FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 9158

FusionGeneSummary for CYP2C9_APOH

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP2C9_APOH
Fusion gene ID: 9158
HgeneTgene
Gene symbol

CYP2C9

APOH

Gene ID

1559

350

Gene namecytochrome P450 family 2 subfamily C member 9apolipoprotein H
SynonymsCPC9|CYP2C|CYP2C10|CYPIIC9|P450IIC9B2G1|B2GP1|BG
Cytomap

10q23.33

17q24.2

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 2C9cytochrome P-450 S-mephenytoin 4-hydroxylasecytochrome P-450MPcytochrome P450 PB-1cytochrome P450, family 2, subfamily C, polypeptide 9flavoprotein-linked monooxygenasemicrosomal monooxygenasexenobiotic monooxygenasebeta-2-glycoprotein 1APC inhibitorB2GPIactivated protein C-binding proteinanticardiolipin cofactorapo-Hapolipoprotein H (beta-2-glycoprotein I)beta(2)GPI
Modification date2018052320180522
UniProtAcc

P11712

P02749

Ensembl transtripts involved in fusion geneENST00000260682, ENST00000461906, 
ENST00000205948, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/8*10)=1.90689059560852
Context

PubMed: CYP2C9 [Title/Abstract] AND APOH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYP2C9

GO:0016098

monoterpenoid metabolic process

16401082

HgeneCYP2C9

GO:0017144

drug metabolic process

19219744|19651758

HgeneCYP2C9

GO:0019627

urea metabolic process

19029318

HgeneCYP2C9

GO:0032787

monocarboxylic acid metabolic process

19651758

HgeneCYP2C9

GO:0042738

exogenous drug catabolic process

18619574

HgeneCYP2C9

GO:0043603

cellular amide metabolic process

19651758

HgeneCYP2C9

GO:0055114

oxidation-reduction process

16401082|19219744

HgeneCYP2C9

GO:0070989

oxidative demethylation

18619574

TgeneAPOH

GO:0001937

negative regulation of endothelial cell proliferation

17872974

TgeneAPOH

GO:0006641

triglyceride metabolic process

7417307

TgeneAPOH

GO:0007597

blood coagulation, intrinsic pathway

4052628

TgeneAPOH

GO:0010596

negative regulation of endothelial cell migration

17872974

TgeneAPOH

GO:0016525

negative regulation of angiogenesis

17872974

TgeneAPOH

GO:0030195

negative regulation of blood coagulation

4052628

TgeneAPOH

GO:0031639

plasminogen activation

16480936

TgeneAPOH

GO:0033033

negative regulation of myeloid cell apoptotic process

15534879

TgeneAPOH

GO:0034392

negative regulation of smooth muscle cell apoptotic process

15534879

TgeneAPOH

GO:0051006

positive regulation of lipoprotein lipase activity

7417307

TgeneAPOH

GO:0051917

regulation of fibrinolysis

16480936

TgeneAPOH

GO:0051918

negative regulation of fibrinolysis

14726399


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-AAE2-01ACYP2C9chr10

96749447

+APOHchr17

64225556

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000260682ENST00000205948CYP2C9chr10

96749447

+APOHchr17

64225556

-
intron-intronENST00000461906ENST00000205948CYP2C9chr10

96749447

+APOHchr17

64225556

-

Top

FusionProtFeatures for CYP2C9_APOH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP2C9

P11712

APOH

P02749

Cytochromes P450 are a group of heme-thiolatemonooxygenases. In liver microsomes, this enzyme is involved in anNADPH-dependent electron transport pathway. It oxidizes a varietyof structurally unrelated compounds, including steroids, fattyacids, and xenobiotics (PubMed:25994031). This enzyme contributesto the wide pharmacokinetics variability of the metabolism ofdrugs such as S-warfarin, diclofenac, phenytoin, tolbutamide andlosartan (PubMed:25994031). {ECO:0000269|PubMed:25994031}. Binds to various kinds of negatively charged substancessuch as heparin, phospholipids, and dextran sulfate. May preventactivation of the intrinsic blood coagulation cascade by bindingto phospholipids on the surface of damaged cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CYP2C9_APOH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CYP2C9_APOH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYP2C9POR, CDC37, MAST1, RAB3D, RNF32, ECSIT, CYP2D6, STAT5A, STAMBP, CYP2C18, CYP3A4, CYP2C19, CD97, TOMM40APOHLRP8, LRP2, ANXA2, AKT1, CLEC4G, GRB2, TP53, GEM, CDC42, RBBP6, ATP4A, FLNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CYP2C9_APOH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCYP2C9P11712DB11994DiacereinCytochrome P450 2C9small moleculeapproved|investigational

Top

RelatedDiseases for CYP2C9_APOH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYP2C9C0019080Hemorrhage4CTD_human
HgeneCYP2C9C0041696Unipolar Depression4PSYGENET
HgeneCYP2C9C1269683Major Depressive Disorder4PSYGENET
HgeneCYP2C9C0041755Adverse reaction to drug2CTD_human
HgeneCYP2C9C4277682Chemical and Drug Induced Liver Injury2CTD_human
HgeneCYP2C9C0006118Brain Neoplasms1CTD_human
HgeneCYP2C9C0013182Drug Allergy1CTD_human
HgeneCYP2C9C0027707Nephritis, Interstitial1CTD_human
HgeneCYP2C9C0027765nervous system disorder1CTD_human
HgeneCYP2C9C0030922Peptic Ulcer Hemorrhage1CTD_human
HgeneCYP2C9C0878544Cardiomyopathies1CTD_human
HgeneCYP2C9C2609414Acute kidney injury1CTD_human
TgeneAPOHC0036341Schizophrenia1PSYGENET
TgeneAPOHC4277682Chemical and Drug Induced Liver Injury1CTD_human