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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 909

FusionGeneSummary for ADK_RPP38

check button Fusion gene summary
Fusion gene informationFusion gene name: ADK_RPP38
Fusion gene ID: 909
HgeneTgene
Gene symbol

ADK

RPP38

Gene ID

132

10557

Gene nameadenosine kinaseribonuclease P/MRP subunit p38
SynonymsAK-
Cytomap

10q22.2|10q11-q24

10p13

Type of geneprotein-codingprotein-coding
Descriptionadenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14ribonuclease P protein subunit p38RNaseP protein p38ribonuclease P/MRP 38kDa subunit
Modification date2018052320180522
UniProtAcc

P55263

P78345

Ensembl transtripts involved in fusion geneENST00000539909, ENST00000286621, 
ENST00000372734, ENST00000541550, 
ENST00000467840, 
ENST00000451677, 
ENST00000378202, ENST00000378197, 
Fusion gene scores* DoF score13 X 8 X 8=8321 X 1 X 1=1
# samples 161
** MAII scorelog2(16/832*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ADK [Title/Abstract] AND RPP38 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A1AI-01AADKchr10

75936644

+RPP38chr10

15153685

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000539909ENST00000451677ADKchr10

75936644

+RPP38chr10

15153685

+
intron-intronENST00000539909ENST00000378202ADKchr10

75936644

+RPP38chr10

15153685

+
intron-intronENST00000539909ENST00000378197ADKchr10

75936644

+RPP38chr10

15153685

+
intron-3UTRENST00000286621ENST00000451677ADKchr10

75936644

+RPP38chr10

15153685

+
intron-intronENST00000286621ENST00000378202ADKchr10

75936644

+RPP38chr10

15153685

+
intron-intronENST00000286621ENST00000378197ADKchr10

75936644

+RPP38chr10

15153685

+
5CDS-3UTRENST00000372734ENST00000451677ADKchr10

75936644

+RPP38chr10

15153685

+
5CDS-intronENST00000372734ENST00000378202ADKchr10

75936644

+RPP38chr10

15153685

+
5CDS-intronENST00000372734ENST00000378197ADKchr10

75936644

+RPP38chr10

15153685

+
5CDS-3UTRENST00000541550ENST00000451677ADKchr10

75936644

+RPP38chr10

15153685

+
5CDS-intronENST00000541550ENST00000378202ADKchr10

75936644

+RPP38chr10

15153685

+
5CDS-intronENST00000541550ENST00000378197ADKchr10

75936644

+RPP38chr10

15153685

+
intron-3UTRENST00000467840ENST00000451677ADKchr10

75936644

+RPP38chr10

15153685

+
intron-intronENST00000467840ENST00000378202ADKchr10

75936644

+RPP38chr10

15153685

+
intron-intronENST00000467840ENST00000378197ADKchr10

75936644

+RPP38chr10

15153685

+

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FusionProtFeatures for ADK_RPP38


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADK

P55263

RPP38

P78345

Component of ribonuclease P, a protein complex thatgenerates mature tRNA molecules by cleaving their 5'-ends. RPP38may associate transiently with RNase P RNA as a factor involved inthe transport of H1 RNA to the putative site of its assembly inthe cell, the nucleolus.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADK_RPP38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADK_RPP38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADKFICD, SRD5A3, ASS1, CAPG, DAZAP1, KYNU, LDHA, PIR, PTGR1, SOD1, NNMT, NQO1, PCBP1, PITPNB, RBM12, NPLOC4, FGBRPP38POP1, POP4, POP7, HDGF, CAST, PSMA1, PSMA4, PSMA5, PSMB1, PSMB4, PSMB5, PSMB8, AKAP2, CDKN2A, PSMA6, VASP, NPM1, SPACA1, PCGF6, RBM4B, VSIG4, CBWD1, SIAE, CASQ2, RPP25, CEP164, HNRNPU, NR2C2, CDC23, CTR9, NCSTN, ING4, ATL2, PAPD5, ASPM, C3orf17, RPP30, RPP21, C18orf21, RBM4, C1orf85, TOR1AIP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADK_RPP38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADKP55263DB00811RibavirinAdenosine kinasesmall moleculeapproved

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RelatedDiseases for ADK_RPP38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADKC0036341Schizophrenia1PSYGENET
HgeneADKC0242184Hypoxia1CTD_human
HgeneADKC3280381HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY1CTD_human;ORPHANET;UNIPROT
HgeneADKC3714756Intellectual Disability1CTD_human
TgeneRPP38C0025202melanoma1CTD_human