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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9098

FusionGeneSummary for CYB5B_SSPN

check button Fusion gene summary
Fusion gene informationFusion gene name: CYB5B_SSPN
Fusion gene ID: 9098
HgeneTgene
Gene symbol

CYB5B

SSPN

Gene ID

80777

8082

Gene namecytochrome b5 type Bsarcospan
SynonymsCYB5-M|CYPB5M|OMB5DAGA5|KRAG|NSPN|SPN1|SPN2
Cytomap

16q22.1

12p12.1

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b5 type Bcytochrome b5 outer mitochondrial membrane isoformcytochrome b5 type B (outer mitochondrial membrane)outer mitochondrial membrane cytochrome b5type 2 cyt-b5sarcospanK-ras oncogene-associated proteinKras oncogene-associatedkirsten-ras-associated proteinmicrospannanospansarcospan (Kras oncogene-associated gene)
Modification date2018052220180519
UniProtAcc

O43169

Q14714

Ensembl transtripts involved in fusion geneENST00000512062, ENST00000307892, 
ENST00000515314, ENST00000561792, 
ENST00000540266, ENST00000539019, 
ENST00000422622, ENST00000242729, 
ENST00000535504, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 3=27
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CYB5B [Title/Abstract] AND SSPN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-CD-8524-01ACYB5Bchr16

69458760

+SSPNchr12

26405801

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000512062ENST00000540266CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000512062ENST00000539019CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000512062ENST00000422622CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000512062ENST00000242729CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000512062ENST00000535504CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000307892ENST00000540266CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000307892ENST00000539019CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000307892ENST00000422622CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000307892ENST00000242729CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000307892ENST00000535504CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000515314ENST00000540266CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000515314ENST00000539019CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000515314ENST00000422622CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000515314ENST00000242729CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000515314ENST00000535504CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000561792ENST00000540266CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000561792ENST00000539019CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000561792ENST00000422622CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000561792ENST00000242729CYB5Bchr16

69458760

+SSPNchr12

26405801

+
5CDS-intronENST00000561792ENST00000535504CYB5Bchr16

69458760

+SSPNchr12

26405801

+

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FusionProtFeatures for CYB5B_SSPN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYB5B

O43169

SSPN

Q14714

Cytochrome b5 is a membrane bound hemoprotein whichfunction as an electron carrier for several membrane boundoxygenases. {ECO:0000250}. Component of the dystrophin-glycoprotein complex (DGC),a complex that spans the muscle plasma membrane and forms a linkbetween the F-actin cytoskeleton and the extracellular matrix.Preferentially associates with the sarcoglycan subcomplex of theDGC.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYB5B_SSPN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYB5B_SSPN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYB5BUCHL5, ELAVL1, APP, MRPL42, CORO1C, CLN8, ENO1, MOV10, NXF1, CCDC47, CCT2, ATP1A1, ATP1B3, CSE1L, HNRNPA1, HNRNPA3, CYB5R1, CYB5R3, CYCS, ISYNA1, PHB2, SEC31A, STOML2, TSR1, UQCRFS1, VARS, TCTN3, TMEM216, CREB3, COQ9, MCCC2, NDUFA4, C15orf48, DUSP22, DUSP9, COX15, LMNASSPN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYB5B_SSPN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CYB5B_SSPN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource