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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9123

FusionGeneSummary for CYFIP1_SNHG14

check button Fusion gene summary
Fusion gene informationFusion gene name: CYFIP1_SNHG14
Fusion gene ID: 9123
HgeneTgene
Gene symbol

CYFIP1

SNHG14

Gene ID

23191

104472715

Gene namecytoplasmic FMR1 interacting protein 1small nucleolar RNA host gene 14
SynonymsP140SRA-1|SHYC|SRA-1|SRA1115HG|IC-SNURF-SNRPN|LNCAT|NCRNA00214|U-UBE3A-ATS|UBE3A-AS|UBE3A-AS1|UBE3AATS
Cytomap

15q11.2

15q11.2

Type of geneprotein-codingncRNA
Descriptioncytoplasmic FMR1-interacting protein 1cytoplasmic FMRP interacting protein 1selective hybridizing clonespecifically Rac1-associated protein 1UBE3A antisense RNA 1 (non-protein coding)UBE3A antisense transcriptlarge noncoding antisense transcriptsmall nucleolar RNA host gene 14 (non-protein coding)
Modification date2018052320180329
UniProtAcc

Q7L576

Ensembl transtripts involved in fusion geneENST00000313077, ENST00000560848, 
ENST00000435939, 
ENST00000549804, 
ENST00000547292, ENST00000424208, 
ENST00000452731, ENST00000554726, 
ENST00000551631, ENST00000459433, 
ENST00000551361, ENST00000553134, 
ENST00000551938, ENST00000384733, 
ENST00000551077, ENST00000546682, 
ENST00000553108, ENST00000384430, 
ENST00000516123, ENST00000553149, 
ENST00000441592, ENST00000365306, 
ENST00000414175, ENST00000456576, 
ENST00000363358, ENST00000424333, 
ENST00000450809, ENST00000453082, 
ENST00000365067, ENST00000390982, 
ENST00000580438, 
Fusion gene scores* DoF score6 X 6 X 3=1083 X 3 X 2=18
# samples 53
** MAII scorelog2(5/108*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CYFIP1 [Title/Abstract] AND SNHG14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A7-A26F-01ACYFIP1chr15

22933876

-SNHG14chr15

25663935

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000313077ENST00000549804CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000547292CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000424208CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000452731CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-3UTRENST00000313077ENST00000554726CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000551631CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000459433CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000551361CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000553134CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000551938CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000384733CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000551077CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000546682CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000553108CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000384430CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000516123CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000553149CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000441592CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000365306CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000414175CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000456576CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000363358CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000424333CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000450809CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000453082CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000365067CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000313077ENST00000390982CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-3UTRENST00000313077ENST00000580438CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000549804CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000547292CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000424208CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000452731CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-3UTRENST00000560848ENST00000554726CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000551631CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000459433CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000551361CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000553134CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000551938CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000384733CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000551077CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000546682CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000553108CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000384430CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000516123CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000553149CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000441592CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000365306CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000414175CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000456576CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000363358CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000424333CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000450809CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000453082CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000365067CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-intronENST00000560848ENST00000390982CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
5CDS-3UTRENST00000560848ENST00000580438CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000549804CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000547292CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000424208CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000452731CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-3UTRENST00000435939ENST00000554726CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000551631CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000459433CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000551361CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000553134CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000551938CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000384733CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000551077CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000546682CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000553108CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000384430CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000516123CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000553149CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000441592CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000365306CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000414175CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000456576CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000363358CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000424333CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000450809CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000453082CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000365067CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-intronENST00000435939ENST00000390982CYFIP1chr15

22933876

-SNHG14chr15

25663935

+
intron-3UTRENST00000435939ENST00000580438CYFIP1chr15

22933876

-SNHG14chr15

25663935

+

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FusionProtFeatures for CYFIP1_SNHG14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYFIP1

Q7L576

SNHG14

Component of the CYFIP1-EIF4E-FMR1 complex which bindsto the mRNA cap and mediates translational repression. In theCYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4Eand FMR1. Promotes the translation repression activity of FMR1 inbrain probably by mediating its association with EIF4E and mRNA(By similarity). Regulates formation of membrane ruffles andlamellipodia. Plays a role in axon outgrowth. Binds to F-actin butnot to RNA. Part of the WAVE complex that regulates actin filamentreorganization via its interaction with the Arp2/3 complex. Actinremodeling activity is regulated by RAC1. Regulator of epithelialmorphogenesis. As component of the WAVE1 complex, required forBDNF-NTRK2 endocytic trafficking and signaling from earlyendosomes (By similarity). May act as an invasion suppressor incancers. {ECO:0000250|UniProtKB:Q7TMB8,ECO:0000269|PubMed:16260607, ECO:0000269|PubMed:19524508,ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:9417078}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYFIP1_SNHG14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYFIP1_SNHG14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYFIP1FMR1, FXR1, FXR2, NCL, TERF1, TERF2, RYK, MARK4, YWHAH, YWHAZ, PPP1CC, RFX6, GNB1, SCTR, EFTUD2, HECW2, TCERG1, PRPF40A, APBB1, GAS7, ARHGEF1, CLUH, NCKAP1, WWOX, EFHC2, MEOX1, ZNF511, UBXN11, DTNBP1, NCK2, LHX4, BAIAP2, BZW2, ABI1, ACTR1B, CHURC1-FNTB, DCTN1, NCKAP1L, FNBP1L, TRIP10, WASF1, WASF2, NTRK1, TMEM17, PCNA, LIMA1, ARX, ZNF746, ABI2, TIMM50, AMZ1, IKBIP, WASF3, CGB2, CBLC, NHSL2, NYAP1, NYAP2, MYO16, CDH23, TRIM25, YAP1SNHG14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYFIP1_SNHG14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CYFIP1_SNHG14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYFIP1C0036341Schizophrenia1PSYGENET