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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9170

FusionGeneSummary for CYP4B1_CYP4B1

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP4B1_CYP4B1
Fusion gene ID: 9170
HgeneTgene
Gene symbol

CYP4B1

CYP4B1

Gene ID

1580

1580

Gene namecytochrome P450 family 4 subfamily B member 1cytochrome P450 family 4 subfamily B member 1
SynonymsCYPIVB1|P-450HPCYPIVB1|P-450HP
Cytomap

1p33

1p33

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 4B1cytochrome P450, family 4, subfamily B, polypeptide 1cytochrome P450, subfamily IVB, polypeptide 1cytochrome P450-HPmicrosomal monooxygenasecytochrome P450 4B1cytochrome P450, family 4, subfamily B, polypeptide 1cytochrome P450, subfamily IVB, polypeptide 1cytochrome P450-HPmicrosomal monooxygenase
Modification date2018052220180522
UniProtAcc

P13584

P13584

Ensembl transtripts involved in fusion geneENST00000546128, ENST00000371923, 
ENST00000271153, ENST00000371919, 
ENST00000452782, 
ENST00000546128, 
ENST00000371923, ENST00000271153, 
ENST00000371919, ENST00000452782, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: CYP4B1 [Title/Abstract] AND CYP4B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM968720CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000546128ENST00000546128CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-3UTRENST00000546128ENST00000371923CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-3UTRENST00000546128ENST00000271153CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-intronENST00000546128ENST00000371919CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-intronENST00000546128ENST00000452782CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-intronENST00000371923ENST00000546128CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-3UTRENST00000371923ENST00000371923CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-3UTRENST00000371923ENST00000271153CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-intronENST00000371923ENST00000371919CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-intronENST00000371923ENST00000452782CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-intronENST00000271153ENST00000546128CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-3UTRENST00000271153ENST00000371923CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-3UTRENST00000271153ENST00000271153CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-intronENST00000271153ENST00000371919CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
3UTR-intronENST00000271153ENST00000452782CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-intronENST00000371919ENST00000546128CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-3UTRENST00000371919ENST00000371923CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-3UTRENST00000371919ENST00000271153CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-intronENST00000371919ENST00000371919CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-intronENST00000371919ENST00000452782CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-intronENST00000452782ENST00000546128CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-3UTRENST00000452782ENST00000371923CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-3UTRENST00000452782ENST00000271153CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-intronENST00000452782ENST00000371919CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+
intron-intronENST00000452782ENST00000452782CYP4B1chr1

47284853

-CYP4B1chr1

47284751

+

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FusionProtFeatures for CYP4B1_CYP4B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP4B1

P13584

CYP4B1

P13584

Cytochromes P450 are a group of heme-thiolatemonooxygenases. In liver microsomes, this enzyme is involved in anNADPH-dependent electron transport pathway. It oxidizes a varietyof structurally unrelated compounds, including steroids, fattyacids, and xenobiotics. Cytochromes P450 are a group of heme-thiolatemonooxygenases. In liver microsomes, this enzyme is involved in anNADPH-dependent electron transport pathway. It oxidizes a varietyof structurally unrelated compounds, including steroids, fattyacids, and xenobiotics.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYP4B1_CYP4B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYP4B1_CYP4B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYP4B1_CYP4B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CYP4B1_CYP4B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYP4B1C0005695Bladder Neoplasm1CTD_human
TgeneCYP4B1C0005695Bladder Neoplasm1CTD_human