FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 910

FusionGeneSummary for ADK_SIRT1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADK_SIRT1
Fusion gene ID: 910
HgeneTgene
Gene symbol

ADK

SIRT1

Gene ID

132

23411

Gene nameadenosine kinasesirtuin 1
SynonymsAKSIR2|SIR2L1|SIR2alpha
Cytomap

10q22.2|10q11-q24

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionadenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14NAD-dependent protein deacetylase sirtuin-1SIR2-like protein 1regulatory protein SIR2 homolog 1sirtuin type 1
Modification date2018052320180527
UniProtAcc

P55263

Q96EB6

Ensembl transtripts involved in fusion geneENST00000539909, ENST00000286621, 
ENST00000372734, ENST00000541550, 
ENST00000467840, 
ENST00000212015, 
ENST00000497639, ENST00000432464, 
ENST00000406900, ENST00000403579, 
Fusion gene scores* DoF score13 X 8 X 8=8321 X 1 X 1=1
# samples 161
** MAII scorelog2(16/832*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ADK [Title/Abstract] AND SIRT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIRT1

GO:0000122

negative regulation of transcription by RNA polymerase II

12535671|15692560|20955178

TgeneSIRT1

GO:0000183

chromatin silencing at rDNA

18485871

TgeneSIRT1

GO:0001525

angiogenesis

20620956

TgeneSIRT1

GO:0002821

positive regulation of adaptive immune response

21890893

TgeneSIRT1

GO:0006343

establishment of chromatin silencing

15469825

TgeneSIRT1

GO:0006476

protein deacetylation

18203716|18662546|20027304|20955178

TgeneSIRT1

GO:0006974

cellular response to DNA damage stimulus

18203716

TgeneSIRT1

GO:0006979

response to oxidative stress

14976264

TgeneSIRT1

GO:0007179

transforming growth factor beta receptor signaling pathway

23960241

TgeneSIRT1

GO:0007346

regulation of mitotic cell cycle

15692560

TgeneSIRT1

GO:0016239

positive regulation of macroautophagy

18296641

TgeneSIRT1

GO:0016567

protein ubiquitination

21841822

TgeneSIRT1

GO:0016575

histone deacetylation

12006491|15469825|16079181|17172643

TgeneSIRT1

GO:0031648

protein destabilization

20955178

TgeneSIRT1

GO:0032088

negative regulation of NF-kappaB transcription factor activity

15152190

TgeneSIRT1

GO:0034983

peptidyl-lysine deacetylation

15469825

TgeneSIRT1

GO:0042542

response to hydrogen peroxide

19934257

TgeneSIRT1

GO:0043065

positive regulation of apoptotic process

15152190

TgeneSIRT1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

17680780

TgeneSIRT1

GO:0043433

negative regulation of DNA binding transcription factor activity

11672523|20955178

TgeneSIRT1

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

11672523

TgeneSIRT1

GO:0043536

positive regulation of blood vessel endothelial cell migration

23960241

TgeneSIRT1

GO:0045348

positive regulation of MHC class II biosynthetic process

21890893

TgeneSIRT1

GO:0045766

positive regulation of angiogenesis

23960241|25217442

TgeneSIRT1

GO:0045892

negative regulation of transcription, DNA-templated

11672523|20074560

TgeneSIRT1

GO:0045944

positive regulation of transcription by RNA polymerase II

12837246|21807113

TgeneSIRT1

GO:0046628

positive regulation of insulin receptor signaling pathway

21241768

TgeneSIRT1

GO:0051097

negative regulation of helicase activity

18203716

TgeneSIRT1

GO:0070301

cellular response to hydrogen peroxide

20027304

TgeneSIRT1

GO:0070932

histone H3 deacetylation

20027304

TgeneSIRT1

GO:0071356

cellular response to tumor necrosis factor

15152190

TgeneSIRT1

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

20203304

TgeneSIRT1

GO:2000757

negative regulation of peptidyl-lysine acetylation

20100829

TgeneSIRT1

GO:2000773

negative regulation of cellular senescence

20203304

TgeneSIRT1

GO:2000774

positive regulation of cellular senescence

18687677


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-P4-AAVO-01AADKchr10

75911101

+SIRT1chr10

69676022

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000539909ENST00000212015ADKchr10

75911101

+SIRT1chr10

69676022

+
5CDS-intronENST00000539909ENST00000497639ADKchr10

75911101

+SIRT1chr10

69676022

+
5CDS-intronENST00000539909ENST00000432464ADKchr10

75911101

+SIRT1chr10

69676022

+
5CDS-intronENST00000539909ENST00000406900ADKchr10

75911101

+SIRT1chr10

69676022

+
5CDS-intronENST00000539909ENST00000403579ADKchr10

75911101

+SIRT1chr10

69676022

+
Frame-shitENST00000286621ENST00000212015ADKchr10

75911101

+SIRT1chr10

69676022

+
5CDS-intronENST00000286621ENST00000497639ADKchr10

75911101

+SIRT1chr10

69676022

+
5CDS-intronENST00000286621ENST00000432464ADKchr10

75911101

+SIRT1chr10

69676022

+
5CDS-intronENST00000286621ENST00000406900ADKchr10

75911101

+SIRT1chr10

69676022

+
5CDS-intronENST00000286621ENST00000403579ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-3CDSENST00000372734ENST00000212015ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000372734ENST00000497639ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000372734ENST00000432464ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000372734ENST00000406900ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000372734ENST00000403579ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-3CDSENST00000541550ENST00000212015ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000541550ENST00000497639ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000541550ENST00000432464ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000541550ENST00000406900ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000541550ENST00000403579ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-3CDSENST00000467840ENST00000212015ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000467840ENST00000497639ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000467840ENST00000432464ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000467840ENST00000406900ADKchr10

75911101

+SIRT1chr10

69676022

+
intron-intronENST00000467840ENST00000403579ADKchr10

75911101

+SIRT1chr10

69676022

+

Top

FusionProtFeatures for ADK_SIRT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADK

