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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9059

FusionGeneSummary for CXCL14_C7

check button Fusion gene summary
Fusion gene informationFusion gene name: CXCL14_C7
Fusion gene ID: 9059
HgeneTgene
Gene symbol

CXCL14

C7

Gene ID

9547

730

Gene nameC-X-C motif chemokine ligand 14complement C7
SynonymsBMAC|BRAK|KEC|KS1|MIP-2g|MIP2G|NJAC|SCYB14-
Cytomap

5q31.1

5p13.1

Type of geneprotein-codingprotein-coding
DescriptionC-X-C motif chemokine 14CXC chemokine in breast and kidneyMIP-2 gammabolekinebreast and kidneychemokine (C-X-C motif) ligand 14chemokine BRAKsmall inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK)small-inducible cytokine B14tumor-supprcomplement component C7complement component 7
Modification date2018051920180519
UniProtAcc

O95715

P10643

Ensembl transtripts involved in fusion geneENST00000337225, ENST00000512158, 
ENST00000313164, ENST00000494960, 
Fusion gene scores* DoF score5 X 4 X 3=6012 X 3 X 9=324
# samples 513
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/324*10)=-1.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CXCL14 [Title/Abstract] AND C7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-BQ-5884-01ACXCL14chr5

134906376

-C7chr5

40954982

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337225ENST00000313164CXCL14chr5

134906376

-C7chr5

40954982

+
5CDS-intronENST00000337225ENST00000494960CXCL14chr5

134906376

-C7chr5

40954982

+
5CDS-intronENST00000512158ENST00000313164CXCL14chr5

134906376

-C7chr5

40954982

+
5CDS-intronENST00000512158ENST00000494960CXCL14chr5

134906376

-C7chr5

40954982

+

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FusionProtFeatures for CXCL14_C7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CXCL14

O95715

C7

P10643

Potent chemoattractant for neutrophils, and weaker fordendritic cells. Not chemotactic for T-cells, B-cells, monocytes,natural killer cells or granulocytes. Does not inhibitproliferation of myeloid progenitors in colony formation assays.{ECO:0000269|PubMed:10049774, ECO:0000269|PubMed:10946286}. Constituent of the membrane attack complex (MAC) thatplays a key role in the innate and adaptive immune response byforming pores in the plasma membrane of target cells. C7 serves asa membrane anchor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CXCL14_C7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CXCL14_C7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CXCL14APP, REL, TRIM23, TEX11, DLD, LMNAC7C5, CLU, PLG, NTRK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CXCL14_C7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CXCL14_C7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCXCL14C0004096Asthma1CTD_human
HgeneCXCL14C0011616Contact Dermatitis1CTD_human
HgeneCXCL14C0014175Endometriosis1CTD_human
HgeneCXCL14C0024121Lung Neoplasms1CTD_human
HgeneCXCL14C0236969Substance-Related Disorders1CTD_human
TgeneC7C1864694Complement Component 7 Deficiency3CTD_human;UNIPROT
TgeneC7C0023893Liver Cirrhosis, Experimental1CTD_human