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Fusion gene ID: 8976 |
FusionGeneSummary for CUL1_GIMAP5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CUL1_GIMAP5 | Fusion gene ID: 8976 | Hgene | Tgene | Gene symbol | CUL1 | GIMAP5 | Gene ID | 8454 | 55340 |
Gene name | cullin 1 | GTPase, IMAP family member 5 | |
Synonyms | - | HIMAP3|IAN-5|IAN4|IAN4L1|IAN5|IMAP3|IROD | |
Cytomap | 7q36.1 | 7q36.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cullin-1CUL-1 | GTPase IMAP family member 5immune associated nucleotide 4 like 1immune-associated nucleotide-binding protein 5immunity associated protein 3immunity-associated nucleotide 5 proteininhibitor of radiation- and OA-induced apoptosis, Irod/Ian5 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q13616 | Q96F15 | |
Ensembl transtripts involved in fusion gene | ENST00000409469, ENST00000602748, ENST00000325222, | ENST00000358647, ENST00000479556, | |
Fusion gene scores | * DoF score | 4 X 6 X 3=72 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CUL1 [Title/Abstract] AND GIMAP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CUL1 | GO:0016567 | protein ubiquitination | 15103331 |
Hgene | CUL1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-B6-A0IN-01A | CUL1 | chr7 | 148484212 | + | GIMAP5 | chr7 | 150437967 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000409469 | ENST00000358647 | CUL1 | chr7 | 148484212 | + | GIMAP5 | chr7 | 150437967 | + |
5CDS-intron | ENST00000409469 | ENST00000479556 | CUL1 | chr7 | 148484212 | + | GIMAP5 | chr7 | 150437967 | + |
5CDS-5UTR | ENST00000602748 | ENST00000358647 | CUL1 | chr7 | 148484212 | + | GIMAP5 | chr7 | 150437967 | + |
5CDS-intron | ENST00000602748 | ENST00000479556 | CUL1 | chr7 | 148484212 | + | GIMAP5 | chr7 | 150437967 | + |
5CDS-5UTR | ENST00000325222 | ENST00000358647 | CUL1 | chr7 | 148484212 | + | GIMAP5 | chr7 | 150437967 | + |
5CDS-intron | ENST00000325222 | ENST00000479556 | CUL1 | chr7 | 148484212 | + | GIMAP5 | chr7 | 150437967 | + |
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FusionProtFeatures for CUL1_GIMAP5 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CUL1 | GIMAP5 |
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, whichmediate the ubiquitination of proteins involved in cell cycleprogression, signal transduction and transcription. SCF complexesand ARIH1 collaborate in tandem to mediate ubiquitination oftarget proteins (PubMed:27565346). In the SCF complex, serves as arigid scaffold that organizes the SKP1-F-box protein and RBX1subunits. May contribute to catalysis through positioning of thesubstrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on theneddylation of the cullin subunit and exchange of the substraterecognition component is mediated by TIP120A/CAND1. The functionalspecificity of the SCF complex depends on the F-box protein assubstrate recognition component. SCF(BTRC) and SCF(FBXW11) directubiquitination of CTNNB1 and participate in Wnt signaling.SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA.SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3,SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/orSCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143,PubMed:25503564). SCF(SKP2) directs