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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9057

FusionGeneSummary for CXCL12_NKAIN3

check button Fusion gene summary
Fusion gene informationFusion gene name: CXCL12_NKAIN3
Fusion gene ID: 9057
HgeneTgene
Gene symbol

CXCL12

NKAIN3

Gene ID

6387

286183

Gene nameC-X-C motif chemokine ligand 12sodium/potassium transporting ATPase interacting 3
SynonymsIRH|PBSF|SCYB12|SDF1|TLSF|TPAR1FAM77D
Cytomap

10q11.21

8q12.3

Type of geneprotein-codingprotein-coding
Descriptionstromal cell-derived factor 1chemokine (C-X-C motif) ligand 12intercrine reduced in hepatomaspre-B cell growth-stimulating factorsodium/potassium-transporting ATPase subunit beta-1-interacting protein 3Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3Na+/K+ transporting ATPase interacting 3family with sequence similarity 77, member D
Modification date2018052720180523
UniProtAcc

P48061

Q8N8D7

Ensembl transtripts involved in fusion geneENST00000395795, ENST00000374429, 
ENST00000395793, ENST00000374426, 
ENST00000343575, ENST00000395794, 
ENST00000496375, 
ENST00000519049, 
ENST00000523211, ENST00000328472, 
Fusion gene scores* DoF score2 X 2 X 1=48 X 4 X 4=128
# samples 28
** MAII scorelog2(2/4*10)=2.32192809488736log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CXCL12 [Title/Abstract] AND NKAIN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCXCL12

GO:0033622

integrin activation

29301984

HgeneCXCL12

GO:0045785

positive regulation of cell adhesion

23620790

HgeneCXCL12

GO:0060326

cell chemotaxis

18308860

HgeneCXCL12

GO:0070098

chemokine-mediated signaling pathway

20388803

HgeneCXCL12

GO:0090026

positive regulation of monocyte chemotaxis

18802065

HgeneCXCL12

GO:1902230

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

20388803

HgeneCXCL12

GO:1903237

negative regulation of leukocyte tethering or rolling

18308860

HgeneCXCL12

GO:2000406

positive regulation of T cell migration

23620790

HgeneCXCL12

GO:2000669

negative regulation of dendritic cell apoptotic process

15059845


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DQ345518CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000395795ENST00000519049CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000395795ENST00000523211CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000395795ENST00000328472CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000374429ENST00000519049CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000374429ENST00000523211CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000374429ENST00000328472CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000395793ENST00000519049CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000395793ENST00000523211CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000395793ENST00000328472CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
5CDS-intronENST00000374426ENST00000519049CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
5CDS-intronENST00000374426ENST00000523211CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
5CDS-intronENST00000374426ENST00000328472CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000343575ENST00000519049CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000343575ENST00000523211CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000343575ENST00000328472CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000395794ENST00000519049CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000395794ENST00000523211CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000395794ENST00000328472CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000496375ENST00000519049CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000496375ENST00000523211CXCL12chr10

44871315

-NKAIN3chr8

63775881

-
intron-intronENST00000496375ENST00000328472CXCL12chr10

44871315

-NKAIN3chr8

63775881

-

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FusionProtFeatures for CXCL12_NKAIN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CXCL12

P48061

NKAIN3

Q8N8D7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CXCL12_NKAIN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CXCL12_NKAIN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CXCL12_NKAIN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCXCL12P48061DB06822TinzaparinStromal cell-derived factor 1small moleculeapproved

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RelatedDiseases for CXCL12_NKAIN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCXCL12C0027626Neoplasm Invasiveness3CTD_human
HgeneCXCL12C0027627Neoplasm Metastasis2CTD_human
HgeneCXCL12C0022116Ischemia1CTD_human
HgeneCXCL12C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCXCL12C0033578Prostatic Neoplasms1CTD_human
HgeneCXCL12C0266929Chronic Periodontitis1CTD_human
HgeneCXCL12C0345967Malignant mesothelioma1CTD_human
HgeneCXCL12C1458155Mammary Neoplasms1CTD_human
HgeneCXCL12C1956346Coronary Artery Disease1CTD_human
HgeneCXCL12C2239176Liver carcinoma1CTD_human