P55263

SIRT1

Q96EB6

NAD-dependent protein deacetylase that linkstranscriptional regulation directly to intracellular energeticsand participates in the coordination of several separated cellularfunctions such as cell cycle, response to DNA damage, metobolism,apoptosis and autophagy. Can modulate chromatin function throughdeacetylation of histones and can promote alterations in themethylation of histones and DNA, leading to transcriptionalrepression. Deacetylates a broad range of transcription factorsand coregulators, thereby regulating target gene expressionpositively and negatively. Serves as a sensor of the cytosolicratio of NAD(+)/NADH which is altered by glucose deprivation andmetabolic changes associated with caloric restriction. Isessential in skeletal muscle cell differentiation and in responseto low nutrients mediates the inhibitory effect on skeletalmyoblast differentiation which also involves 5'-AMP-activatedprotein kinase (AMPK) and nicotinamide phosphoribosyltransferase(NAMPT). Component of the eNoSC (energy-dependent nucleolarsilencing) complex, a complex that mediates silencing of rDNA inresponse to intracellular energy status and acts by recruitinghistone-modifying enzymes. The eNoSC complex is able to sense theenergy status of cell: upon glucose starvation, elevation ofNAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2)by SUV39H1 and the formation of silent chromatin in the rDNAlocus. Deacetylates 'Lys-266' of SUV39H1, leading to itsactivation. Inhibits skeletal muscle differentiation bydeacetylating PCAF and MYOD1. Deacetylates H2A and 'Lys-26' ofHIST1H1E. Deacetylates 'Lys-16' of histone H4 (in vitro). Involvedin NR0B2/SHP corepression function through chromatin remodeling:Recruited to LRH1 target gene promoters by NR0B2/SHP therebystimulating histone H3 and H4 deacetylation leading totranscriptional repression. Proposed to contribute to genomicintegrity via positive regulation of telomere length; however,reports on localization to pericentromeric heterochromatin areconflicting. Proposed to play a role in constitutiveheterochromatin (CH) formation and/or maintenance throughregulation of the available pool of nuclear SUV39H1. Uponoxidative/metabolic stress decreases SUV39H1 degradation byinhibiting SUV39H1 polyubiquitination by MDM2. This increase inSUV39H1 levels enhances SUV39H1 turnover in CH, which in turnseems to accelerate renewal of the heterochromatin whichcorrelates with greater genomic integrity during stress response.Deacetylates 'Lys-382' of p53/TP53 and impairs its ability toinduce transcription-dependent proapoptotic program and modulatecell senescence. Deacetylates TAF1B and thereby represses rDNAtranscription by the RNA polymerase I. Deacetylates MYC, promotesthe association of MYC with MAX and decreases MYC stabilityleading to compromised transformational capability. DeacetylatesFOXO3 in response to oxidative stress thereby increasing itsability to induce cell cycle arrest and resistance to oxidativestress but inhibiting FOXO3-mediated induction of apoptosistranscriptional activity; also leading to FOXO3 ubiquitination andprotesomal degradation. Appears to have a similar effect onMLLT7/FOXO4 in regulation of transcriptional activity andapoptosis. Deacetylates DNMT1; thereby impairs DNMT1methyltransferase-independent transcription repressor activity,modulates DNMT1 cell cycle regulatory function and DNMT1-mediatedgene silencing. Deacetylates RELA/NF-kappa-B p65 therebyinhibiting its transactivating potential and augments apoptosis inresponse to TNF-alpha. Deacetylates HIF1A, KAT5/TIP60, RB1 andHIC1. Deacetylates FOXO1 resulting in its nuclear retention andenhancement of its transcriptional activity leading to increasedgluconeogenesis in liver. Inhibits E2F1 transcriptional activityand apoptotic function, possibly by deacetylation. Involved inHES1- and HEY2-mediated transcriptional repression. In cooperationwith MYCN seems to be involved in transcriptional repression ofDUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at'Ser-62'. Deacetylates MEF2D. Required for antagonist-mediatedtranscription suppression of AR-dependent genes which may belinked to local deacetylation of histone H3. Represses HNF1A-mediated transcription. Required for the repression of ESRRG byCREBZF. Modulates AP-1 transcription factor activity. DeacetylatesNR1H3 AND NR1H2 and deacetylation of NR1H3 at 'Lys-434' positivelyregulates transcription of NR1H3:RXR target genes, promotes NR1H3proteosomal degradation and results in cholesterol efflux; apromoter clearing mechanism after reach round of transcription isproposed. Involved in lipid metabolism. Implicated in regulationof adipogenesis and fat