FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 9083

FusionGeneSummary for CYB561_AMZ2P1

check button Fusion gene summary
Fusion gene informationFusion gene name: CYB561_AMZ2P1
Fusion gene ID: 9083
HgeneTgene
Gene symbol

CYB561

AMZ2P1

Gene ID

1534

201283

Gene namecytochrome b561archaelysin family metallopeptidase 2 pseudogene 1
SynonymsCYB561A1|FRRS2-
Cytomap

17q23.3

17q24.1

Type of geneprotein-codingpseudo
Descriptioncytochrome b561cytochrome b-561cytochrome b561 family, member A1ferric-chelate reductase 2putative archaemetzincin-2-like protein
Modification date2018052320180519
UniProtAcc

P49447

Ensembl transtripts involved in fusion geneENST00000392975, ENST00000360793, 
ENST00000584031, ENST00000392976, 
ENST00000582297, ENST00000581573, 
ENST00000448884, ENST00000582034, 
ENST00000542042, ENST00000581163, 
ENST00000582997, 
ENST00000430983, 
Fusion gene scores* DoF score10 X 6 X 5=3002 X 2 X 2=8
# samples 112
** MAII scorelog2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: CYB561 [Title/Abstract] AND AMZ2P1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-77-7140-01ACYB561chr17

61523606

-AMZ2P1chr17

62964499

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000392975ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
5UTR-5UTRENST00000360793ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
intron-5UTRENST00000584031ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
intron-5UTRENST00000392976ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
5UTR-5UTRENST00000582297ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
intron-5UTRENST00000581573ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
5UTR-5UTRENST00000448884ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
5UTR-5UTRENST00000582034ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
intron-5UTRENST00000542042ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
intron-5UTRENST00000581163ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-
intron-5UTRENST00000582997ENST00000430983CYB561chr17

61523606

-AMZ2P1chr17

62964499

-

Top

FusionProtFeatures for CYB561_AMZ2P1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYB561

P49447

AMZ2P1

Secretory vesicle-specific electron transport protein. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CYB561_AMZ2P1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CYB561_AMZ2P1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CYB561EDA, RNF5, CREB3, PTPRA, TRIM25, LMNAAMZ2P1LIG4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CYB561_AMZ2P1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CYB561_AMZ2P1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource