidazole | Lanosterol 14-alpha demethylase | small molecule | approved |
| Hgene | CYP51A1 | Q16850 | DB01007 | Tioconazole | Lanosterol 14-alpha demethylase | small molecule | approved |
| Hgene | CYP51A1 | Q16850 | DB01045 | Rifampicin | Lanosterol 14-alpha demethylase | small molecule | approved |
| Hgene | CYP51A1 | Q16850 | DB01167 | Itraconazole | Lanosterol 14-alpha demethylase | small molecule | approved|investigational |
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RelatedDiseases for CYP51A1_BAIAP2L1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | BAIAP2L1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
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