mobilization in white adipocytes byrepression of PPARG which probably involves association with NCOR1and SMRT/NCOR2. Deacetylates ACSS2 leading to its activation, andHMGCS1. Involved in liver and muscle metabolism. Throughdeacteylation and activation of PPARGC1A is required to activatefatty acid oxidation in skeletel muscle under low-glucoseconditions and is involved in glucose homeostasis. Involved inregulation of PPARA and fatty acid beta-oxidation in liver.Involved in positive regulation of insulin secretion in pancreaticbeta cells in response to glucose; the function seems to implytranscriptional repression of UCP2. Proposed to deacetylate IRS2thereby facilitating its insulin-induced tyrosine phosphorylation.Deacetylates SREBF1 isoform SREBP-1C thereby decreasing itsstability and transactivation in lipogenic gene expression.Involved in DNA damage response by repressing genes which areinvolved in DNA repair, such as XPC and TP73, deacetylatingXRCC6/Ku70, and faciliting recruitment of additional factors tosites of damaged DNA, such as SIRT1-deacetylated NBN can recruitATM to initiate DNA repair and SIRT1-deacetylated XPA interactswith RPA2. Also involved in DNA repair of DNA double-strand breaksby homologous recombination and specifically single-strandannealing independently of XRCC6/Ku70 and NBN. Transcriptionalsuppression of XPC probably involves an E2F4:RBL2 suppressorcomplex and protein kinase B (AKT) signaling. Transcriptionalsuppression of TP73 probably involves E2F4 and PCAF. DeacetylatesWRN thereby regulating its helicase and exonuclease activities andregulates WRN nuclear translocation in response to DNA damage.Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellularAP endonuclease activity by promoting the association of APEX1 toXRCC1. Increases p53/TP53-mediated transcription-independentapoptosis by blocking nuclear translocation of cytoplasmicp53/TP53 and probably redirecting it to mitochondria. DeacetylatesXRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAXaway from mitochondria thereby inhibiting stress-inducedapoptosis. Is involved in autophagy, presumably by deacetylatingATG5, ATG7 and MAP1LC3B/ATG8. Deacetylates AKT1 which leads toenhanced binding of AKT1 and PDK1 to PIP3 and promotes theiractivation. Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellularsenescence which seems to involve the regulation of theacetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 andthereby increase its activity, cytoplasmic localization andassociation with STRAD; however, the relevance of such activity innormal cells is unclear. In endothelial cells is shown to inhibitSTK11/LBK1 activity and to promote its degradation. DeacetylatesSMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation.Deacetylates CIITA and augments its MHC class II transactivationand contributes to its stability. Deacteylates MECOM/EVI1.Deacetylates PML at 'Lys-487' and this deacetylation promotes PMLcontrol of PER2 nuclear localization. During the neurogenictransition, repress selective NOTCH1-target genes through histonedeacetylation in a BCL6-dependent manner and leading to neuronaldifferentiation. Regulates the circadian expression of severalcore clock genes, including ARNTL/BMAL1, RORC, PER2 and CRY1 andplays a critical role in maintaining a controlled rhythmicity inhistone acetylation, thereby contributing to circadian chromatinremodeling. Deacetylates ARNTL/BMAL1 and histones at the circadiangene promoters in order to facilitate repression by inhibitorycomponents of the circadian oscillator. Deacetylates PER2,facilitating its ubiquitination and degradation by the proteosome.Protects cardiomyocytes against palmitate-induced apoptosis(PubMed:11672523, PubMed:12006491, PubMed:14976264,PubMed:14980222, PubMed:15126506, PubMed:15152190,PubMed:15205477, PubMed:15469825, PubMed:15692560,PubMed:16079181, PubMed:16166628, PubMed:16892051,PubMed:16998810, PubMed:17283066, PubMed:17334224,PubMed:17505061, PubMed:17612497, PubMed:17620057,PubMed:17936707, PubMed:18203716, PubMed:18296641,PubMed:18662546, PubMed:18687677, PubMed:19188449,PubMed:19220062, PubMed:19364925, PubMed:19690166,PubMed:19934257, PubMed:20097625, PubMed:20100829,PubMed:20203304, PubMed:20375098, PubMed:20620956,PubMed:20670893, PubMed:20817729, PubMed:21149730,PubMed:21245319, PubMed:21471201, PubMed:21504832,PubMed:21555002, PubMed:21698133, PubMed:21701047,PubMed:21775285, PubMed:21807113, PubMed:21841822,PubMed:21890893, PubMed:21909281, PubMed:21947282,PubMed:22274616). Deacetylates XBP1 isoform 2; deacetylationdecreases protein stability of XBP1 isoform 2 and inhibits itstranscriptional activity (PubMed:20955178). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752).Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activationof PI3K signaling (By similarity). {ECO:0000250|UniProtKB:Q923E4,ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491,ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222,ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190,ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825,ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181,ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051,ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066,ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224,ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497,ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707,ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641,ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677,ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062,ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166,ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625,ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304,ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956,ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729,ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730,ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201,ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002,ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047,ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113,ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893,ECO:0000269|PubMed:21909281, ECO:0000269|PubMed:21947282,ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:24415752,ECO:0000269|PubMed:24824780}. Isoform 2: Deacetylates 'Lys-382' of p53/TP53, howeverwith lower activity than isoform 1. In combination, the twoisoforms exert an additive effect. Isoform 2 regulates p53/TP53expression and cellular stress response and is in turn repressedby p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatoryloop. {ECO:0000269|PubMed:20975832}. (Microbial infection) In case of HIV-1 infection,interacts with and deacetylates the viral Tat protein. The viralTat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity andSIRT1 is proposed to contribute to T-cell hyperactivation duringinfection. {ECO:0000269|PubMed:18329615}. SirtT1 75 kDa fragment: Catalytically inactive 75SirT1may be involved in regulation of apoptosis. May be involved inprotecting chondrocytes from apoptotic death by associating withcytochrome C and interfering with apoptosome assembly.{ECO:0000269|PubMed:21987377}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ADK_SIRT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ADK_SIRT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADKFICD, SRD5A3, ASS1, CAPG, DAZAP1, KYNU, LDHA, PIR, PTGR1, SOD1, NNMT, NQO1, PCBP1, PITPNB, RBM12, NPLOC4, FGBSIRT1HES1, HEY2, NR1H3, NR1H2, USP22, KAT5, MAPK8, ZBTB7A, HSF1, SUV39H1, KAT2B, E2F1, NUDT21, PAPOLA, PPARGC1A, MEF2C, MYOD1, RELA, CTTN, AKIP1, AR, NCOR1, JUN, DOT1L, CLOCK, ARNTL, HDAC4, FOXO1, RRP8, EZH2, SUZ12, BCL11A, BRINP1, TP53, SIRT2, RBP1, ARID4B, ING2, ING1, FOXO4, FOXO3, BHLHE41, TLE1, ESRRA, NBN, HIC1, DVL1, DVL2, CSNK2A1, CTNNB1, MLLT3, MLLT1, NPM1, NR0B2, HNF4A, SETD7, STK4, SMAD7, MAPT, NR1H4, VDR, SREBF1, HNF1A, SKI, GAPDH, ACACA, HSPA4, WRN, HSPD1, CHCHD2, DIAPH3, YBX1, DYNC1H1, HSPA1L, HSPA5, HIST1H2BC, HIST2H2AB, HSPA9, HDAC2, CMYA5, KPNA2, KPNA3, LAMA3, EEF1G, ARHGAP29, MCF2L2, ELL3, USP9Y, NAT10, UGDH, CACNA1C, LANCL1, ATG7, ATG5, GABARAPL1, ZEB1, BRD4, MECOM, KAT8, CSNK2B, DNMT1, ESR1, STAT3, JAK1, HSP90AA1, TRIM28, KAT2A, HNRNPK, ELAVL1, SATB1, MYCN, PML, FOS, LTA4H, NUDCD2, GTF2A1, AHCY, RBM25, SMARCD2, KYNU, AKT1, ECT2, SUPT7L, ATXN7L3, CREB1, RPS19BP1, PUS7, SPDL1, TULP3, PIP5K1A, PHLDB3, AKIRIN2, IQCB1, JUND, ZNHIT6, KRT79, WDR70, NOP14, PICALM, SERPINB4, ARRB2, TSPYL1, RECQL4, SCNM1, ZNF346, NOC4L, SART1, TAF2, RAP1A, CHD3, RPTOR, MTOR, CDK6, EED, DNMT3B, UVSSA, CDKL1, CAP1, FASN, KIAA1598, TPM4, POP1, PPARA, KCNA5, KCNA4, KCNAB2, EP300, VHL, PSME3, STK11, CDK1, CCNB1, IRS2, IRS1, UBE2I, PARP1, FOXP3, HIST1H3A, RICTOR, EPAS1, CSNK2A2, NMNAT1, APEX1, SNW1, RARA, TSC2, NOS3, SIRT1, RB1, TP73, PIK3R1, MTA1, HOXB5, RPL6, RPS2, AKR1D1, FGF10, CWC15, ZBTB38, TADA2B, SFRP4, CCAR2, CHEK2, MCM10, EWSR1, CEP44, THOC5, LRPPRC, FBXO7, SMEK1, HNRNPA1L2, USP37, MPHOSPH8, MYC, ZMIZ1, ZYX, FOXL2, CHFR, HERC2, MDM2, NDN, CERKL, ZNF263, SOST, RBFA, ZNF785, CLK3, APEX2, ZNF550, VWA3B, ZNF354C, MTFR2, ZNF669, TBCCD1, ZNF707, TNNI2, PTPN4, HOXB9, SIRT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ADK_SIRT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADKP55263DB00811RibavirinAdenosine kinasesmall moleculeapproved

