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Fusion gene ID: 910 |
FusionGeneSummary for ADK_SIRT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADK_SIRT1 | Fusion gene ID: 910 | Hgene | Tgene | Gene symbol | ADK | SIRT1 | Gene ID | 132 | 23411 |
| Gene name | adenosine kinase | sirtuin 1 | |
| Synonyms | AK | SIR2|SIR2L1|SIR2alpha | |
| Cytomap | 10q22.2|10q11-q24 | 10q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14 | NAD-dependent protein deacetylase sirtuin-1SIR2-like protein 1regulatory protein SIR2 homolog 1sirtuin type 1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P55263 | Q96EB6 | |
| Ensembl transtripts involved in fusion gene | ENST00000539909, ENST00000286621, ENST00000372734, ENST00000541550, ENST00000467840, | ENST00000212015, ENST00000497639, ENST00000432464, ENST00000406900, ENST00000403579, | |
| Fusion gene scores | * DoF score | 13 X 8 X 8=832 | 1 X 1 X 1=1 |
| # samples | 16 | 1 | |
| ** MAII score | log2(16/832*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ADK [Title/Abstract] AND SIRT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SIRT1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12535671|15692560|20955178 |
| Tgene | SIRT1 | GO:0000183 | chromatin silencing at rDNA | 18485871 |
| Tgene | SIRT1 | GO:0001525 | angiogenesis | 20620956 |
| Tgene | SIRT1 | GO:0002821 | positive regulation of adaptive immune response | 21890893 |
| Tgene | SIRT1 | GO:0006343 | establishment of chromatin silencing | 15469825 |
| Tgene | SIRT1 | GO:0006476 | protein deacetylation | 18203716|18662546|20027304|20955178 |
| Tgene | SIRT1 | GO:0006974 | cellular response to DNA damage stimulus | 18203716 |
| Tgene | SIRT1 | GO:0006979 | response to oxidative stress | 14976264 |
| Tgene | SIRT1 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 23960241 |
| Tgene | SIRT1 | GO:0007346 | regulation of mitotic cell cycle | 15692560 |
| Tgene | SIRT1 | GO:0016239 | positive regulation of macroautophagy | 18296641 |
| Tgene | SIRT1 | GO:0016567 | protein ubiquitination | 21841822 |
| Tgene | SIRT1 | GO:0016575 | histone deacetylation | 12006491|15469825|16079181|17172643 |
| Tgene | SIRT1 | GO:0031648 | protein destabilization | 20955178 |
| Tgene | SIRT1 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 15152190 |
| Tgene | SIRT1 | GO:0034983 | peptidyl-lysine deacetylation | 15469825 |
| Tgene | SIRT1 | GO:0042542 | response to hydrogen peroxide | 19934257 |
| Tgene | SIRT1 | GO:0043065 | positive regulation of apoptotic process | 15152190 |
| Tgene | SIRT1 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 17680780 |
| Tgene | SIRT1 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 11672523|20955178 |
| Tgene | SIRT1 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 11672523 |
| Tgene | SIRT1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 23960241 |
| Tgene | SIRT1 | GO:0045348 | positive regulation of MHC class II biosynthetic process | 21890893 |
| Tgene | SIRT1 | GO:0045766 | positive regulation of angiogenesis | 23960241|25217442 |
| Tgene | SIRT1 | GO:0045892 | negative regulation of transcription, DNA-templated | 11672523|20074560 |
| Tgene | SIRT1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12837246|21807113 |
| Tgene | SIRT1 | GO:0046628 | positive regulation of insulin receptor signaling pathway | 21241768 |
| Tgene | SIRT1 | GO:0051097 | negative regulation of helicase activity | 18203716 |
| Tgene | SIRT1 | GO:0070301 | cellular response to hydrogen peroxide | 20027304 |
| Tgene | SIRT1 | GO:0070932 | histone H3 deacetylation | 20027304 |
| Tgene | SIRT1 | GO:0071356 | cellular response to tumor necrosis factor | 15152190 |
| Tgene | SIRT1 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | 20203304 |
| Tgene | SIRT1 | GO:2000757 | negative regulation of peptidyl-lysine acetylation | 20100829 |
| Tgene | SIRT1 | GO:2000773 | negative regulation of cellular senescence | 20203304 |
