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Fusion gene ID: 8984 |
FusionGeneSummary for CUL3_PCMTD1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CUL3_PCMTD1 | Fusion gene ID: 8984 | Hgene | Tgene | Gene symbol | CUL3 | PCMTD1 | Gene ID | 8452 | 115294 |
| Gene name | cullin 3 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | |
| Synonyms | CUL-3|PHA2E | - | |
| Cytomap | 2q36.2 | 8q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cullin-3 | protein-L-isoaspartate O-methyltransferase domain-containing protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13618 | Q96MG8 | |
| Ensembl transtripts involved in fusion gene | ENST00000264414, ENST00000344951, ENST00000409096, ENST00000409777, ENST00000432260, | ENST00000360540, ENST00000544451, ENST00000519559, ENST00000522514, ENST00000521344, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 3 X 3=27 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/27*10)=0.888968687611256 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CUL3 [Title/Abstract] AND PCMTD1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CUL3 | GO:0000209 | protein polyubiquitination | 19261606 |
| Hgene | CUL3 | GO:0006511 | ubiquitin-dependent protein catabolic process | 25401743|27561354 |
| Hgene | CUL3 | GO:0006513 | protein monoubiquitination | 22358839 |
| Hgene | CUL3 | GO:0006888 | ER to Golgi vesicle-mediated transport | 22358839 |
| Hgene | CUL3 | GO:0016567 | protein ubiquitination | 17543862|19782033|19995937|20389280 |
| Hgene | CUL3 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 10500095 |
| Hgene | CUL3 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 19261606|19782033|20389280 |
| Hgene | CUL3 | GO:0071630 | nuclear protein quality control by the ubiquitin-proteasome system | 27561354 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1604-01A | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000264414 | ENST00000360540 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| 5CDS-intron | ENST00000264414 | ENST00000544451 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| 5CDS-5UTR | ENST00000264414 | ENST00000519559 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| 5CDS-5UTR | ENST00000264414 | ENST00000522514 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| 5CDS-intron | ENST00000264414 | ENST00000521344 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| Frame-shift | ENST00000344951 | ENST00000360540 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| 5CDS-intron | ENST00000344951 | ENST00000544451 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| 5CDS-5UTR | ENST00000344951 | ENST00000519559 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| 5CDS-5UTR | ENST00000344951 | ENST00000522514 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| 5CDS-intron | ENST00000344951 | ENST00000521344 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-3CDS | ENST00000409096 | ENST00000360540 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-intron | ENST00000409096 | ENST00000544451 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-5UTR | ENST00000409096 | ENST00000519559 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-5UTR | ENST00000409096 | ENST00000522514 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-intron | ENST00000409096 | ENST00000521344 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-3CDS | ENST00000409777 | ENST00000360540 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-intron | ENST00000409777 | ENST00000544451 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-5UTR | ENST00000409777 | ENST00000519559 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-5UTR | ENST00000409777 | ENST00000522514 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-intron | ENST00000409777 | ENST00000521344 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-3CDS | ENST00000432260 | ENST00000360540 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-intron | ENST00000432260 | ENST00000544451 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-5UTR | ENST00000432260 | ENST00000519559 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-5UTR | ENST00000432260 | ENST00000522514 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
| intron-intron | ENST00000432260 | ENST00000521344 | CUL3 | chr2 | 225449661 | - | PCMTD1 | chr8 | 52758323 | - |
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FusionProtFeatures for CUL3_PCMTD1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CUL3 | PCMTD1 |
| Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate theubiquitination and subsequent proteasomal degradation of targetproteins. BCR complexes and ARIH1 collaborate in tandem to mediateubiquitination of target proteins (PubMed:27565346). As a scaffoldprotein may contribute to catalysis through positioning of thesubstrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on theneddylation of the cullin subunit and is inhibited by theassociation of the deneddylated cullin subunit with TIP120A/CAND1.The functional specificity of the BCR complex depends on the BTBdomain-containing protein as the substrate recognition component.BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) isinvolved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX,GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimericSPOPL or the heterodimer formed by SPOP and SPOPL; these complexeshave lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controlsthe dynamic behavior of AURKB on mitotic chromosomes and therebycoordinates faithful mitotic progression and completion ofcytokinesis. BCR(KLHL12) is involved in ER-Golgi transport byregulating the size of COPII coats, thereby playing a key role incollagen export, which is required for embryonic stem (ES) cellsdivision: BCR(KLHL12) acts by mediating monoubiquitination ofSEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27716508).BCR(KLHL3) acts as a regulator of ion transport in the distalnephron; by mediating ubiquitination of WNK4 (PubMed:23387299,PubMed:23453970, PubMed:23576762). The BCR(KLHL20) E3 ubiquitinligase complex is involved in interferon response and anterogradeGolgi