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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9150

FusionGeneSummary for CYP20A1_CCDC178

check button Fusion gene summary
Fusion gene informationFusion gene name: CYP20A1_CCDC178
Fusion gene ID: 9150
HgeneTgene
Gene symbol

CYP20A1

CCDC178

Gene ID

57404

374864

Gene namecytochrome P450 family 20 subfamily A member 1coiled-coil domain containing 178
SynonymsCYP-MC18orf34
Cytomap

2q33.2

18q12.1

Type of geneprotein-codingprotein-coding
Descriptioncytochrome P450 20A1cytochrome P450 monooxygenasecytochrome P450, family 20, subfamily A, polypeptide 1coiled-coil domain-containing protein 178
Modification date2018051920180329
UniProtAcc

Q6UW02

Q5BJE1

Ensembl transtripts involved in fusion geneENST00000356079, ENST00000461371, 
ENST00000429815, 		ENST00000581852, 
ENST00000403303, ENST00000383096, 
ENST00000300227, ENST00000579916, 
ENST00000406524, ENST00000583930, 
ENST00000402325, ENST00000579947, 
ENST00000583550, 
Fusion gene scores* DoF score4 X 4 X 3=487 X 5 X 6=210
# samples 49
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYP20A1 [Title/Abstract] AND CCDC178 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-VS-A8EC-01ACYP20A1chr2

204116832

+CCDC178chr18

30795659

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356079ENST00000581852CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000403303CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000383096CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000300227CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000579916CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000406524CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000583930CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000402325CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000579947CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000356079ENST00000583550CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000581852CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000403303CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000383096CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000300227CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000579916CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000406524CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000583930CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000402325CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000579947CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
3UTR-intronENST00000461371ENST00000583550CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000581852CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000403303CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000383096CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000300227CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000579916CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000406524CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000583930CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000402325CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000579947CYP20A1chr2

204116832

+CCDC178chr18

30795659

-
5CDS-intronENST00000429815ENST00000583550CYP20A1chr2

204116832

+CCDC178chr18

30795659

-

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FusionProtFeatures for CYP20A1_CCDC178


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYP20A1

Q6UW02

CCDC178

Q5BJE1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYP20A1_CCDC178


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYP20A1_CCDC178


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYP20A1APP, TP53, PIEZO1, VSIG1, BTNL3CCDC178


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYP20A1_CCDC178


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CYP20A1_CCDC178


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource