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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 916

FusionGeneSummary for ADNP2_L3MBTL4

check button Fusion gene summary
Fusion gene informationFusion gene name: ADNP2_L3MBTL4
Fusion gene ID: 916
HgeneTgene
Gene symbol

ADNP2

L3MBTL4

Gene ID

22850

91133

Gene nameADNP homeobox 2L3MBTL4, histone methyl-lysine binding protein
SynonymsZNF508HsT1031
Cytomap

18q23

18p11.31

Type of geneprotein-codingprotein-coding
Descriptionactivity-dependent neuroprotector homeobox protein 2ADNP homeobox protein 2zinc finger protein 508lethal(3)malignant brain tumor-like protein 4H-l(3)mbt-like protein 4L3mbt-like 4l(3)mbt-like 4l(3)mbt-like protein 4
Modification date2018051920180519
UniProtAcc

Q6IQ32

Q8NA19

Ensembl transtripts involved in fusion geneENST00000262198, ENST00000400105, 
ENST00000317931, ENST00000284898, 
ENST00000400104, ENST00000535782, 
ENST00000578677, 
Fusion gene scores* DoF score3 X 2 X 2=1210 X 8 X 5=400
# samples 310
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADNP2 [Title/Abstract] AND L3MBTL4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A7-A2KD-01AADNP2chr18

77867356

+L3MBTL4chr18

6215834

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000262198ENST00000400105ADNP2chr18

77867356

+L3MBTL4chr18

6215834

-
5UTR-3CDSENST00000262198ENST00000317931ADNP2chr18

77867356

+L3MBTL4chr18

6215834

-
5UTR-3CDSENST00000262198ENST00000284898ADNP2chr18

77867356

+L3MBTL4chr18

6215834

-
5UTR-3CDSENST00000262198ENST00000400104ADNP2chr18

77867356

+L3MBTL4chr18

6215834

-
5UTR-3CDSENST00000262198ENST00000535782ADNP2chr18

77867356

+L3MBTL4chr18

6215834

-
5UTR-intronENST00000262198ENST00000578677ADNP2chr18

77867356

+L3MBTL4chr18

6215834

-

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FusionProtFeatures for ADNP2_L3MBTL4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADNP2

Q6IQ32

L3MBTL4

Q8NA19

May be involved in transcriptional regulation. Putative Polycomb group (PcG) protein. PcG proteinsmaintain the transcriptionally repressive state of genes, probablyvia a modification of chromatin, rendering it heritably changed inits expressibility (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADNP2_L3MBTL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADNP2_L3MBTL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADNP2NFYC, CBX1, CBX5, CBX3, ELAVL1, SHMT2, MOV10, NXF1, ITPKB, MYEF2L3MBTL4APP, NINL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADNP2_L3MBTL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADNP2_L3MBTL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADNP2C0036341Schizophrenia1PSYGENET