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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9175

FusionGeneSummary for CYP4F12_PTGER1

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP4F12_PTGER1
Fusion gene ID: 9175
HgeneTgene
Gene symbol

CYP4F12

PTGER1

Gene ID

66002

5731

Gene namecytochrome P450 family 4 subfamily F member 12prostaglandin E receptor 1
SynonymsCYPIVF12|F22329_1EP1
Cytomap

19p13.12

19p13.12

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 4F12cytochrome P450, family 4, subfamily F, polypeptide 12cytochrome P450, subfamily IVF, polypeptide 12prostaglandin E2 receptor EP1 subtypePGE receptor, EP1 subtypePGE2 receptor EP1 subtypeprostaglandin E receptor 1 (subtype EP1), 42kDprostaglandin E receptor 1 (subtype EP1), 42kDaprostaglandin E receptor 1, subtype EP1prostanoid EP1 receptor
Modification date2018052220180523
UniProtAcc

Q9HCS2

P34995

Ensembl transtripts involved in fusion geneENST00000550308, ENST00000324632, 
ENST00000292513, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: CYP4F12 [Title/Abstract] AND PTGER1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-RC-A6M4-01ACYP4F12chr19

15789215

+PTGER1chr19

14585149

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000550308ENST00000292513CYP4F12chr19

15789215

+PTGER1chr19

14585149

-
5CDS-5UTRENST00000324632ENST00000292513CYP4F12chr19

15789215

+PTGER1chr19

14585149

-

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FusionProtFeatures for CYP4F12_PTGER1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP4F12

Q9HCS2

PTGER1

P34995

Catalyzes leukotriene B4 omega-hydroxylation andarachidonic acid omega-hydroxylation but with an activity muchlower than that of CYP4F2. Catalyzes the hydroxylation of theantihistamine ebastine. Receptor for prostaglandin E2 (PGE2). The activity ofthis receptor is mediated by G(q) proteins which activate aphosphatidylinositol-calcium second messenger system. May play arole as an important modulator of renal function. Implicated thesmooth muscle contractile response to PGE2 in various tissues.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYP4F12_PTGER1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYP4F12_PTGER1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYP4F12SOD2, HSPA6, CYP4F2, CYP4F8, ZBTB18, POLE2PTGER1ADRB2, PTGS2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYP4F12_PTGER1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePTGER1P34995DB00429Carboprost TromethamineProstaglandin E2 receptor EP1 subtypesmall moleculeapproved
TgenePTGER1P34995DB00917DinoprostoneProstaglandin E2 receptor EP1 subtypesmall moleculeapproved
TgenePTGER1P34995DB00297BupivacaineProstaglandin E2 receptor EP1 subtypesmall moleculeapproved|investigational
TgenePTGER1P34995DB00770AlprostadilProstaglandin E2 receptor EP1 subtypesmall moleculeapproved|investigational
TgenePTGER1P34995DB00905BimatoprostProstaglandin E2 receptor EP1 subtypesmall moleculeapproved|investigational
TgenePTGER1P34995DB01088IloprostProstaglandin E2 receptor EP1 subtypesmall moleculeapproved|investigational

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RelatedDiseases for CYP4F12_PTGER1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTGER1C0001418Adenocarcinoma1CTD_human
TgenePTGER1C0007137Squamous cell carcinoma1CTD_human
TgenePTGER1C0020429Hyperalgesia1CTD_human
TgenePTGER1C0024667Animal Mammary Neoplasms1CTD_human
TgenePTGER1C0024668Mammary Neoplasms, Experimental1CTD_human
TgenePTGER1C0237873Physiological Sexual Disorders1CTD_human
TgenePTGER1C1134719Invasive Ductal Breast Carcinoma1CTD_human