to endosome transport: it mediates both ubiquitinationleading to degradation and 'Lys-33'-linked ubiquitination(PubMed:20389280, PubMed:21840486, PubMed:21670212,PubMed:24768539). The BCR(KLHL21) E3 ubiquitin ligase complexregulates localization of the chromosomal passenger complex (CPC)from chromosomes to the spindle midzone in anaphase and mediatesthe ubiquitination of AURKB (PubMed:19995937). The BCR(KLHL22)ubiquitin ligase complex mediates monoubiquitination of PLK1,leading to PLK1 dissociation from phosphoreceptor proteins andsubsequent removal from kinetochores, allowing silencing of thespindle assembly checkpoint (SAC) and chromosome segregation(PubMed:23455478). The BCR(KLHL22) ubiquitin ligase complex isalso responsible for the amino acid-stimulated 'Lys-48'polyubiquitination and proteasomal degradation of DEPDC5. Throughthe degradation of DEPDC5, releases the GATOR1 complex-mediatedinhibition of the TORC1 pathway (PubMed:29769719). The BCR(KLHL25)ubiquitin ligase complex is involved in translational homeostasisby mediating ubiquitination and subsequent degradation ofhypophosphorylated EIF4EBP1 (4E-BP1) (PubMed:22578813). TheBCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1and TCOF1, leading to remodel the translational program ofdifferentiating cells in favor of neural crest specification(PubMed:26399832). Involved in ubiquitination of cyclin E and ofcyclin D1 (in vitro) thus involved in regulation of G1/Stransition. Involved in the ubiquitination of KEAP1, ENC1 andKLHL41. In concert with ATF2 and RBX1, promotes degradation ofKAT5 thereby attenuating its ability to acetylate and activateATM. The BCR(KCTD17) E3 ubiquitin ligase complex mediatesubiquitination and degradation of TCHP, a down-regulator of ciliumassembly, thereby inducing ciliogenesis (PubMed:25270598). TheBCR(KLHL24) E3 ubiquitin ligase complex mediates ubiquitination ofKRT14, controls KRT14 levels during keratinocytes differentiation,and is essential for skin integrity (PubMed:27798626).{ECO:0000269|PubMed:10500095, ECO:0000269|PubMed:11311237,ECO:0000269|PubMed:15897469, ECO:0000269|PubMed:15983046,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:17543862,ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:19261606,ECO:0000269|PubMed:19995937, ECO:0000269|PubMed:20389280,ECO:0000269|PubMed:21670212, ECO:0000269|PubMed:21840486,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22358839,ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:22632832,ECO:0000269|PubMed:23387299, ECO:0000269|PubMed:23453970,ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:23576762,ECO:0000269|PubMed:24768539, ECO:0000269|PubMed:25270598,ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:27565346,ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27798626,ECO:0000269|PubMed:29769719}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL3_PCMTD1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL3_PCMTD1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CUL3 | CCNE1, CAND1, RBX1, DCUN1D1, KCTD5, ABTB2, DNTT, KEAP1, KLHL12, COPS5, COPS6, CUL3, PMS1, PGAM5, KCTD11, GABARAPL1, GABARAPL2, KBTBD7, COPS3, GAN, ENC1, KLHL41, NFE2L2, BMI1, H2AFY, KLHL20, DAPK1, ARHGEF12, COMMD1, DNMT3B, SPOP, IKBKB, KLHL42, PDIA2, KATNA1, RHOA, KLHL21, KLHL9, KLHL13, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, HSF2, SQSTM1, NCOA3, KBTBD13, KAT5, ATF2, GLMN, KLHL25, NACC1, PSMA7, COPS2, NEDD8, HTR7, TNFAIP1, RHOBTB2, HSPA4, HSPD1, KCTD7, AURKB, KLHL22, BTBD2, BTBD1, KLHL7, IPP, KBTBD2, IBTK, KCTD9, KLHL17, DYNC1I2, KLHL5, ZSWIM8, RHOBTB3, KLHL36, KLHL11, BTBD10, CDKN2AIP, DYNLRB1, KCTD2, KCTD20, KLHL28, KLHL4, LRRC42, RPAP3, KLHL26, KBTBD4, KBTBD6, DYNC1I1, GMCL1, KIAA0020, KLHL2, KPNA5, MLLT6, OFCC1, PGM3, KBTBD8, NISCH, KCTD18, KCTD6, ARMC5, CSDE1, DHX38, SLC1A3, CPOX, TEFM, NUDCD3, KLHL18, KLHL23, SHKBP1, PLEC, COPS4, ABCA13, AKAP11, CAPRIN1, HOOK3, PIK3R2, ANKRD39, PHF6, PLRG1, ELAVL2, KCTD3, KLHL24, HNRNPU, ALDH2, BCKDHA, DNAJC13, GPS1, KRT84, LARP4B, KLHL15, HCFC1, RHOBTB1, ATXN2L, FBXL17, GLUD1, IMPDH2, KDELC1, MRPL19, MRPS11, RPL10, SF3A1, COPS7A, PRRC2A, DLG4, PAIP1, RPS27, DYNC1H1, ARF4, EMC1, PRPF40A, RPA3, RPS28, ATXN2, ITCH, KCTD10, LAS1L, SUPT5H, KLHL8, MLLT11, COPS7B, AGO3, FUBP1, GEMIN5, GPATCH4, SEC16A, MRPS31, DUT, PYCR2, WDR6, NUP62, BTBD9, CTTN, KPNA1, PRKAR1A, SAFB, COPS8, LLGL1, SART1, DCTN1, NDUFS2, RPSAP55, SRPX, SEC31A, AKAP8L, SART3, NUP88, CTNND1, DCTN2, DYNC1LI1, IGHV3OR15-7, SDF4, SRPRB, TTN, USP15, HOOK2, NDUFA5, PDE12, VCP, CLTA, MAP1B, TUBA1A, SRRM2, CUL1, QDPR, SEC24B, TNRC6C, PRPF8, GPSM1, PLD2, DROSHA, KRT4, C17orf85, DNAJB1, FANCI, MRPS18B, RRS1, PSMC2, RFC2, CUL4B, KPNA3, RBM10, PSMC1, CPSF1, DNAJB6, SMC3, G3BP2, SHMT2, G3BP1, HSP90B1, P4HA1, SF3B2, TCEB1, WDR5, ZC3HAV1, ZCCHC3, FLNA, SND1, YWHAB, HAT1, SNRNP200, ABTB1, AIM1, ATP6V1A, BCDIN3D, BCL7A, BTBD7, FAM208B, C11orf57, RHNO1, VIPAS39, C20orf196, NYAP1, RPP25L, CCDC39, CKMT1B, CKMT1A, CTNNB1, DGCR8, DLG5, DPAGT1, DYNC1LI2, MTFR2, CMTR1, IPO5, IPO8, KCTD17, KCTD21, KEL, KNDC1, LOC646377, KCTD9P3, LPL, LZTR1, METTL15, MIPEP, MRPL2, MRPL21, MTMR3, MTMR9, N4BP1, NAALADL2, NVL, OR2T35, PCDHA6, PDPR, PIK3R1, POLR1C, PON2, PPIG, PSMC5, PTPRT, PXDNL, RBMS2, RNF219, SCO2, SEPHS1, SEPT10, SLC25A23, TAF5, TMTC2, UST, WBSCR22, WDR81, XAB2, ZBTB10, ZFP36L2, RNPS1, RPS3A, SEC13, SPTBN1, EFTUD2, POP1, SUCLG2, TFAM, CCAR2, POLR2B, RCN2, RPL7, TOE1, CD2BP2, PYCRL, RPP30, SDF2L1, ACLY, AKAP8, BTBD8, GRB2, KIF13B, MRPS35, SEC23B, SMARCB1, TFG, YTHDC2, DDB1, MSH6, RPSAP12, SKP1, ZMYM4, BSG, CPSF2, FAM103A1, GRSF1, PELO, SF1, SRRM1, ACIN1, AP2M1, ARHGDIA, ASPM, BBS4, CBWD2, CCDC110, CD84, CNNM4, CPN2, DDX28, ERC1, FAR1, FTSJ1, FUCA2, GCLM, GVINP1, HTATSF1, LARP1B, EIF2D, MASP1, MRPL28, MSI2, MTA2, NLE1, NOSIP, NUDT16L1, NUP50, PCID2, PKP2, PRKAR1B, RBM22, RTEL1, THADA, TIPRL, TTC7B, UGGT1, ZC3H18, ZRANB2, AGL, DARS, KCTD13, PDXK, RBM4, RPSAP15, ALDH3A2, EXOSC10, KCTD12, MRPS23, PDCD11, PRMT5, TNRC6A, BRIX1, DIS3, EIF4G1, MRPL1, MRPL45, MRPS22, MRPS26, PHAX, SNRPA, TNRC6B, UBR5, ARID1A, CANX, FUCA1, HUWE1, IRS4, MCCC2, USP25, AMOT, AP1B1, ARMC8, ASPH, ATP1A1, ATP1A4, ATXN10, BCKDHB, BCLAF1, C11orf70, DDX41, DDX6, DHX36, DICER1, GPT2, HBS1L, HMGB3P1, METTL13, MRPL11, MRPS9, PJA2, POLD1, PRKDC, PURB, RBM4B, RPN1, SNRPA1, SS18L1, SUPV3L1, TMEM165, TXNDC5, UBAP2, UPF1, XPNPEP3, YARS2, ATAD3B, DNAJB11, FARSA, PRPF39, PUF60, RBM45, TRMT10C, RNMT, SF3B1, SRPK1, TTC5, TRMT6, YWHAE, ACBD3, CAD, CAMK2G, CLCC1, DDX24, DYNLT1, EIF3G, ERAL1, H2AFV, P3H1, MACF1, MAGED1, MRPL14, MRPL24, MRPL37, MRPL44, NACA, NDUFS1, NSUN2, NUP153, PWP2, RBM17, RCBTB1, RRBP1, SAV1, SF3A2, SRPK2, SSR1, TRIM33, TTC37, USP32, AGO2, EIF4A1, EXOSC9, FBXO3, FECH, FTSJ3, HSD17B10, NXF1, RBM7, RPA2, CLPB, EBNA1BP2, FN3KRP, GNB2L1, HSPA8, NCAPG, NSF, NUP160, OPA1, PDHA2, PDHB, PRKACA, RCN1, SLC25A22, SMARCE1, SPATA5L1, SRP72, TARBP2, TARDBP, TFB2M, TPM3, MCMBP, CSTF3, CUL5, DPF2, AGO1, FARS2, GCAT, HNRNPM, IGF2BP3, KRT33B, MRPL12, MRPL50, MYEOV2, NCBP1, NCL, PFKM, PPP4C, RAE1, RPS11, RPS26P54, SNW1, U2SURP, TIMM50, UBA1, UBAP2L, WDR77, AURKAIP1, ALDH18A1, ATP1A2, ATP5B, PBDC1, DDX1, DDX3X, DDX46, FAM98B, FLNC, FUS, GTF3C5, HNRNPH1, IKBKAP, MEPCE, MOV10, MRPS21, MRPS27, MYBBP1A, NOP2, PEF1, PSPC1, RUVBL1, SARS2, SRSF4, SKIV2L2, SMARCD2, SNRPF, SNX9, TKT, TUBB4B, USP9X, YLPM1, YTHDF1, ADSS, BAG5, AAR2, CALM1, CALM2, CALM3, CAPZA1, CKAP4, CLINT1, CLTC, DHX30, DHX8, DHX9, EIF1AY, EIF3I, FAM120B, FAM98A, HLA-H, HNRNPA2B1, HNRNPUL1, HSPA9, IPO4, LDHB, MCM7, MRPL39, MRPL4, MRPS34, MTDH, NKRF, NOP56, NPEPPS, NUP214, PABPC1, PCBP2, PHB, PPP1CA, PRPF31, PSMD2, PURA, SAFB2, SMN2, SMN1, SRP68, TUBB6, ABCD3, ACTR2, ANKFY1, ATP2A2, ATP5C1, BOP1, RTCB, CARM1, CDC45, CPNE7, CPSF6, EIF3CL, EIF3C, EMD, EXOSC6, FAM120A, GBAS, GFPT2, GMPPA, GPRASP2, HSPA5, KPNA2, KRT1, KRT31, KRT36, KRT85, LARP1, SLC3A2, MAGED2, NIFK, NUDT21, NUP93, PFKP, PPIH, PPP1CB, PRDX4, PRPF4, PSMD1, RBM28, RBM3, RBM39, RPL35, RPS19, RRP15, SF3B3, SRSF2, SMNDC1, SNRPD2, SUPT16H, TARS2, TCP1, TUBA4A, U2AF2, VIM, VPS4B, ABCE1, AIFM1, BAG4, BOLA2, BOLA2B, C14orf166, C1orf35, DLGAP3, DNAJC10, DNAJC9, EIF4A3, EIF6, EWSR1, FXR2, GPN1, HNRNPA3, HNRNPL, HNRNPUL2, KRT9, LUC7L2, MAD2L1, MAPKAPK2, NAP1L1, PABPC4, PES1, PHGDH, PLOD1, PRMT1, PRPF19, RBM14, RBFOX2, RPN2, RPS5, RUVBL2, SRSF5, SMARCA4, SMARCC1, SNRPB, STAU1, TBL2, TCEB2, TIAL1, ZCCHC8, ACADM, ACTR1B, AHSA1, FBF1, AP2B1, ARL1, CCT2, CCT3, YBX3, DDX21, DNAJA2, DNAJC7, EIF4B, ENO1, EPPK1, GALK1, HNRNPH3, HNRNPK, HSP90AB2P, IGF2BP1, ILF3, ILVBL, IRAK1, KHSRP, KRR1, LANCL1, MARS, MATR3, MRPL49, MRPS15, NAT10, NONO, NT5DC2, PCNA, PDCD6IP, PDHA1, PLOD3, POLR2C, POLR2E, POLRMT, PPP1R15A, RARS, RBMX, RPL10P16, RPL37A, RPL5, RPL7L1, RPS17, RRP1B, SRSF3, SLC25A3, SMC1A, SMU1, SNRNP70, SPTAN1, SSR4, TAF15, TROVE2, TUBA4B, TUBB2A, UMPS, USP7, VARS, WDR18, XRN2, YTHDF2, YWHAH, YWHAQ, AGK, AHCY, ATP2A1, ATP5A1, CCDC47, CCT5, CDC5L, CIRBP, DAZAP1, DDX5, EXOSC5, FKBP8, GMPS, GTPBP1, HNRNPC, HNRNPF, KPNA4, KRT16, KRT6B, LARP4, LARS, LGALS3BP, MAT2A, MMS19, MRPS7, MRTO4, MTHFD2, NPM1, NUP155, NUP205, PPP2CA, PSMC4, PTBP1, PYCR1, RPL10A, RPL17, RPL26L1, RPL36AP37, HNRNPH2, RPS3, RPS7, RSL1D1, SAMHD1, SDHA, SEC23A, SEC24C, SSBP1, STRBP, TARS, TIA1, TRIM28, TUBA1C, TUBA3D, TUBA3C, TUBB1, TUBB4A, TUFM, YBX1, ZFR, AK2, BAG2, C1QBP, NTPCR, YAE1D1, C8orf33, DDX17, DDX50, DHX15, DSP, EEF1G, EPRS, FASN, FBL, GART, GTF2I, HIST1H4J, HIST4H4, HIST1H4E, HIST1H4H, HIST1H4K, HIST2H4A, HIST1H4D, HIST1H4F, HIST2H4B, HIST1H4C, HIST1H4B, HIST1H4I, HIST1H4L, HIST1H4A, HNRNPA0, HNRNPR, HP1BP3, HSPA1A, HSPA1B, HSPA1L, KRT10, MCM6, MRPS5, MTHFD1L, NDUFS3, NUP107, PABPN1, PGRMC1, PPP2R2A, PTCD3, PTPLAD1, QARS, RFC5, RPL3, RPL6, RPLP0, RPS10, RPS12, RPS14, RPS21, SEP15, SF3B4, SRSF1, SRSF9, SLC16A1, SLC1A5, SNRPD1, SNRPE, SS18, SYNCRIP, TRA2B, TRIP13, TUBB, TUBB3, YWHAZ, ACAT1, ACTB, ADAR, ALDOA, BUB3, CDK4, CKB, CLTCL1, CTPS1, DDX4, DNAJA1, DNAJA3, EEF1A2, EEF1B2, EIF2AK2, FXR1, TECR, GRWD1, HAX1, HNRNPA1, HNRNPDL, HPRT1, HSP90AA1, HSPB1, HSPH1, IARS, ILF2, ILK, CCT4, KHDRBS1, KPNA6, KRT2, LSM12, MTHFD1, NDUFA4, NDUFA4P1, P4HB, PCMT1, PKM, POLDIP2, PRDX3, PSMA5, RPL23, RPL35A, RPL9, RPLP2, RPS13, RPS15, RPS2, RPS25, RPS7P4, RRP12, SRSF11, SNRPG, SRRT, SSB, ALYREF, TIMM13, U2AF1, YWHAG, ZNF326, ACTBL2, ACTL6A, ACTR1A, ALDH1B1, ATAD3A, CCT6A, CSTB, DCD, DDX18, LDHD, EEF1A1, ELAVL1, GAPDH, GNL3, HNRNPAB, HNRNPD, HSP90AA2P, IGF2BP2, KPNB1, KRT5, KRT78, LDHA, LYAR, PAICS, PFN1, PPP2R1A, PRPH, RPL22, RPL23A, RPL36, RPL4, RPL8, RPS20, RPS8, SEC24A, SNRPC, SRP14, TOP1, TRA2A, TUBB2B, UBC, AMPD1, CCT7, EEF2, EIF5A2, ENO2, FAU, GSTP1, HIST1H1C, HIST2H2BE, HSP90AB1, KRT13, KRT14, KRT71, KRT76, MCM3, NAP1L4, PCBD1, PRDX1, PWP1, QPCT, RBMXL2, RPL11, RPL12, RPL13P12, RPL14, RPL15, RPL18, RPL19, RPL21P19, RPL21, RPL21P16, RPL24, RPL27, RPL30, RPL31, RPL38, RPL7A, RPLP1, RPS15A, RPS16, RPS18, RPS24, RPS4X, RPS6, RPS9, SDHB, SERBP1, SLC25A5, SLC25A6, SMARCC2, SNRPB2, TRAP1, XRCC5, ACTA2, CCT8, HNRNPCL1, KRT24, KRT75, NFKB1, PDIA6, PPIA, RPL13, RPL13A, RPL7AP27, SNRPD3, CUL4A, ANK1, ESR1, UBE2E3, UBE2E1, UBE2E2, CDC34, UBE2D2, RCBTB2, UBE2M, RFWD2, CASP8, APP, PPP2R2B, TNFRSF10B, TNFRSF10A, FADD, DDIT3, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, KLHL3, WNK4, CCDC22, COMMD8, DAXX, CAMK1D, EFNB1, WNT7B, HLA-DMB, CDC25A, FOLR1, DYRK4, OLIG2, DLC1, GORASP2, ME1, TBCD, OIP5, BCL6, GMCL1P1, MYNN, NLRP1, FMOD, CIITA, LRRC8B, RTN4RL1, PRAMEF8, ERBB2IP, LRRK1, LRFN2, LRRC7, PAK1IP1, HIRA, DMWD, COPB2, TRIM3, TRIM32, UTP15, BRWD1, FBXW5, WDR91, WDTC1, PHIP, WDR35, WDR48, POC1B, WDR76, DPH7, WDR90, WDR1, WDFY4, LRR1, UBE2D1, ZMAT4, BRMS1, RNF7, DRD4, ARIH1, CUL2, TXLNA, RPUSD2, SBDS, TBC1D24, NTRK1, MEMO1, MAP1LC3B, GABARAP, MAP1LC3C, HIST1H2BG, CLK1, ERG, UBASH3B, ZNF711, FAM193B, PALB2, SENP3, ARRB2, ARRB1, GLI2, DVL2, USP21, AURKA, EGLN2, ZNF444, KLHL10, TCEB3, MTNR1A, MTNR1B, RBBP8, NOTCH1, PHLPP2, BRD4 | PCMTD1 | ELAVL1, CUL5, MRPS11, NANOG, RPS14, SEPT3, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL3_PCMTD1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL3_PCMTD1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CUL3 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | CUL3 | C3469606 | PSEUDOHYPOALDOSTERONISM, TYPE IIE | 1 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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