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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 90

FusionGeneSummary for ABCA13_C22orf34

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCA13_C22orf34
Fusion gene ID: 90
HgeneTgene
Gene symbol

ABCA13

C22orf34

Gene ID

154664

348645

Gene nameATP binding cassette subfamily A member 13chromosome 22 open reading frame 34
Synonyms--
Cytomap

7p12.3

22q13.33

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family A member 13ATP binding cassette transporter A13ATP-binding cassette sub-family A member 13 variant 2ATP-binding cassette sub-family A member 13 variant 3ATP-binding cassette, sub-family A (ABC1), member 13uncharacterized protein C22orf34
Modification date2018052320180329
UniProtAcc

Q86UQ4

Q6ZV56

Ensembl transtripts involved in fusion geneENST00000435803, ENST00000544596, 
ENST00000498829, ENST00000400023, 
ENST00000405854, ENST00000444628, 
Fusion gene scores* DoF score5 X 5 X 2=502 X 2 X 1=4
# samples 52
** MAII scorelog2(5/50*10)=0log2(2/4*10)=2.32192809488736
Context

PubMed: ABCA13 [Title/Abstract] AND C22orf34 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF899276ABCA13chr7

48326933

-C22orf34chr22

50035231

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000435803ENST00000498829ABCA13chr7

48326933

-C22orf34chr22

50035231

+
intron-intronENST00000435803ENST00000400023ABCA13chr7

48326933

-C22orf34chr22

50035231

+
intron-intronENST00000435803ENST00000405854ABCA13chr7

48326933

-C22orf34chr22

50035231

+
intron-intronENST00000435803ENST00000444628ABCA13chr7

48326933

-C22orf34chr22

50035231

+
intron-intronENST00000544596ENST00000498829ABCA13chr7

48326933

-C22orf34chr22

50035231

+
intron-intronENST00000544596ENST00000400023ABCA13chr7

48326933

-C22orf34chr22

50035231

+
intron-intronENST00000544596ENST00000405854ABCA13chr7

48326933

-C22orf34chr22

50035231

+
intron-intronENST00000544596ENST00000444628ABCA13chr7

48326933

-C22orf34chr22

50035231

+

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FusionProtFeatures for ABCA13_C22orf34


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCA13

Q86UQ4

C22orf34

Q6ZV56


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABCA13_C22orf34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABCA13_C22orf34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABCA13_C22orf34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABCA13_C22orf34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCA13C0005586Bipolar Disorder1PSYGENET
HgeneABCA13C0009404Colorectal Neoplasms1CTD_human
HgeneABCA13C0036341Schizophrenia1PSYGENET