| Tgene | SIRT1 | GO:2000774 | positive regulation of cellular senescence | 18687677 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-P4-AAVO-01A | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000539909 | ENST00000212015 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| 5CDS-intron | ENST00000539909 | ENST00000497639 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| 5CDS-intron | ENST00000539909 | ENST00000432464 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| 5CDS-intron | ENST00000539909 | ENST00000406900 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| 5CDS-intron | ENST00000539909 | ENST00000403579 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| Frame-shift | ENST00000286621 | ENST00000212015 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| 5CDS-intron | ENST00000286621 | ENST00000497639 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| 5CDS-intron | ENST00000286621 | ENST00000432464 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| 5CDS-intron | ENST00000286621 | ENST00000406900 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| 5CDS-intron | ENST00000286621 | ENST00000403579 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-3CDS | ENST00000372734 | ENST00000212015 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000372734 | ENST00000497639 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000372734 | ENST00000432464 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000372734 | ENST00000406900 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000372734 | ENST00000403579 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-3CDS | ENST00000541550 | ENST00000212015 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000541550 | ENST00000497639 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000541550 | ENST00000432464 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000541550 | ENST00000406900 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000541550 | ENST00000403579 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-3CDS | ENST00000467840 | ENST00000212015 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000467840 | ENST00000497639 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000467840 | ENST00000432464 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000467840 | ENST00000406900 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
| intron-intron | ENST00000467840 | ENST00000403579 | ADK | chr10 | 75911101 | + | SIRT1 | chr10 | 69676022 | + |
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FusionProtFeatures for ADK_SIRT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADK | SIRT1 |
| NAD-dependent protein deacetylase that linkstranscriptional regulation directly to intracellular energeticsand participates in the coordination of several separated cellularfunctions such as cell cycle, response to DNA damage, metobolism,apoptosis and autophagy. Can modulate chromatin function throughdeacetylation of histones and can promote alterations in themethylation of histones and DNA, leading to transcriptionalrepression. Deacetylates a broad range of transcription factorsand coregulators, thereby regulating target gene expressionpositively and negatively. Serves as a sensor of the cytosolicratio of NAD(+)/NADH which is altered by glucose deprivation andmetabolic changes associated with caloric restriction. Isessential in skeletal muscle cell differentiation and in responseto low nutrients mediates the inhibitory effect on skeletalmyoblast differentiation which also involves 5'-AMP-activatedprotein kinase (AMPK) and nicotinamide phosphoribosyltransferase(NAMPT). Component of the eNoSC (energy-dependent nucleolarsilencing) complex, a complex that mediates silencing of rDNA inresponse to intracellular energy status and acts by recruitinghistone-modifying enzymes. The eNoSC complex is able to sense theenergy status of cell: upon glucose starvation, elevation ofNAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2)by SUV39H1 and the formation of silent chromatin in the rDNAlocus. Deacetylates 'Lys-266' of SUV39H1, leading to itsactivation. Inhibits skeletal muscle differentiation bydeacetylating PCAF and MYOD1. Deacetylates H2A and 'Lys-26' ofHIST1H1E. Deacetylates 'Lys-16' of histone H4 (in vitro). Involvedin NR0B2/SHP corepression function through chromatin remodeling:Recruited to LRH1 target gene promoters by NR0B2/SHP therebystimulating histone H3 and H4 deacetylation leading totranscriptional repression. Proposed to contribute to genomicintegrity via positive regulation of telomere length; however,reports on localization to pericentromeric heterochromatin areconflicting. Proposed to play a role in constitutiveheterochromatin (CH) formation and/or maintenance throughregulation of the available pool of nuclear SUV39H1. Uponoxidative/metabolic stress decreases SUV39H1 degradation byinhibiting SUV39H1 polyubiquitination by MDM2. This increase inSUV39H1 levels enhances SUV39H1 turnover in CH, which in turnseems to accelerate renewal of the heterochromatin whichcorrelates with greater genomic integrity during stress response.Deacetylates 'Lys-382' of p53/TP53 and impairs its ability toinduce transcription-dependent proapoptotic program and modulatecell senescence. Deacetylates TAF1B and thereby represses rDNAtranscription by the RNA polymerase I. Deacetylates MYC, promotesthe association of MYC with MAX and decreases MYC stabilityleading to compromised transformational capability. DeacetylatesFOXO3 in response to oxidative stress thereby increasing itsability to induce cell cycle arrest and resistance to oxidativestress but inhibiting FOXO3-mediated induction of apoptosistranscriptional activity; also leading to FOXO3 ubiquitination andprotesomal degradation. Appears to have a similar effect onMLLT7/FOXO4 in regulation of transcriptional activity andapoptosis. Deacetylates DNMT1; thereby impairs DNMT1methyltransferase-independent transcription repressor activity,modulates DNMT1 cell cycle regulatory function and DNMT1-mediatedgene silencing. Deacetylates RELA/NF-kappa-B p65 therebyinhibiting its transactivating potential and augments apoptosis inresponse to TNF-alpha. Deacetylates HIF1A, KAT5/TIP60, RB1 andHIC1. Deacetylates FOXO1 resulting in its nuclear retention andenhancement of its transcriptional activity leading to increasedgluconeogenesis in liver. Inhibits E2F1 transcriptional activityand apoptotic function, possibly by deacetylation. Involved inHES1- and HEY2-mediated transcriptional repression. In cooperationwith MYCN seems to be involved in transcriptional repression ofDUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at'Ser-62'. Deacetylates MEF2D. Required for antagonist-mediatedtranscription suppression of AR-dependent genes which may belinked to local deacetylation of histone H3. Represses HNF1A-mediated transcription. Required for the repression of ESRRG byCREBZF. Modulates AP-1 transcription factor activity. DeacetylatesNR1H3 AND NR1H2 and deacetylation of NR1H3 at 'Lys-434' positivelyregulates transcription of NR1H3:RXR target genes, promotes NR1H3proteosomal degradation and results in cholesterol efflux; apromoter clearing mechanism after reach round of transcription isproposed. Involved in lipid metabolism. Implicated in regulationof adipogenesis and fat mobilization in white adipocytes byrepression of PPARG which probably involves association with NCOR1and SMRT/NCOR2. Deacetylates ACSS2 leading to its activation, andHMGCS1. Involved in liver and muscle metabolism. Throughdeacteylation and activation of PPARGC1A is required to activatefatty acid oxidation in skeletel muscle under low-glucoseconditions and is involved in glucose homeostasis. Involved inregulation of PPARA and fatty acid beta-oxidation in liver.Involved in positive regulation of insulin secretion in pancreaticbeta cells in response to glucose; the function seems to implytranscriptional repression of UCP2. Proposed to deacetylate IRS2thereby facilitating its insulin-induced tyrosine phosphorylation.Deacetylates SREBF1 isoform SREBP-1C thereby decreasing itsstability and transactivation in lipogenic gene expression.Involved in DNA damage response by repressing genes which areinvolved in DNA repair, such as XPC and TP73, deacetylatingXRCC6/Ku70, and faciliting recruitment of additional factors tosites of damaged DNA, such as SIRT1-deacetylated NBN can recruitATM to initiate DNA repair and SIRT1-deacetylated XPA interactswith RPA2. Also involved in DNA repair of DNA double-strand breaksby homologous recombination and specifically single-strandannealing independently of XRCC6/Ku70 and NBN. Transcriptionalsuppression of XPC probably involves an E2F4:RBL2 suppressorcomplex and protein kinase B (AKT) signaling. Transcriptionalsuppression of TP73 probably involves E2F4 and PCAF. DeacetylatesWRN thereby regulating its helicase and exonuclease activities andregulates WRN nuclear translocation in response to DNA damage.Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellularAP endonuclease activity by promoting the association of APEX1 toXRCC1. Increases p53/TP53-mediated transcription-independentapoptosis by blocking nuclear translocation of cytoplasmicp53/TP53 and probably redirecting it to mitochondria. DeacetylatesXRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAXaway from mitochondria thereby inhibiting stress-inducedapoptosis. Is involved in autophagy, presumably by deacetylatingATG5, ATG7 and MAP1LC3B/ATG8. Deacetylates AKT1 which leads toenhanced binding of AKT1 and PDK1 to PIP3 and promotes theiractivation. Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellularsenescence which seems to involve the regulation of theacetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 andthereby increase its activity, cytoplasmic localization andassociation with STRAD; however, the relevance of such activity innormal cells is unclear. In endothelial cells is shown to inhibitSTK11/LBK1 activity and to promote its degradation. DeacetylatesSMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation.Deacetylates CIITA and augments its MHC class II transactivationand contributes to its stability. Deacteylates MECOM/EVI1.Deacetylates PML at 'Lys-487' and this deacetylation promotes PMLcontrol of PER2 nuclear localization. During the neurogenictransition, repress selective NOTCH1-target genes through histonedeacetylation in a BCL6-dependent manner and leading to neuronaldifferentiation. Regulates the circadian expression of severalcore clock genes, including ARNTL/BMAL1, RORC, PER2 and CRY1 andplays a critical role in maintaining a controlled rhythmicity inhistone acetylation, thereby contributing to circadian chromatinremodeling. Deacetylates ARNTL/BMAL1 and histones at the circadiangene promoters in order to facilitate repression by inhibitorycomponents of the circadian oscillator. Deacetylates PER2,facilitating its ubiquitination and degradation by the proteosome.Protects cardiomyocytes against palmitate-induced apoptosis(PubMed:11672523, PubMed:12006491, PubMed:14976264,PubMed:14980222, PubMed:15126506, PubMed:15152190,PubMed:15205477, PubMed:15469825, PubMed:15692560,PubMed:16079181, PubMed:16166628, PubMed:16892051,PubMed:16998810, PubMed:17283066, PubMed:17334224,PubMed:17505061, PubMed:17612497, PubMed:17620057,PubMed:17936707, PubMed:18203716, PubMed:18296641,PubMed:18662546, PubMed:18687677, PubMed:19188449,PubMed:19220062, PubMed:19364925, PubMed:19690166,PubMed:19934257, PubMed:20097625, PubMed:20100829,PubMed:20203304, PubMed:20375098, PubMed:20620956,PubMed:20670893, PubMed:20817729, PubMed:21149730,PubMed:21245319, PubMed:21471201, PubMed:21504832,PubMed:21555002, PubMed:21698133, PubMed:21701047,PubMed:21775285, PubMed:21807113, PubMed:21841822,PubMed:21890893, PubMed:21909281, PubMed:21947282,PubMed:22274616). Deacetylates XBP1 isoform 2; deacetylationdecreases protein stability of XBP1 isoform 2 and inhibits itstranscriptional activity (PubMed:20955178). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752).Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activationof PI3K signaling (By similarity). {ECO:0000250|UniProtKB:Q923E4,ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491,ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222,ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190,ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825,ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181,ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051,ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066,ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224,ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497,ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707,ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641,ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677,ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062,ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166,ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625,ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304,ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956,ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729,ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730,ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201,ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002,ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047,ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113,ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893,ECO:0000269|PubMed:21909281, ECO:0000269|PubMed:21947282,ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:24415752,ECO:0000269|PubMed:24824780}. Isoform 2: Deacetylates 'Lys-382' of p53/TP53, howeverwith lower activity than isoform 1. In combination, the twoisoforms exert an additive effect. Isoform 2 regulates p53/TP53expression and cellular stress response and is in turn repressedby p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatoryloop. {ECO:0000269|PubMed:20975832}. (Microbial infection) In case of HIV-1 infection,interacts with and deacetylates the viral Tat protein. The viralTat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity andSIRT1 is proposed to contribute to T-cell hyperactivation duringinfection. {ECO:0000269|PubMed:18329615}. SirtT1 75 kDa fragment: Catalytically inactive 75SirT1may be involved in regulation of apoptosis. May be involved inprotecting chondrocytes from apoptotic death by associating withcytochrome C and interfering with apoptosome assembly.{ECO:0000269|PubMed:21987377}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADK_SIRT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADK_SIRT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADK | FICD, SRD5A3, ASS1, CAPG, DAZAP1, KYNU, LDHA, PIR, PTGR1, SOD1, NNMT, NQO1, PCBP1, PITPNB, RBM12, NPLOC4, FGB | SIRT1 | HES1, HEY2, NR1H3, NR1H2, USP22, KAT5, MAPK8, ZBTB7A, HSF1, SUV39H1, KAT2B, E2F1, NUDT21, PAPOLA, PPARGC1A, MEF2C, MYOD1, RELA, CTTN, AKIP1, AR, NCOR1, JUN, DOT1L, CLOCK, ARNTL, HDAC4, FOXO1, RRP8, EZH2, SUZ12, BCL11A, BRINP1, TP53, SIRT2, RBP1, ARID4B, ING2, ING1, FOXO4, FOXO3, BHLHE41, TLE1, ESRRA, NBN, HIC1, DVL1, DVL2, CSNK2A1, CTNNB1, MLLT3, MLLT1, NPM1, NR0B2, HNF4A, SETD7, STK4, SMAD7, MAPT, NR1H4, VDR, SREBF1, HNF1A, SKI, GAPDH, ACACA, HSPA4, WRN, HSPD1, CHCHD2, DIAPH3, YBX1, DYNC1H1, HSPA1L, HSPA5, HIST1H2BC, HIST2H2AB, HSPA9, HDAC2, CMYA5, KPNA2, KPNA3, LAMA3, EEF1G, ARHGAP29, MCF2L2, ELL3, USP9Y, NAT10, UGDH, CACNA1C, LANCL1, ATG7, ATG5, GABARAPL1, ZEB1, BRD4, MECOM, KAT8, CSNK2B, DNMT1, ESR1, STAT3, JAK1, HSP90AA1, TRIM28, KAT2A, HNRNPK, ELAVL1, SATB1, MYCN, PML, FOS, LTA4H, NUDCD2, GTF2A1, AHCY, RBM25, SMARCD2, KYNU, AKT1, ECT2, SUPT7L, ATXN7L3, CREB1, RPS19BP1, PUS7, SPDL1, TULP3, PIP5K1A, PHLDB3, AKIRIN2, IQCB1, JUND, ZNHIT6, KRT79, WDR70, NOP14, PICALM, SERPINB4, ARRB2, TSPYL1, RECQL4, SCNM1, ZNF346, NOC4L, SART1, TAF2, RAP1A, CHD3, RPTOR, MTOR, CDK6, EED, DNMT3B, UVSSA, CDKL1, CAP1, FASN, KIAA1598, TPM4, POP1, PPARA, KCNA5, KCNA4, KCNAB2, EP300, VHL, PSME3, STK11, CDK1, CCNB1, IRS2, IRS1, UBE2I, PARP1, FOXP3, HIST1H3A, RICTOR, EPAS1, CSNK2A2, NMNAT1, APEX1, SNW1, RARA, TSC2, NOS3, SIRT1, RB1, TP73, PIK3R1, MTA1, HOXB5, RPL6, RPS2, AKR1D1, FGF10, CWC15, ZBTB38, TADA2B, SFRP4, CCAR2, CHEK2, MCM10, EWSR1, CEP44, THOC5, LRPPRC, FBXO7, SMEK1, HNRNPA1L2, USP37, MPHOSPH8, MYC, ZMIZ1, ZYX, FOXL2, CHFR, HERC2, MDM2, NDN, CERKL, ZNF263, SOST, RBFA, ZNF785, CLK3, APEX2, ZNF550, VWA3B, ZNF354C, MTFR2, ZNF669, TBCCD1, ZNF707, TNNI2, PTPN4, HOXB9, SIRT7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADK_SIRT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ADK | P55263 | DB00811 | Ribavirin | Adenosine kinase | small molecule | approved |
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RelatedDiseases for ADK_SIRT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADK | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | ADK | C0242184 | Hypoxia | 1 | CTD_human |
| Hgene | ADK | C3280381 | HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY | 1 | CTD_human;ORPHANET;UNIPROT |
| Hgene | ADK | C3714756 | Intellectual Disability | 1 | CTD_human |
| Tgene | SIRT1 | C0015695 | Fatty Liver | 5 | CTD_human |
| Tgene | SIRT1 | C0021655 | Insulin Resistance | 5 | CTD_human |
| Tgene | SIRT1 | C0009319 | Colitis | 3 | CTD_human |
| Tgene | SIRT1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | SIRT1 | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
| Tgene | SIRT1 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | SIRT1 | C0524851 | Neurodegenerative Disorders | 2 | CTD_human |
| Tgene | SIRT1 | C0525045 | Mood Disorders | 2 | PSYGENET |
| Tgene | SIRT1 | C0004153 | Atherosclerosis | 1 | CTD_human |
| Tgene | SIRT1 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
| Tgene | SIRT1 | C0006118 | Brain Neoplasms | 1 | CTD_human |
| Tgene | SIRT1 | C0011303 | Demyelinating Diseases | 1 | CTD_human |
| Tgene | SIRT1 | C0011849 | Diabetes Mellitus | 1 | CTD_human |
| Tgene | SIRT1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Tgene | SIRT1 | C0011884 | Diabetic Retinopathy | 1 | CTD_human |
| Tgene | SIRT1 | C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | CTD_human |
| Tgene | SIRT1 | C0016059 | Fibrosis | 1 | CTD_human |
| Tgene | SIRT1 | C0018799 | Heart Diseases | 1 | CTD_human |
| Tgene | SIRT1 | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | SIRT1 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | SIRT1 | C0020564 | Hypertrophy | 1 | CTD_human |
| Tgene | SIRT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | SIRT1 | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
| Tgene | SIRT1 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Tgene | SIRT1 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | SIRT1 | C0032285 | Pneumonia | 1 | CTD_human |
| Tgene | SIRT1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | SIRT1 | C0033937 | Psychoses, Drug | 1 | PSYGENET |
| Tgene | SIRT1 | C0035309 | Retinal Diseases | 1 | CTD_human |
| Tgene | SIRT1 | C0036421 | Systemic Scleroderma | 1 | CTD_human |
| Tgene | SIRT1 | C0036939 | Shared Paranoid Disorder | 1 | PSYGENET |
| Tgene | SIRT1 | C0040053 | Thrombosis | 1 | CTD_human |
| Tgene | SIRT1 | C0043020 | Wallerian Degeneration | 1 | CTD_human |
| Tgene | SIRT1 | C0085762 | Alcohol abuse | 1 | PSYGENET |
| Tgene | SIRT1 | C0155862 | Streptococcal pneumonia | 1 | CTD_human |
| Tgene | SIRT1 | C0271650 | Impaired glucose tolerance | 1 | CTD_human |
| Tgene | SIRT1 | C0273115 | Lung Injury | 1 | CTD_human |
| Tgene | SIRT1 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Tgene | SIRT1 | C0522224 | Paralysed | 1 | CTD_human |
| Tgene | SIRT1 | C0524620 | Metabolic Syndrome X | 1 | CTD_human |
| Tgene | SIRT1 | C0751955 | Brain Infarction | 1 | CTD_human |
| Tgene | SIRT1 | C0919532 | Genomic Instability | 1 | CTD_human |
| Tgene | SIRT1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | SIRT1 | C2609414 | Acute kidney injury | 1 | CTD_human |
| Tgene | SIRT1 | C2931673 | Ceroid lipofuscinosis, neuronal 1, infantile | 1 | CTD_human |
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