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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8979

FusionGeneSummary for CUL2_CYP2C18

check button Fusion gene summary
Fusion gene informationFusion gene name: CUL2_CYP2C18
Fusion gene ID: 8979
HgeneTgene
Gene symbol

CUL2

CYP2C18

Gene ID

8453

1562

Gene namecullin 2cytochrome P450 family 2 subfamily C member 18
Synonyms-CPCI|CYP2C|CYP2C17|P450-6B/29C|P450IIC17
Cytomap

10p11.21

10q23.33

Type of geneprotein-codingprotein-coding
Descriptioncullin-2CUL-2testis secretory sperm-binding protein Li 238Ecytochrome P450 2C18(S)-mephenytoin hydroxylase associated cytochrome P450CYPIIC18cytochrome P450, family 2, subfamily C, polypeptide 18cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17cytochrome P450, subfamily IIC (mephenyt
Modification date2018052320180523
UniProtAcc

Q13617

P33260

Ensembl transtripts involved in fusion geneENST00000374746, ENST00000374748, 
ENST00000374749, ENST00000374751, 
ENST00000602371, ENST00000374742, 
ENST00000537177, ENST00000478044, 
ENST00000339022, ENST00000285979, 
Fusion gene scores* DoF score3 X 2 X 3=183 X 1 X 3=9
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CUL2 [Title/Abstract] AND CYP2C18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-V1-A9ZK-01ACUL2chr10

35379358

-CYP2C18chr10

96447527

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000374746ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374746ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374748ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374748ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374749ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000374749ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374751ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374751ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000602371ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000602371ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374742ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
5UTR-3CDSENST00000374742ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000537177ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000537177ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000478044ENST00000339022CUL2chr10

35379358

-CYP2C18chr10

96447527

+
intron-3CDSENST00000478044ENST00000285979CUL2chr10

35379358

-CYP2C18chr10

96447527

+

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FusionProtFeatures for CUL2_CYP2C18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUL2

Q13617

CYP2C18

P33260

Core component of multiple cullin-RING-based ECS(ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligasecomplexes, which mediate the ubiquitination of target proteins.ECS complexes and ARIH1 collaborate in tandem to mediateubiquitination of target proteins (PubMed:27565346). May serve asa rigid scaffold in the complex and may contribute to catalysisthrough positioning of the substrate and the ubiquitin-conjugatingenzyme. The E3 ubiquitin-protein ligase activity of the complex isdependent on the neddylation of the cullin subunit and isinhibited by the association of the deneddylated cullin subunitwith TIP120A/CAND1. The functional specificity of the ECS complexdepends on the substrate recognition component. ECS(VHL) mediatesthe ubiquitination of hypoxia-inducible factor (HIF).{ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984,ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:9122164}. Cytochromes P450 are a group of heme-thiolatemonooxygenases. In liver microsomes, this enzyme is involved in anNADPH-dependent electron transport pathway. It oxidizes a varietyof structurally unrelated compounds, including steroids, fattyacids, and xenobiotics.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CUL2_CYP2C18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CUL2_CYP2C18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CUL2RNF7, VHL, P4HB, CAB39, TFE3, TIMM13, STOM, RPL35P5, PFKFB3, RNMTL1, KCTD5, CMBL, DLG3, CAND1, RBX1, TCEB2, TCEB1, DCUN1D1, SAP130, ASB4, COPS5, COPS6, TCEAL1, HIF1A, COMMD1, KLHDC10, SH3GLB1, COPS3, KEAP1, ARID1B, ARID1A, COPS2, UBE2D1, RELA, DNMT3B, ARNT, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, VCP, KAT2A, ADRB2, ASB2, MED8, FBXW8, GLMN, PFDN5, SKP2, SQSTM1, NEDD8, PRAME, BCL2L11, TOP2A, ZYG11B, ZER1, FEM1B, APPBP2, KLHDC2, KLHDC3, PCMTD2, CUL5, ABCF1, ACLY, ACTA2, ACTB, ACTBL2, AGL, AIFM1, AKAP8L, FBF1, ALDOA, ANKRD39, ANXA2, ANXA2P2, APOD, ASPRV1, BAG4, BOLA2, BOLA2B, BRAP, BTG3, EDRF1, C11orf70, C14orf166, C1QBP, RTCB, VWA7, YAE1D1, DFFB, CARM1, CASP14, CDKN2A, CEP152, CIRBP, CLTC, COPS4, COPS7A, COPS7B, COPS8, LUC7L3, YBX3, CSTA, CTPS1, CTSD, CUL4B, DAZAP1, DCD, DDX1, DDX17, DDX56, DDX3X, DDX5, DERL2, DHX15, DHX9, DNAJA1, DNAJB6, DNAJC10, DSG1, DSP, EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1G, EGFLAM, AGO2, EIF5A, ELAVL1, EMD, ENO1, ENO2, EWSR1, FAM103A1, FAM98A, FEM1A, FEM1C, FLG, FLG2, FUS, GAPDH, GDPD3, GLDC, GPS1, GRSF1, GSTP1, HIST1H1C, HIST2H2BE, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPCL1, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPK, HNRNPM, HNRNPR, HNRNPU, HNRNPUL1, HNRNPDL, HRNR, HSP90AA1, HSP90AA2P, HSP90AB1, HSP90AB2P, HSP90B1, HSPA1A, HSPA1B, HSPA1L, HSPA5, HSPA7, HSPA8, HSPA9, TRMT112, HSPD1, IGF2BP1, IGKV4-1, ILF2, ILF3, IRS4, JUP, KDELC1, KHSRP, KLC3, PPP1R21, KRT1, KRT10, KRT13, KRT14, KRT16, KRT2, KRT24, KRT5, KRT6A, KRT6C, KRT71, KRT75, KRT76, KRT78, KRT9, LARP1, LGALS3BP, IGHV3OR15-7, LOXL1, LRRC14, MCM3, MLPH, MORC2, MRTO4, MTHFD1, MTHFSD, MYEOV2, NAP1L1, NCL, NFRKB, NKAPL, NONO, NPM1, NUCB2, NUDT1, NUP214, NUP88, PABPC1, PABPC4, PABPN1, PARP14, PCBP1, PCBP2, PCMT1, PCNA, PDCD6, PEPD, PHGDH, PKM, PLOD1, POLR2A, POP7, PPFIA1, LRR1, PRDX1, PRDX2, PRDX3, PRDX4, PRMT1, PRPF39, PSMD4, PTOV1, QPCT, RANBP2, RBM14, RBM4, RBM3, RCBTB1, RNF187, RNMT, RNPS1, RPL10P16, RPL11, RPL12, RPL13, RPL13P12, RPL14, RPL15, RPL18, RPL19, RPL21P19, RPL21, RPL21P16, RPL22, RPL23, RPL23A, RPL24, RPL27, RPL27A, RPL28, RPL29P11, RPL29P30, RPL3, RPL31, RPL36, HNRNPH2, RPL36AP37, RPL38, RPL4, RPL5, RPL6, RPL7, RPL7P32, RPL7AP9, RPL7AP27, RPL8, RPL9, RPLP0, RPLP1, RPLP2, RPS13, RPS14, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS23, RPS24, RPS25, RPS27, RPS3, RPS3A, RPS4X, RPS6, RPS8, RPS9, RPSAP12, RPSAP55, S100A9, SAMHD1, SDHA, SDHB, SEC23A, SERPINB12, SERPINB3, SERPINB4, SF3B3, SRSF1, SRSF2, SRSF3, SRSF6, SRSF7, SLC16A1, SLC25A3, SLC25A5, SMAD6, SMC3, SMPD4, SNRNP200, SNRNP70, SNRPA, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNW1, SSB, SYNCRIP, TAF15, TBC1D15, TBC1D17, TBC1D4, TCEB1P3, TFG, ALYREF, TIA1, TIAL1, TMCC3, TNRC6B, TRA2B, TRIM28, TRIM44, TRIM9, TTN, TUBA1C, TUBA4A, TUBB, TUBB1, TUBB2A, TUBB4B, TUFM, TXN, UBC, UBE2M, UBR1, USP25, WDR77, YBX1, YWHAQ, YWHAZ, ZCCHC11, ZRANB3, HIST1H4J, HIST4H4, HIST1H4E, HIST1H4H, HIST1H4K, HIST2H4A, HIST1H4D, HIST1H4F, HIST2H4B, HIST1H4C, HIST1H4B, HIST1H4I, HIST1H4L, HIST1H4A, PTPN14, LAGE3, OSGEP, CISH, GNB2L1, KLF4, MKNK2, RFWD2, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, PLK1, FBXL2, CCDC22, AR, DLC1, ATP6V1B2, CTNNA1, DPYSL3, MSH2, NARS, ST13, XRCC5, XRCC6, KPNB1, NDRG1, CSNK1E, SHFM1, SHMT2, MOV10, NXF1, CDC34, SENP8, ARIH1, MRM1, SKAP1, TSGA10IP, RHOB, UNK, ATP6V1D, CIAPIN1, CUL3, NTRK1, TARDBP, EPOR, SLBP, PYCARD, OXT, PRAMEF17, IKZF1, AVP, SYCE3, RGS20, BRCA1CYP2C18A2M, ECSIT, APOE, PSEN1, SDC2, ACAD8, CYP2C9, SLC7A2, AMZ2, TMEM260


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CUL2_CYP2C18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CUL2_CYP2C18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCUL2C0021390Inflammatory Bowel Diseases1CTD_human
TgeneCYP2C18C0033578Prostatic Neoplasms1CTD_human
TgeneCYP2C18C0206726gliosarcoma1CTD_human