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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9114

FusionGeneSummary for CYBRD1_SLC38A11

check button Fusion gene summary
Fusion gene informationFusion gene name: CYBRD1_SLC38A11
Fusion gene ID: 9114
HgeneTgene
Gene symbol

CYBRD1

SLC38A11

Gene ID

79901

151258

Gene namecytochrome b reductase 1solute carrier family 38 member 11
SynonymsCYB561A2|DCYTB|FRRS3AVT2
Cytomap

2q31.1

2q24.3

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b reductase 1cytochrome b561 family, member A2duodenal cytochrome bferric-chelate reductase 3putative sodium-coupled neutral amino acid transporter 11
Modification date2018052320180523
UniProtAcc

Q53TN4

Q08AI6

Ensembl transtripts involved in fusion geneENST00000409484, ENST00000468308, 
ENST00000321348, ENST00000375252, 
ENST00000303735, ENST00000409149, 
ENST00000409058, ENST00000409662, 
ENST00000493887, 
Fusion gene scores* DoF score2 X 3 X 2=125 X 4 X 6=120
# samples 37
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYBRD1 [Title/Abstract] AND SLC38A11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A25B-01ACYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000409484ENST00000303735CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
intron-3CDSENST00000409484ENST00000409149CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
intron-3CDSENST00000409484ENST00000409058CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
intron-3CDSENST00000409484ENST00000409662CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
intron-5UTRENST00000409484ENST00000493887CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
3UTR-3CDSENST00000468308ENST00000303735CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
3UTR-3CDSENST00000468308ENST00000409149CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
3UTR-3CDSENST00000468308ENST00000409058CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
3UTR-3CDSENST00000468308ENST00000409662CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
3UTR-5UTRENST00000468308ENST00000493887CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
Frame-shiftENST00000321348ENST00000303735CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
Frame-shiftENST00000321348ENST00000409149CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
Frame-shiftENST00000321348ENST00000409058CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
Frame-shiftENST00000321348ENST00000409662CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
5CDS-5UTRENST00000321348ENST00000493887CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
Frame-shiftENST00000375252ENST00000303735CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
Frame-shiftENST00000375252ENST00000409149CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
Frame-shiftENST00000375252ENST00000409058CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
Frame-shiftENST00000375252ENST00000409662CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-
5CDS-5UTRENST00000375252ENST00000493887CYBRD1chr2

172379248

+SLC38A11chr2

165772483

-

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FusionProtFeatures for CYBRD1_SLC38A11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYBRD1

Q53TN4

SLC38A11

Q08AI6

Putative sodium-dependent amino acid/proton antiporter.{ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYBRD1_SLC38A11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYBRD1_SLC38A11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYBRD1NEDD4L, STX4, CREB3, DBN1, FLNA, MYH9, PCDH7, RAB7A, IQGAP1, ACTR2, SYNPO, GOLT1B, LIMA1, MYO19, MYO18A, CDYL, MIER1, MIER2, HDAC1, HDAC2, FAM136A, LMNASLC38A11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYBRD1_SLC38A11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CYBRD1_SLC38A11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource