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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 912

FusionGeneSummary for ADK_TAF1D

check button Fusion gene summary
Fusion gene informationFusion gene name: ADK_TAF1D
Fusion gene ID: 912
HgeneTgene
Gene symbol

ADK

TAF1D

Gene ID

132

79101

Gene nameadenosine kinaseTATA-box binding protein associated factor, RNA polymerase I subunit D
SynonymsAKJOSD3|RAFI41|TAF(I)41|TAFI41
Cytomap

10q22.2|10q11-q24

11q21

Type of geneprotein-codingprotein-coding
Descriptionadenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14TATA box-binding protein-associated factor RNA polymerase I subunit DJosephin domain containing 3RNA polymerase I-specific TBP-associated factor 41 kDaTATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDaTATA box-binding protein
Modification date2018052320180523
UniProtAcc

P55263

Q9H5J8

Ensembl transtripts involved in fusion geneENST00000539909, ENST00000286621, 
ENST00000372734, ENST00000541550, 
ENST00000467840, 
ENST00000546088, 
ENST00000448108, 
Fusion gene scores* DoF score13 X 8 X 8=8326 X 6 X 4=144
# samples 167
** MAII scorelog2(16/832*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADK [Title/Abstract] AND TAF1D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-BB-7871-01AADKchr10

75984349

+TAF1Dchr11

93465457

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000539909ENST00000546088ADKchr10

75984349

+TAF1Dchr11

93465457

-
5CDS-intronENST00000539909ENST00000448108ADKchr10

75984349

+TAF1Dchr11

93465457

-
5CDS-5UTRENST00000286621ENST00000546088ADKchr10

75984349

+TAF1Dchr11

93465457

-
5CDS-intronENST00000286621ENST00000448108ADKchr10

75984349

+TAF1Dchr11

93465457

-
5CDS-5UTRENST00000372734ENST00000546088ADKchr10

75984349

+TAF1Dchr11

93465457

-
5CDS-intronENST00000372734ENST00000448108ADKchr10

75984349

+TAF1Dchr11

93465457

-
intron-5UTRENST00000541550ENST00000546088ADKchr10

75984349

+TAF1Dchr11

93465457

-
intron-intronENST00000541550ENST00000448108ADKchr10

75984349

+TAF1Dchr11

93465457

-
intron-5UTRENST00000467840ENST00000546088ADKchr10

75984349

+TAF1Dchr11

93465457

-
intron-intronENST00000467840ENST00000448108ADKchr10

75984349

+TAF1Dchr11

93465457

-

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FusionProtFeatures for ADK_TAF1D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADK

P55263

TAF1D

Q9H5J8

Component of the transcription factor SL1/TIF-IBcomplex, which is involved in the assembly of the PIC(preinitiation complex) during RNA polymerase I-dependenttranscription. The rate of PIC formation probably is primarilydependent on the rate of association of SL1/TIF-IB with the rDNApromoter. SL1/TIF-IB is involved in stabilization of nucleolartranscription factor 1/UBTF on rDNA. Formation of SL1/TIF-IBexcludes the association of TBP with TFIID subunits.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:17318177}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADK_TAF1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADK_TAF1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADKFICD, SRD5A3, ASS1, CAPG, DAZAP1, KYNU, LDHA, PIR, PTGR1, SOD1, NNMT, NQO1, PCBP1, PITPNB, RBM12, NPLOC4, FGBTAF1DPOLB, PTN, HAP1, CENPB, CSNK2A1, CSNK2A2, CSNK2B, IPO5, TBP, TAF1C, TAF1B, TAF1A, POLR1C, PSME3, POLR1A, RRP15, RRN3, PPAN, POLR1E, POLR1B, TWISTNB, RPL6P1, UBTF, MYBBP1A, IMMT, CEP70, RPL36AL, ITFG1, HSP90AB1, FEZ1, TMSB4X, SMARCB1, EZH2, DDAH2, MCM3AP, FAM20C, ING5, UBE2D1, LRIF1, FAF1, NGEF, RPL14, EAF1, NPM1, MAPK8, NAF1, TRIM44, MECP2, RPL18A, RRP8, RBM34, RPS14, ZNF2, MCPH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADK_TAF1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADKP55263DB00811RibavirinAdenosine kinasesmall moleculeapproved

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RelatedDiseases for ADK_TAF1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADKC0036341Schizophrenia1PSYGENET
HgeneADKC0242184Hypoxia1CTD_human
HgeneADKC3280381HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY1CTD_human;ORPHANET;UNIPROT
HgeneADKC3714756Intellectual Disability1CTD_human
TgeneTAF1DC0037274Dermatologic disorders1CTD_human
TgeneTAF1DC0311375Arsenic Poisoning1CTD_human