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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8976

FusionGeneSummary for CUL1_GIMAP5

check button Fusion gene summary
Fusion gene informationFusion gene name: CUL1_GIMAP5
Fusion gene ID: 8976
HgeneTgene
Gene symbol

CUL1

GIMAP5

Gene ID

8454

55340

Gene namecullin 1GTPase, IMAP family member 5
Synonyms-HIMAP3|IAN-5|IAN4|IAN4L1|IAN5|IMAP3|IROD
Cytomap

7q36.1

7q36.1

Type of geneprotein-codingprotein-coding
Descriptioncullin-1CUL-1GTPase IMAP family member 5immune associated nucleotide 4 like 1immune-associated nucleotide-binding protein 5immunity associated protein 3immunity-associated nucleotide 5 proteininhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
Modification date2018052320180523
UniProtAcc

Q13616

Q96F15

Ensembl transtripts involved in fusion geneENST00000409469, ENST00000602748, 
ENST00000325222, 
ENST00000358647, 
ENST00000479556, 
Fusion gene scores* DoF score4 X 6 X 3=721 X 1 X 1=1
# samples 61
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CUL1 [Title/Abstract] AND GIMAP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCUL1

GO:0016567

protein ubiquitination

15103331

HgeneCUL1

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

15103331


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-B6-A0IN-01ACUL1chr7

148484212

+GIMAP5chr7

150437967

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000409469ENST00000358647CUL1chr7

148484212

+GIMAP5chr7

150437967

+
5CDS-intronENST00000409469ENST00000479556CUL1chr7

148484212

+GIMAP5chr7

150437967

+
5CDS-5UTRENST00000602748ENST00000358647CUL1chr7

148484212

+GIMAP5chr7

150437967

+
5CDS-intronENST00000602748ENST00000479556CUL1chr7

148484212

+GIMAP5chr7

150437967

+
5CDS-5UTRENST00000325222ENST00000358647CUL1chr7

148484212

+GIMAP5chr7

150437967

+
5CDS-intronENST00000325222ENST00000479556CUL1chr7

148484212

+GIMAP5chr7

150437967

+

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FusionProtFeatures for CUL1_GIMAP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUL1

