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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9052

FusionGeneSummary for CXADR_CXADR

check button Fusion gene summary
Fusion gene informationFusion gene name: CXADR_CXADR
Fusion gene ID: 9052
HgeneTgene
Gene symbol

CXADR

CXADR

Gene ID

1525

1525

Gene nameCXADR, Ig-like cell adhesion moleculeCXADR, Ig-like cell adhesion molecule
SynonymsCAR|CAR4/6|HCARCAR|CAR4/6|HCAR
Cytomap

21q21.1

21q21.1

Type of geneprotein-codingprotein-coding
Descriptioncoxsackievirus and adenovirus receptor46 kD coxsackievirus and adenovirus receptor (CAR) proteinCVB3-binding proteinHCVADRcoxsackie virus and adenovirus receptorcoxsackievirus B-adenovirus receptorcoxsackievirus and adenovirus receptor46 kD coxsackievirus and adenovirus receptor (CAR) proteinCVB3-binding proteinHCVADRcoxsackie virus and adenovirus receptorcoxsackievirus B-adenovirus receptor
Modification date2018051920180519
UniProtAcc

P78310

P78310

Ensembl transtripts involved in fusion geneENST00000284878, ENST00000400166, 
ENST00000356275, ENST00000400165, 
ENST00000306618, ENST00000400169, 
ENST00000284878, ENST00000400166, 
ENST00000356275, ENST00000400165, 
ENST00000306618, ENST00000400169, 
Fusion gene scores* DoF score6 X 3 X 4=723 X 3 X 2=18
# samples 53
** MAII scorelog2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CXADR [Title/Abstract] AND CXADR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCXADR

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

12869515|15800062

HgeneCXADR

GO:0031532

actin cytoskeleton reorganization

17675666

TgeneCXADR

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

12869515|15800062

TgeneCXADR

GO:0031532

actin cytoskeleton reorganization

17675666


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB162053CXADRchr21

18888385

-CXADRchr21

18888635

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000284878ENST00000284878CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000284878ENST00000400166CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000284878ENST00000356275CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000284878ENST00000400165CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000284878ENST00000306618CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000284878ENST00000400169CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400166ENST00000284878CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400166ENST00000400166CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400166ENST00000356275CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400166ENST00000400165CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400166ENST00000306618CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400166ENST00000400169CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000356275ENST00000284878CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000356275ENST00000400166CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000356275ENST00000356275CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000356275ENST00000400165CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000356275ENST00000306618CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000356275ENST00000400169CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400165ENST00000284878CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400165ENST00000400166CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400165ENST00000356275CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400165ENST00000400165CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400165ENST00000306618CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400165ENST00000400169CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000306618ENST00000284878CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000306618ENST00000400166CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000306618ENST00000356275CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000306618ENST00000400165CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000306618ENST00000306618CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000306618ENST00000400169CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400169ENST00000284878CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400169ENST00000400166CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400169ENST00000356275CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400169ENST00000400165CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400169ENST00000306618CXADRchr21

18888385

-CXADRchr21

18888635

+
intron-intronENST00000400169ENST00000400169CXADRchr21

18888385

-CXADRchr21

18888635

+

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FusionProtFeatures for CXADR_CXADR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CXADR

P78310

CXADR

P78310


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CXADR_CXADR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CXADR_CXADR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CXADR_CXADR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CXADR_CXADR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCXADRC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCXADRC0023893Liver Cirrhosis, Experimental1CTD_human