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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9094

FusionGeneSummary for CYB5A_RPL10

check button Fusion gene summary
Fusion gene informationFusion gene name: CYB5A_RPL10
Fusion gene ID: 9094
HgeneTgene
Gene symbol

CYB5A

RPL10

Gene ID

1528

6134

Gene namecytochrome b5 type Aribosomal protein L10
SynonymsCYB5|MCB5|METAGAUTSX5|DXS648|DXS648E|L10|MRXS35|NOV|QM
Cytomap

18q22.3

Xq28

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b5cytochrome b5 type A (microsomal)type 1 cyt-b560S ribosomal protein L10Wilms tumor-related proteinlaminin receptor homologlarge ribosomal subunit protein uL16tumor suppressor QM
Modification date2018051920180523
UniProtAcc

P00167

P27635

Ensembl transtripts involved in fusion geneENST00000340533, ENST00000494131, 
ENST00000397914, ENST00000299438, 
ENST00000579064, 
ENST00000369817, 
ENST00000479366, ENST00000424325, 
ENST00000406022, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 1=4
# samples 43
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/4*10)=2.90689059560852
Context

PubMed: CYB5A [Title/Abstract] AND RPL10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB162793CYB5Achr18

71920789

-RPL10chrX

153630762

-
ChiTaRS3.1CB164490CYB5Achr18

71920789

-RPL10chrX

153630762

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000340533ENST00000369817CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000340533ENST00000479366CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000340533ENST00000424325CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000340533ENST00000406022CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000494131ENST00000369817CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000494131ENST00000479366CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000494131ENST00000424325CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000494131ENST00000406022CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000397914ENST00000369817CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000397914ENST00000479366CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000397914ENST00000424325CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000397914ENST00000406022CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000299438ENST00000369817CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000299438ENST00000479366CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000299438ENST00000424325CYB5Achr18

71920789

-RPL10chrX

153630762

-
intron-intronENST00000299438ENST00000406022CYB5Achr18

71920789

-RPL10chrX

153630762

-
5CDS-intronENST00000579064ENST00000369817CYB5Achr18

71920789

-RPL10chrX

153630762

-
5CDS-intronENST00000579064ENST00000479366CYB5Achr18

71920789

-RPL10chrX

153630762

-
5CDS-intronENST00000579064ENST00000424325CYB5Achr18

71920789

-RPL10chrX

153630762

-
5CDS-intronENST00000579064ENST00000406022CYB5Achr18

71920789

-RPL10chrX

153630762

-

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FusionProtFeatures for CYB5A_RPL10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYB5A

P00167

RPL10

P27635

Cytochrome b5 is a membrane bound hemoprotein whichfunction as an electron carrier for several membrane boundoxygenases. Component of the large ribosomal subunit(PubMed:26290468). Plays a role in the formation of activelytranslating ribosomes (PubMed:26290468). May play a role in theembryonic brain development (PubMed:25316788).{ECO:0000269|PubMed:25316788, ECO:0000269|PubMed:26290468,ECO:0000305|PubMed:12962325}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CYB5A_RPL10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYB5A_RPL10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CYB5A_RPL10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRPL10P27635DB11638Artenimol60S ribosomal protein L10 {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for CYB5A_RPL10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCYB5AC0014175Endometriosis1CTD_human
HgeneCYB5AC0028754Obesity1CTD_human
HgeneCYB5AC0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneRPL10C3275438AUTISM, SUSCEPTIBILITY TO, X-LINKED 52UNIPROT
TgeneRPL10C0004352Autistic Disorder1CTD_human
TgeneRPL10C0033578Prostatic Neoplasms1CTD_human
TgeneRPL10C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human