	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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Fusion gene ID: 9076

FusionGeneSummary for CYB561D1_CYB561D1

Fusion gene summary

Fusion gene information	Fusion gene name: CYB561D1_CYB561D1
	Fusion gene ID: 9076
		Hgene	Tgene
	Gene symbol	CYB561D1	CYB561D1
	Gene ID	284613	284613
	Gene name	cytochrome b561 family member D1	cytochrome b561 family member D1
	Synonyms	-	-
	Cytomap	1p13.3	1p13.3
	Type of gene	protein-coding	protein-coding
	Description	cytochrome b561 domain-containing protein 1cytochrome b-561 domain containing 1	cytochrome b561 domain-containing protein 1cytochrome b-561 domain containing 1
	Modification date	20180330	20180330
	UniProtAcc	Q8N8Q1	Q8N8Q1
	Ensembl transtripts involved in fusion gene	ENST00000393709, ENST00000496961, ENST00000533024, ENST00000310611, ENST00000527072, ENST00000420578, ENST00000528785, ENST00000369868, ENST00000430195,	ENST00000393709, ENST00000496961, ENST00000533024, ENST00000310611, ENST00000527072, ENST00000420578, ENST00000528785, ENST00000369868, ENST00000430195,
Fusion gene scores	* DoF score	2 X 2 X 2=8	3 X 3 X 2=18
	# samples	2	3
	** MAII score	log2(2/8*10)=1.32192809488736	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CYB561D1 [Title/Abstract] AND CYB561D1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			CV376024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000393709	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000393709	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000393709	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000393709	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000393709	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000393709	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000393709	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000393709	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000393709	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000496961	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000496961	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000496961	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000496961	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000496961	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000496961	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000496961	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000496961	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000496961	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000533024	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000533024	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000533024	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000533024	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000533024	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000533024	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000533024	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000533024	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000533024	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000310611	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000310611	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000310611	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000310611	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000310611	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000310611	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000310611	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000310611	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000310611	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000527072	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000527072	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000527072	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000527072	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000527072	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000527072	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000527072	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000527072	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000527072	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000420578	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000420578	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000420578	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000420578	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000420578	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000420578	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000420578	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000420578	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000420578	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000528785	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000528785	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000528785	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000528785	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000528785	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000528785	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000528785	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000528785	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000528785	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000369868	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000369868	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000369868	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000369868	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000369868	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000369868	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000369868	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-intron	ENST00000369868	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
intron-3UTR	ENST00000369868	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000430195	ENST00000393709	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000430195	ENST00000496961	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000430195	ENST00000533024	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000430195	ENST00000310611	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000430195	ENST00000527072	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000430195	ENST00000420578	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000430195	ENST00000528785	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-intron	ENST00000430195	ENST00000369868	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+
3UTR-3UTR	ENST00000430195	ENST00000430195	CYB561D1	chr1	110041355	+	CYB561D1	chr1	110040942	+

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FusionProtFeatures for CYB561D1_CYB561D1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CYB561D1 Q8N8Q1	CYB561D1 Q8N8Q1

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CYB561D1_CYB561D1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CYB561D1_CYB561D1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CYB561D1_CYB561D1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CYB561D1_CYB561D1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 9076

FusionGeneSummary for CYB561D1_CYB561D1

FusionProtFeatures for CYB561D1_CYB561D1

FusionGeneSequence for CYB561D1_CYB561D1

FusionGenePPI for CYB561D1_CYB561D1

RelatedDrugs for CYB561D1_CYB561D1

RelatedDiseases for CYB561D1_CYB561D1