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Fusion gene ID: 8993 |
FusionGeneSummary for CUL4A_TMEM255B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CUL4A_TMEM255B | Fusion gene ID: 8993 | Hgene | Tgene | Gene symbol | CUL4A | TMEM255B | Gene ID | 8451 | 348013 |
| Gene name | cullin 4A | transmembrane protein 255B | |
| Synonyms | - | FAM70B | |
| Cytomap | 13q34 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cullin-4ACUL-4A | transmembrane protein 255Bfamily with sequence similarity 70, member Bprotein FAM70B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q13619 | Q8WV15 | |
| Ensembl transtripts involved in fusion gene | ENST00000375441, ENST00000451881, ENST00000326335, ENST00000375440, ENST00000463426, | ENST00000375353, ENST00000467169, | |
| Fusion gene scores | * DoF score | 7 X 10 X 9=630 | 2 X 2 X 2=8 |
| # samples | 13 | 2 | |
| ** MAII score | log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CUL4A [Title/Abstract] AND TMEM255B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-56-A4ZK-01A | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000375441 | ENST00000375353 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| 5CDS-intron | ENST00000375441 | ENST00000467169 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| Frame-shift | ENST00000451881 | ENST00000375353 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| 5CDS-intron | ENST00000451881 | ENST00000467169 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| Frame-shift | ENST00000326335 | ENST00000375353 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| 5CDS-intron | ENST00000326335 | ENST00000467169 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| Frame-shift | ENST00000375440 | ENST00000375353 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| 5CDS-intron | ENST00000375440 | ENST00000467169 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| intron-3CDS | ENST00000463426 | ENST00000375353 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
| intron-intron | ENST00000463426 | ENST00000467169 | CUL4A | chr13 | 113897359 | + | TMEM255B | chr13 | 114502312 | + |
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FusionProtFeatures for CUL4A_TMEM255B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CUL4A | TMEM255B |
| Core component of multiple cullin-RING-based E3ubiquitin-protein ligase complexes which mediate theubiquitination of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate andthe ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. The functionalspecificity of the E3 ubiquitin-protein ligase complex depends onthe variable substrate recognition component. DCX(DET1-COP1)directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination ofXPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required forefficient histone deposition during replication-coupled (H3.1) andreplication-independent (H3.3) nucleosome assembly, probably byfacilitating the transfer of H3 from ASF1A/ASF1B to otherchaperones involved in histone deposition. DCX(DTL) plays a rolein PCNA-dependent polyubiquitination of CDT1 and MDM2-dependentubiquitination of TP53 in response to radiation-induced DNA damageand during DNA replication. In association with DDB1 and SKP2probably is involved in ubiquitination of CDKN1B/p27kip. Isinvolved in ubiquitination of HOXA9. DCX(DTL) directsautoubiquitination of DTL. {ECO:0000269|PubMed:14578910,ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697,ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899,ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445,ECO:0000269|PubMed:24209620}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL4A_TMEM255B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL4A_TMEM255B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CUL4A | RNF7, DET1, RFWD2, CAND1, RBX1, HSPA1A, HSP90AA1, NEDD8, TUBA1B, CDKN1A, DDB1, DDB2, CUL4B, FBXW5, NF2, SAP130, CDKN1B, COPS5, COPS6, PTGS2, UBC, PCNA, TRPC4AP, DDA1, CRBN, COPS3, COPS4, COPS2, COPS8, COPS7B, COPS7A, DCAF11, DCAF5, BRWD1, PHIP, DCAF6, DCAF12, DCAF10, DCAF4, WDTC1, SKP2, TOR1AIP2, BANF1, EMD, DTL, WDR26, GRWD1, RBBP5, WDR5B, POC1B, SNRNP40, WDR61, WDR76, WDR82, WDR5, TLE2, EED, HIST1H3A, CDT1, CHEK1, COMMD1, DNMT3B, VPRBP, UBXN7, MYC, KAT2A, RASSF1, RAG1, SALL2, RAD21, HOXA9, HOXB4, GPS1, GLMN, MCM10, NACC1, CTNNB1, TP53, MDM2, CUL1, RBBP7, FBXW8, WSB1, WSB2, NUP43, BTRC, PWP1, RBBP4, ERCC8, CUL4A, DCUN1D1, AK9, DCST1, DCAF8, AMBRA1, DCAF12L2, DCAF16, CUL5, DCAF4L1, IGF2BP1, IGHV3OR15-7, MYEOV2, ANAPC5, CDY2B, CDY2A, OTULIN, LOC285556, NXPH3, RGS12, SCAF11, SH3RF2, SLA, TCHP, USP7, MAP4, ABCA10, XXYLT1, SYNM, ZNF407, ZNF525, CSRP2BP, RPL26, SLC25A22, SFXN1, HSPA8, TFG, CUL3, KRT10, DCAF7, CA2, KLHL9, KRT1, TUBA4B, FUS, HSPA1B, KRT9, TUBB4B, HSP90B1, PSMC6, SKP1, TUBA4A, EWSR1, H2AFV, HAX1, HNRNPA2B1, HNRNPUL1, HSPA1L, IARS, KRT2, KRT24, PCBD1, SNRPD1, TUBA1C, TUBB1, HNRNPH1, HNRNPH3, HSPA5, LGALS3BP, NCL, PABPC1, PPP2R1A, SNRPA, SNRPB, CCT5, DNAJC10, EEF1A1, EEF1A2, ENO1, HNRNPAB, HNRNPF, HNRNPDL, HSPA7, HSPA9, KRT76, PRDX1, QPCT, RPL15, RPL7A, RPLP2, RPS2, SRSF3, SLC25A5, SLC25A6, SSBP1, TAF15, TUBB, BAG4, C1QBP, DDX21, DDX5, DHX15, DHX9, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, HNRNPD, HSP90AB1, HSPD1, KRT75, NFKB1, NPM1, PABPC4, RPL10A, RPL11, RPL19, RPL22, RPL23A, RPL38, RPL4, RPL7AP27, RPLP1, RPS14, RPS15A, RPS18, RPS20, RPS3, SDHA, SNRNP70, SNRPD3, SNRPE, TIA1, TIAL1, CSN1S1, MYB, LRWD1, ERCC6, UBE2E3, GRK5, SENP8, DCAF15, SUGT1, CHEK2, RPTOR, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, DDIT4, SF3B3, DICER1, DLC1, CAST, PRMT5, ASB4, HIST1H1C, DAB2IP, DCAF17, IP6K1, HIST1H1A, VCP, ARIH1, ABCE1, CLCN1, DCAF4L2, C9orf41, MRPS11, CCNG1, TUBG1, SAMHD1, UNK, MTM1, IFI16, CENPA, HIST1H2BG, PYGO2, GNB2, GNB1, GNB3, GNB4, GNB5, MCM2, DPPA4, NANOG, POU5F1, UVRAG, SLBP, FKBP8, IKZF3, ATP6V0D1, TMCO3, CRYBA4, TRIM16, TRIM25, LATS1, TWIST1, TES, SIRT7 | TMEM255B | WWP1, PHYHIP, PLXDC2, AMZ2, RHOU |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL4A_TMEM255B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL4A_TMEM255B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CUL4A | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
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