Top

RelatedDiseases for ADK_SIRT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADKC0036341Schizophrenia1PSYGENET
HgeneADKC0242184Hypoxia1CTD_human
HgeneADKC3280381HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY1CTD_human;ORPHANET;UNIPROT
HgeneADKC3714756Intellectual Disability1CTD_human
TgeneSIRT1C0015695Fatty Liver5CTD_human
TgeneSIRT1C0021655Insulin Resistance5CTD_human
TgeneSIRT1C0009319Colitis3CTD_human
TgeneSIRT1C0005586Bipolar Disorder2PSYGENET
TgeneSIRT1C0011853Diabetes Mellitus, Experimental2CTD_human
TgeneSIRT1C0036341Schizophrenia2PSYGENET
TgeneSIRT1C0524851Neurodegenerative Disorders2CTD_human
TgeneSIRT1C0525045Mood Disorders2PSYGENET
TgeneSIRT1C0004153Atherosclerosis1CTD_human
TgeneSIRT1C0004364Autoimmune Diseases1CTD_human
TgeneSIRT1C0006118Brain Neoplasms1CTD_human
TgeneSIRT1C0011303Demyelinating Diseases1CTD_human
TgeneSIRT1C0011849Diabetes Mellitus1CTD_human
TgeneSIRT1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneSIRT1C0011884Diabetic Retinopathy1CTD_human
TgeneSIRT1C0014072Experimental Autoimmune Encephalomyelitis1CTD_human
TgeneSIRT1C0016059Fibrosis1CTD_human
TgeneSIRT1C0018799Heart Diseases1CTD_human
TgeneSIRT1C0018801Heart failure1CTD_human
TgeneSIRT1C0019693HIV Infections1CTD_human
TgeneSIRT1C0020564Hypertrophy1CTD_human
TgeneSIRT1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSIRT1C0027055Myocardial Reperfusion Injury1CTD_human
TgeneSIRT1C0027746Nerve Degeneration1CTD_human
TgeneSIRT1C0028754Obesity1CTD_human
TgeneSIRT1C0032285Pneumonia1CTD_human
TgeneSIRT1C0033578Prostatic Neoplasms1CTD_human
TgeneSIRT1C0033937Psychoses, Drug1PSYGENET
TgeneSIRT1C0035309Retinal Diseases1CTD_human
TgeneSIRT1C0036421Systemic Scleroderma1CTD_human
TgeneSIRT1C0036939Shared Paranoid Disorder1PSYGENET
TgeneSIRT1C0040053Thrombosis1CTD_human
TgeneSIRT1C0043020Wallerian Degeneration1CTD_human
TgeneSIRT1C0085762Alcohol abuse1PSYGENET
TgeneSIRT1C0155862Streptococcal pneumonia1CTD_human
TgeneSIRT1C0271650Impaired glucose tolerance1CTD_human
TgeneSIRT1C0273115Lung Injury1CTD_human
TgeneSIRT1C0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneSIRT1C0522224Paralysed1CTD_human
TgeneSIRT1C0524620Metabolic Syndrome X1CTD_human
TgeneSIRT1C0751955Brain Infarction1CTD_human
TgeneSIRT1C0919532Genomic Instability1CTD_human
TgeneSIRT1C1458155Mammary Neoplasms1CTD_human
TgeneSIRT1C2609414Acute kidney injury1CTD_human
TgeneSIRT1C2931673Ceroid lipofuscinosis, neuronal 1, infantile1CTD_human