Q13616

GIMAP5

Q96F15

Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, whichmediate the ubiquitination of proteins involved in cell cycleprogression, signal transduction and transcription. SCF complexesand ARIH1 collaborate in tandem to mediate ubiquitination oftarget proteins (PubMed:27565346). In the SCF complex, serves as arigid scaffold that organizes the SKP1-F-box protein and RBX1subunits. May contribute to catalysis through positioning of thesubstrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on theneddylation of the cullin subunit and exchange of the substraterecognition component is mediated by TIP120A/CAND1. The functionalspecificity of the SCF complex depends on the F-box protein assubstrate recognition component. SCF(BTRC) and SCF(FBXW11) directubiquitination of CTNNB1 and participate in Wnt signaling.SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA.SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3,SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/orSCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143,PubMed:25503564). SCF(SKP2) directs ubiquitination ofphosphorylated CDKN1B/p27kip and is involved in regulation of G1/Stransition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2,ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7)directs ubiquitination of cyclin E, NOTCH1 released notchintracellular domain (NICD), and probably PSEN1. SCF(FBXW2)directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitinationof MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5.SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directsubiquitination of BCL6 and DTL but does not seem to directubiquitination of TP53. SCF(BTRC) mediates the ubiquitination ofNFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees theassociated NFKB1-RELA dimer to translocate into the nucleus and toactivate transcription. SCF(CCNF) directs ubiquitination ofCCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2.SCF(FBXO10) directs ubiquitination of BCL2.{ECO:0000269|PubMed:15531760, ECO:0000269|PubMed:15640526,ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:19679664,ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23263282,ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25503564,ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:27565346,ECO:0000269|PubMed:9663463}. Required for mitochondrial integrity and T-cellsurvival. May contribute to T-cell quiescence (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CUL1_GIMAP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CUL1_GIMAP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CUL1RAC2, RNF7, FBXO4, RPRM, TBK1, CDT1, SKP2, CDCA3, PARK2, SKP1, CAND1, RBX1, BTRC, FBXW7, FBXW11, CDK9, FBXO7, FBXW2, FBXL3, FBXO18, E2F1, DCUN1D1, NLK, HIPK2, BORA, SAP130, COPS8, CHUK, COPS5, COPS6, OSBPL10, SLX4IP, SLX1B, PTGS2, ZC3HC1, PMS1, FBXO11, TRIM21, PSMA6, PSMA4, PSMA2, PSMD4, PSMA7, FBXO31, CDC34, COPS3, GPS1, COPS2, COPS4, SMAD3, GCM1, CDC25A, MYC, RBL2, SNRNP70, NFKBIA, CTNNB1, CENPE, RASSF1, TP73, CCND1, FBXW8, COMMD1, CUL1, DNMT3B, CLU, UBC, ING3, IKBKB, IKBKG, THRA, CORO7, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, VCP, FBXO8, FBXL5, FBXO42, MDM2, RICTOR, ASB2, MED6, KDM2B, GLMN, FBXL2, SQSTM1, KDR, NEDD8, FBXO25, FBXO6, FBXO44, CSN2, YBX1, HSPA4, HSPD1, FBXO2, FBXO17, FBXO27, IRF3, CAND2, PPP1CA, CUL4A, CHEK1, COPS7A, VPRBP, CCNF, KDM4A, CUL3, CUL5, FBXL18, PSMF1, FBXO9, FBXO30, FBXO33, FBXL8, MYO1D, FBXL15, EFCC1, KIR3DX1, FBXO21, FBXO3, FBXW5, FBXO22, FBXO22-AS1, CCNA2, CDK2, CKS1B, HNRNPU, PSMA1, FBXO10, PSMB3, SNORA7A, RPL32, CAPRIN1, FBXW9, FBXL14, ARIH1, CCNA1, CLPX, RPS28, RPS26P54, MYO1B, RPSAP55, DYNLL1, COPS7B, CALM1, CALM2, RPL27A, CDK3, IGHV3OR15-7, LONP1, MYEOV2, RPL7P32, ACTA1, RPS3A, DLAT, RPL35, TARS, G3BP1, CA2, DBNL, ACOXL, ADAMTS17, SLC7A9, BMP8B, CCDC146, EPSTI1, EXD3, SUPT20HL1, GABRB1, LGALS8, KMT2E, MYBPC3, NAP1L2, NEXN, NUDT7, POMP, PPL, PRDM10, PSMB4, PSMG1, PSMG3, RACGAP1, RXRG, RYR3, ZBTB46, CCDC168, SPTBN1, AKAP8L, MRPS26, USP11, FBXL17, G3BP2, RPL10P16, RPSAP12, WWP2, SPTAN1, CACNA1C, CPN2, KIF5C, PDE6D, PSMA3, RPS26P11, POP1, CLTC, RPS11, POLD1, DOCK1, FBXL12, MRPL19, MYH10, SCARB1, SNX18, TFG, HSP90AB2P, RPL28, DNAJC9, GNL3, MARS, MYH3, MYL12B, MYL6, MYL6B, MYO1A, MYO1E, PSMB6, RPL36, QDPR, CBX3, GNB2L1, NOP2, PSMA5, RPL10AP3, RPL34, RPS27, CDK4, DDX56, DHX9, EEF2, EIF3L, EIF4A3, EPRS, GYS1, HNRNPUL1, HSPA8, KRT1, KRT10, MRPL11, NCBP2, PCBD1, RAE1, RCBTB1, STAU1, ZCCHC11, DDB1, DHX30, EEF1D, MRPS22, MRPS27, MYBBP1A, NCL, RBBP6, RNMT, SORL1, AGL, GPATCH4, PABPC1, PWP2, RBM3, RPL26L1, YWHAE, AIMP1, C14orf166, CLTCL1, ENO1, EWSR1, HIST1H2BL, HNRNPA2B1, HSPA9, KRT2, KRT9, MYH9, PRDX6, PWP1, RBM39, RNMTL1, RPL6, RPS19, RPS9, SKIV2L2, SLC25A43, TUBB4B, WDR5, DHX15, FUS, GRSF1, HSPA5, KCNH2, KPNA1, MPP2, MRPL12, NPM1, PRPF19, PSMB5, RPL10A, RPL18A, RPS17, RPS3, RPS4X, RPS5, RPS7, SRSF6, ALYREF, DDX5, GRWD1, GTF3C5, H1FX, HNRNPA3, HNRNPH1, HSPA1B, HSPA1A, IGF2BP1, ILF2, ILF3, MRPL49, PPAN, PURA, RPL21P19, RPL21P16, RPL21, RPL27, RPL3, RPL30, RPL4, RPL5, RPL7L1, RPL9, RPLP0, RPS21, SRSF3, SNRPD2, SYNCRIP, XRN2, ACTA2, ACTB, CBR1, CIRBP, DDX1, DDX3X, HNRNPD, HNRNPK, HNRNPM, HSP90AA1, KARS, KPNA2, LYAR, NKRF, NUDT16L1, PABPC4, PPP1CC, PPP2CA, PTBP1, RPL12, RPL23, RPL7AP9, RPS15A, RPS15AP25, RPS18, RPS2, RPS6, RSL1D1, SRSF1, SREK1, SHMT2, SNRPB, SNRPD1, SSB, SSBP1, BCAS2, C1QBP, EIF6, FARSA, HIST1H1C, HNRNPAB, HNRNPF, HNRNPR, HNRNPDL, HP1BP3, HSP90B1, HSPA1L, HSPA6, KRT16, LGALS3BP, NSUN2, NUDT1, PCMT1, QARS, RBM14, RBM4, RBM28, RNPS1, RPL10L, RPL13A, RPL15, RPL36AP37, HNRNPH2, RPLP2, RPS10, RPS12, RPS13, RPS14, RPS16, RPS23, RPS24, RPS25, RPS8, SF3B4, SRSF5, SRP14, TIAL1, TRA2B, TUBA4A, TUBB, ACAT1, FBF1, BRIX1, C7orf50, CKB, YBX3, DARS, DAZAP1, DNAJC10, EBNA1BP2, EEF1B2, AGO2, ELAVL1, HNRNPA1, HNRNPC, HNRNPH3, KRT13, KRT14, KRT6B, LARP1, MATR3, MRPS23, NAT10, NXF1, PCBP2, PCNA, PDIA6, PDXK, PKM, PLOD1, PPIA, PRDX3, QPCT, RARS, RPL19, RPL23A, RPL31, RPL35A, RPL37A, RPS15, RPS20, RPS7P4, RRP12, SDHB, SEC23A, SF3B1, SRSF2, SNRPA, SNRPE, SNRPG, STRBP, TAF15, TIA1, TIMM13, TRIM28, U2AF1, U2AF2, ACTR1A, ATAD3A, BAG4, RTCB, DFFB, CCBL2, CDC5L, LUC7L3, DDX18, EEF1A1, EEF1G, EIF4A1, SNORA67, FAM98A, HIST2H2BE, HNRNPA0, HNRNPCL1, HSD17B10, HSPA7, KRT5, KRT6A, NAP1L1, PDCD6, RPL11, RPL13, RPL13P12, RPL18, RPL22, RPL24, RPL38, RPL7AP27, RPL8, RPLP1, SDHA, SERBP1, SRSF4, SRSF7, SNRPC, U2SURP, TIMM50, TNRC6B, TOP1, TPI1, TPI1P1, TUBA1C, TUBB1, TUBB4A, UGGT1, YWHAZ, AHCY, AIFM1, AMPD1, ATP5A1, CARM1, CCT2, CTPS1, DLGAP3, DDX17, DNAJA1, EEF1A2, ENO2, FAU, FTSJ3, HNRNPL, HSP90AA2P, HSP90AB1, IRS4, KHSRP, KRT24, KRT6C, KRT75, NAP1L4, NCBP1, PABPN1, PRDX1, RBMXL2, RPSAP15, RPSA, SLC25A5, SLC25A6, SNRPB2, SNRPD3, VIM, ACTBL2, CCT8, GAPDH, ILK, CCT4, PRDX2, RPL14, RPL29P30, RUVBL2, SF3B3, TXN, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, CSN1S1, PML, CDKN1B, IRAK1, UBE2E3, TRRAP, USP37, BTG1, BTG2, FBXL22, UBE2M, SENP8, DEPTOR, RFWD2, FBXL20, CHEK2, CDKN1A, CCDC6, UHRF1, DDIT3, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, FBXW4, BRAP, SCNN1D, CCDC22, COMMD8, CRY1, CRY2, RANBP2, FZR1, FBXO34, FBXL21, DLC1, CRMP1, CSDE1, HIST1H4A, NUDT5, PPP1R12A, SSRP1, UGP2, SWAP70, TRIM47, MTSS1, EZH2, OIP5, TFAP4, RPA3, RPA2, RPA1, PTTG1, NEDD4, CCNY, NUAK1, ASF1A, SHFM1, FBXO46, DAB2IP, NABP2, UBE2F, ESR1, EED, IDS, DCX, TSC22D4, TRIM49, PDE12, PSMD12, SGTA, NTRK1, STIL, GATA2, RBPJ, GHR, FBXO24, MAGEC2, KLF4, SNW1, FBXL7, SENP3, CREB3L3, ARID1A, TRIB2, DRG2, CDC73, LPIN1, AIRE, SLBP, CDC25B, FBXO40, KHDRBS2, TRAF1, ZNF704, HAL, GNS, CST6, SMTNL2, TINAG, NEFH, EID1, DKK4, SERPINA12, ECM1, SPANXN3, STYX, TENC1, FBXO32, MCL1, DLEU2, BRD4GIMAP5APP, EDA, STX4, GRAMD3, LSMEM2, LDLRAD1, BCL2, BCL2L1, BAX, BAK1, BAD, BCL2L11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CUL1_GIMAP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CUL1_GIMAP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCUL1C0038325Stevens-Johnson Syndrome1CTD_human