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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8990

FusionGeneSummary for CUL4A_SUPT16H

check button Fusion gene summary
Fusion gene informationFusion gene name: CUL4A_SUPT16H
Fusion gene ID: 8990
HgeneTgene
Gene symbol

CUL4A

SUPT16H

Gene ID

8451

11198

Gene namecullin 4ASPT16 homolog, facilitates chromatin remodeling subunit
Synonyms-CDC68|FACTP140|SPT16|SPT16/CDC68
Cytomap

13q34

14q11.2

Type of geneprotein-codingprotein-coding
Descriptioncullin-4ACUL-4AFACT complex subunit SPT16FACT 140 kDa subunitchromatin-specific transcription elongation factor 140 kDa subunitfacilitates chromatin remodeling 140 kDa subunitfacilitates chromatin transcription complex subunit SPT16hSPT16suppressor of Ty 16 homolo
Modification date2018052320180523
UniProtAcc

Q13619

Q9Y5B9

Ensembl transtripts involved in fusion geneENST00000375441, ENST00000451881, 
ENST00000326335, ENST00000375440, 
ENST00000463426, 
ENST00000216297, 
ENST00000555943, 
Fusion gene scores* DoF score7 X 10 X 9=63037 X 4 X 15=2220
# samples 1340
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(40/2220*10)=-2.47248777146274
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CUL4A [Title/Abstract] AND SUPT16H [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-55-8620-01ACUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000375441ENST00000216297CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
intron-intronENST00000375441ENST00000555943CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
5CDS-intronENST00000451881ENST00000216297CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
5CDS-intronENST00000451881ENST00000555943CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
3UTR-intronENST00000326335ENST00000216297CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
3UTR-intronENST00000326335ENST00000555943CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
intron-intronENST00000375440ENST00000216297CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
intron-intronENST00000375440ENST00000555943CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
intron-intronENST00000463426ENST00000216297CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-
intron-intronENST00000463426ENST00000555943CUL4Achr13

113919391

+SUPT16Hchr14

21829491

-

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FusionProtFeatures for CUL4A_SUPT16H


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUL4A

Q13619

SUPT16H

Q9Y5B9

Core component of multiple cullin-RING-based E3ubiquitin-protein ligase complexes which mediate theubiquitination of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate andthe ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. The functionalspecificity of the E3 ubiquitin-protein ligase complex depends onthe variable substrate recognition component. DCX(DET1-COP1)directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination ofXPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required forefficient histone deposition during replication-coupled (H3.1) andreplication-independent (H3.3) nucleosome assembly, probably byfacilitating the transfer of H3 from ASF1A/ASF1B to otherchaperones involved in histone deposition. DCX(DTL) plays a rolein PCNA-dependent polyubiquitination of CDT1 and MDM2-dependentubiquitination of TP53 in response to radiation-induced DNA damageand during DNA replication. In association with DDB1 and SKP2probably is involved in ubiquitination of CDKN1B/p27kip. Isinvolved in ubiquitination of HOXA9. DCX(DTL) directsautoubiquitination of DTL. {ECO:0000269|PubMed:14578910,ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697,ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899,ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445,ECO:0000269|PubMed:24209620}. Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure. It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of 'Ser-392' of p53/TP53 via its association withCK2 (casein kinase II). {ECO:0000269|PubMed:10912001,ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006,ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704,ECO:0000269|PubMed:9836642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CUL4A_SUPT16H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CUL4A_SUPT16H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CUL4ARNF7, DET1, RFWD2, CAND1, RBX1, HSPA1A, HSP90AA1, NEDD8, TUBA1B, CDKN1A, DDB1, DDB2, CUL4B, FBXW5, NF2, SAP130, CDKN1B, COPS5, COPS6, PTGS2, UBC, PCNA, TRPC4AP, DDA1, CRBN, COPS3, COPS4, COPS2, COPS8, COPS7B, COPS7A, DCAF11, DCAF5, BRWD1, PHIP, DCAF6, DCAF12, DCAF10, DCAF4, WDTC1, SKP2, TOR1AIP2, BANF1, EMD, DTL, WDR26, GRWD1, RBBP5, WDR5B, POC1B, SNRNP40, WDR61, WDR76, WDR82, WDR5, TLE2, EED, HIST1H3A, CDT1, CHEK1, COMMD1, DNMT3B, VPRBP, UBXN7, MYC, KAT2A, RASSF1, RAG1, SALL2, RAD21, HOXA9, HOXB4, GPS1, GLMN, MCM10, NACC1, CTNNB1, TP53, MDM2, CUL1, RBBP7, FBXW8, WSB1, WSB2, NUP43, BTRC, PWP1, RBBP4, ERCC8, CUL4A, DCUN1D1, AK9, DCST1, DCAF8, AMBRA1, DCAF12L2, DCAF16, CUL5, DCAF4L1, IGF2BP1, IGHV3OR15-7, MYEOV2, ANAPC5, CDY2B, CDY2A, OTULIN, LOC285556, NXPH3, RGS12, SCAF11, SH3RF2, SLA, TCHP, USP7, MAP4, ABCA10, XXYLT1, SYNM, ZNF407, ZNF525, CSRP2BP, RPL26, SLC25A22, SFXN1, HSPA8, TFG, CUL3, KRT10, DCAF7, CA2, KLHL9, KRT1, TUBA4B, FUS, HSPA1B, KRT9, TUBB4B, HSP90B1, PSMC6, SKP1, TUBA4A, EWSR1, H2AFV, HAX1, HNRNPA2B1, HNRNPUL1, HSPA1L, IARS, KRT2, KRT24, PCBD1, SNRPD1, TUBA1C, TUBB1, HNRNPH1, HNRNPH3, HSPA5, LGALS3BP, NCL, PABPC1, PPP2R1A, SNRPA, SNRPB, CCT5, DNAJC10, EEF1A1, EEF1A2, ENO1, HNRNPAB, HNRNPF, HNRNPDL, HSPA7, HSPA9, KRT76, PRDX1, QPCT, RPL15, RPL7A, RPLP2, RPS2, SRSF3, SLC25A5, SLC25A6, SSBP1, TAF15, TUBB, BAG4, C1QBP, DDX21, DDX5, DHX15, DHX9, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, HNRNPD, HSP90AB1, HSPD1, KRT75, NFKB1, NPM1, PABPC4, RPL10A, RPL11, RPL19, RPL22, RPL23A, RPL38, RPL4, RPL7AP27, RPLP1, RPS14, RPS15A, RPS18, RPS20, RPS3, SDHA, SNRNP70, SNRPD3, SNRPE, TIA1, TIAL1, CSN1S1, MYB, LRWD1, ERCC6, UBE2E3, GRK5, SENP8, DCAF15, SUGT1, CHEK2, RPTOR, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, DDIT4, SF3B3, DICER1, DLC1, CAST, PRMT5, ASB4, HIST1H1C, DAB2IP, DCAF17, IP6K1, HIST1H1A, VCP, ARIH1, ABCE1, CLCN1, DCAF4L2, C9orf41, MRPS11, CCNG1, TUBG1, SAMHD1, UNK, MTM1, IFI16, CENPA, HIST1H2BG, PYGO2, GNB2, GNB1, GNB3, GNB4, GNB5, MCM2, DPPA4, NANOG, POU5F1, UVRAG, SLBP, FKBP8, IKZF3, ATP6V0D1, TMCO3, CRYBA4, TRIM16, TRIM25, LATS1, TWIST1, TES, SIRT7SUPT16HBRCC3, PRKAA1, POLR1A, POLR1E, SSRP1, CHD1L, MCM4, PAF1, PARP1, H2AFX, MKL1, H3F3A, TRIM33, TAL1, CDK9, SUPT16H, MMS22L, TONSL, SMARCAD1, SREK1, SOX2, HDGF, ELAVL1, XRCC5, CUL3, CDK2, CAND1, FYTTD1, CSNK2A1, CSNK2B, SAP18, RTF1, LEO1, TOP1, DHX15, CTR9, IK, PRPF4B, SNRPD2, NCSTN, S100A9, HNRNPM, NHP2L1, DDX21, PRPF6, SF3A1, SNRPD1, PRPF3, ACIN1, EEF1A1, RBM25, MSH6, PRPF8, USP39, MSH2, PSIP1, CENPA, ESR1, FMNL1, VCP, PNKP, CD81, IGSF8, ICAM1, SRPK2, FTH1, QRICH1, RNF20, ATRX, HIST1H2AB, MOV10, NXF1, BRCA1, CUL7, OBSL1, EED, RNF2, BMI1, SUMO2, ABCE1, RPA4, SPIN2B, RPA2, SPIN1, TIPIN, RNF146, POLB, APLF, HIST1H2BA, MAFF, FBXW11, BRD3, CDK12, HMGB1, IWS1, NAP1L1, PES1, SRRM1, CDK11A, HMGB2, HMGB3, KRI1, TOP2B, ZC3H18, SFN, NTRK1, IFI16, MED4, EWSR1, CEP97, CNTROB, SPICE1, CEP164, DCTN1, POC1B, STIL, HIST1H3E, DAXX, HNRNPU, NPM1, RPL10, ETAA1, CENPQ, NF2, NANOG, UBR5, SBF1, HIST1H3A, MACROD1, H2AFY2, XPC, XRCC6, HIST1H4A, NAA40, WDR76, ALX3, TEAD2, L3MBTL1, CETN1, SIX2, POLL, RPA3, WRN, COX15, DLD, PDHA1, VDAC1, TRIM25, YAP1, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CUL4A_SUPT16H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CUL4A_SUPT16H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCUL4AC0038325Stevens-Johnson Syndrome1CTD_human