ubiquitination ofphosphorylated CDKN1B/p27kip and is involved in regulation of G1/Stransition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2,ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7)directs ubiquitination of cyclin E, NOTCH1 released notchintracellular domain (NICD), and probably PSEN1. SCF(FBXW2)directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitinationof MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5.SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directsubiquitination of BCL6 and DTL but does not seem to directubiquitination of TP53. SCF(BTRC) mediates the ubiquitination ofNFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees theassociated NFKB1-RELA dimer to translocate into the nucleus and toactivate transcription. SCF(CCNF) directs ubiquitination ofCCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2.SCF(FBXO10) directs ubiquitination of BCL2.{ECO:0000269|PubMed:15531760, ECO:0000269|PubMed:15640526,ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:19679664,ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23263282,ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25503564,ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:27565346,ECO:0000269|PubMed:9663463}. | Required for mitochondrial integrity and T-cellsurvival. May contribute to T-cell quiescence (By similarity).{ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL1_GIMAP5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL1_GIMAP5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CUL1 | RAC2, RNF7, FBXO4, RPRM, TBK1, CDT1, SKP2, CDCA3, PARK2, SKP1, CAND1, RBX1, BTRC, FBXW7, FBXW11, CDK9, FBXO7, FBXW2, FBXL3, FBXO18, E2F1, DCUN1D1, NLK, HIPK2, BORA, SAP130, COPS8, CHUK, COPS5, COPS6, OSBPL10, SLX4IP, SLX1B, PTGS2, ZC3HC1, PMS1, FBXO11, TRIM21, PSMA6, PSMA4, PSMA2, PSMD4, PSMA7, FBXO31, CDC34, COPS3, GPS1, COPS2, COPS4, SMAD3, GCM1, CDC25A, MYC, RBL2, SNRNP70, NFKBIA, CTNNB1, CENPE, RASSF1, TP73, CCND1, FBXW8, COMMD1, CUL1, DNMT3B, CLU, UBC, ING3, IKBKB, IKBKG, THRA, CORO7, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, VCP, FBXO8, FBXL5, FBXO42, MDM2, RICTOR, ASB2, MED6, KDM2B, GLMN, FBXL2, SQSTM1, KDR, NEDD8, FBXO25, FBXO6, FBXO44, CSN2, YBX1, HSPA4, HSPD1, FBXO2, FBXO17, FBXO27, IRF3, CAND2, PPP1CA, CUL4A, CHEK1, COPS7A, VPRBP, CCNF, KDM4A, CUL3, CUL5, FBXL18, PSMF1, FBXO9, FBXO30, FBXO33, FBXL8, MYO1D, FBXL15, EFCC1, KIR3DX1, FBXO21, FBXO3, FBXW5, FBXO22, FBXO22-AS1, CCNA2, CDK2, CKS1B, HNRNPU, PSMA1, FBXO10, PSMB3, SNORA7A, RPL32, CAPRIN1, FBXW9, FBXL14, ARIH1, CCNA1, CLPX, RPS28, RPS26P54, MYO1B, RPSAP55, DYNLL1, COPS7B, CALM1, CALM2, RPL27A, CDK3, IGHV3OR15-7, LONP1, MYEOV2, RPL7P32, ACTA1, RPS3A, DLAT, RPL35, TARS, G3BP1, CA2, DBNL, ACOXL, ADAMTS17, SLC7A9, BMP8B, CCDC146, EPSTI1, EXD3, SUPT20HL1, GABRB1, LGALS8, KMT2E, MYBPC3, NAP1L2, NEXN, NUDT7, POMP, PPL, PRDM10, PSMB4, PSMG1, PSMG3, RACGAP1, RXRG, RYR3, ZBTB46, CCDC168, SPTBN1, AKAP8L, MRPS26, USP11, FBXL17, G3BP2, RPL10P16, RPSAP12, WWP2, SPTAN1, CACNA1C, CPN2, KIF5C, PDE6D, PSMA3, RPS26P11, POP1, CLTC, RPS11, POLD1, DOCK1, FBXL12, MRPL19, MYH10, SCARB1, SNX18, TFG, HSP90AB2P, RPL28, DNAJC9, GNL3, MARS, MYH3, MYL12B, MYL6, MYL6B, MYO1A, MYO1E, PSMB6, RPL36, QDPR, CBX3, GNB2L1, NOP2, PSMA5, RPL10AP3, RPL34, RPS27, CDK4, DDX56, DHX9, EEF2, EIF3L, EIF4A3, EPRS, GYS1, HNRNPUL1, HSPA8, KRT1, KRT10, MRPL11, NCBP2, PCBD1, RAE1, RCBTB1, STAU1, ZCCHC11, DDB1, DHX30, EEF1D, MRPS22, MRPS27, MYBBP1A, NCL, RBBP6, RNMT, SORL1, AGL, GPATCH4, PABPC1, PWP2, RBM3, RPL26L1, YWHAE, AIMP1, C14orf166, CLTCL1, ENO1, EWSR1, HIST1H2BL, HNRNPA2B1, HSPA9, KRT2, KRT9, MYH9, PRDX6, PWP1, RBM39, RNMTL1, RPL6, RPS19, RPS9, SKIV2L2, SLC25A43, TUBB4B, WDR5, DHX15, FUS, GRSF1, HSPA5, KCNH2, KPNA1, MPP2, MRPL12, NPM1, PRPF19, PSMB5, RPL10A, RPL18A, RPS17, RPS3, RPS4X, RPS5, RPS7, SRSF6, ALYREF, DDX5, GRWD1, GTF3C5, H1FX, HNRNPA3, HNRNPH1, HSPA1B, HSPA1A, IGF2BP1, ILF2, ILF3, MRPL49, PPAN, PURA, RPL21P19, RPL21P16, RPL21, RPL27, RPL3, RPL30, RPL4, RPL5, RPL7L1, RPL9, RPLP0, RPS21, SRSF3, SNRPD2, SYNCRIP, XRN2, ACTA2, ACTB, CBR1, CIRBP, DDX1, DDX3X, HNRNPD, HNRNPK, HNRNPM, HSP90AA1, KARS, KPNA2, LYAR, NKRF, NUDT16L1, PABPC4, PPP1CC, PPP2CA, PTBP1, RPL12, RPL23, RPL7AP9, RPS15A, RPS15AP25, RPS18, RPS2, RPS6, RSL1D1, SRSF1, SREK1, SHMT2, SNRPB, SNRPD1, SSB, SSBP1, BCAS2, C1QBP, EIF6, FARSA, HIST1H1C, HNRNPAB, HNRNPF, HNRNPR, HNRNPDL, HP1BP3, HSP90B1, HSPA1L, HSPA6, KRT16, LGALS3BP, NSUN2, NUDT1, PCMT1, QARS, RBM14, RBM4, RBM28, RNPS1, RPL10L, RPL13A, RPL15, RPL36AP37, HNRNPH2, RPLP2, RPS10, RPS12, RPS13, RPS14, RPS16, RPS23, RPS24, RPS25, RPS8, SF3B4, SRSF5, SRP14, TIAL1, TRA2B, TUBA4A, TUBB, ACAT1, FBF1, BRIX1, C7orf50, CKB, YBX3, DARS, DAZAP1, DNAJC10, EBNA1BP2, EEF1B2, AGO2, ELAVL1, HNRNPA1, HNRNPC, HNRNPH3, KRT13, KRT14, KRT6B, LARP1, MATR3, MRPS23, NAT10, NXF1, PCBP2, PCNA, PDIA6, PDXK, PKM, PLOD1, PPIA, PRDX3, QPCT, RARS, RPL19, RPL23A, RPL31, RPL35A, RPL37A, RPS15, RPS20, RPS7P4, RRP12, SDHB, SEC23A, SF3B1, SRSF2, SNRPA, SNRPE, SNRPG, STRBP, TAF15, TIA1, TIMM13, TRIM28, U2AF1, U2AF2, ACTR1A, ATAD3A, BAG4, RTCB, DFFB, CCBL2, CDC5L, LUC7L3, DDX18, EEF1A1, EEF1G, EIF4A1, SNORA67, FAM98A, HIST2H2BE, HNRNPA0, HNRNPCL1, HSD17B10, HSPA7, KRT5, KRT6A, NAP1L1, PDCD6, RPL11, RPL13, RPL13P12, RPL18, RPL22, RPL24, RPL38, RPL7AP27, RPL8, RPLP1, SDHA, SERBP1, SRSF4, SRSF7, SNRPC, U2SURP, TIMM50, TNRC6B, TOP1, TPI1, TPI1P1, TUBA1C, TUBB1, TUBB4A, UGGT1, YWHAZ, AHCY, AIFM1, AMPD1, ATP5A1, CARM1, CCT2, CTPS1, DLGAP3, DDX17, DNAJA1, EEF1A2, ENO2, FAU, FTSJ3, HNRNPL, HSP90AA2P, HSP90AB1, IRS4, KHSRP, KRT24, KRT6C, KRT75, NAP1L4, NCBP1, PABPN1, PRDX1, RBMXL2, RPSAP15, RPSA, SLC25A5, SLC25A6, SNRPB2, SNRPD3, VIM, ACTBL2, CCT8, GAPDH, ILK, CCT4, PRDX2, RPL14, RPL29P30, RUVBL2, SF3B3, TXN, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, CSN1S1, PML, CDKN1B, IRAK1, UBE2E3, TRRAP, USP37, BTG1, BTG2, FBXL22, UBE2M, SENP8, DEPTOR, RFWD2, FBXL20, CHEK2, CDKN1A, CCDC6, UHRF1, DDIT3, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, FBXW4, BRAP, SCNN1D, CCDC22, COMMD8, CRY1, CRY2, RANBP2, FZR1, FBXO34, FBXL21, DLC1, CRMP1, CSDE1, HIST1H4A, NUDT5, PPP1R12A, SSRP1, UGP2, SWAP70, TRIM47, MTSS1, EZH2, OIP5, TFAP4, RPA3, RPA2, RPA1, PTTG1, NEDD4, CCNY, NUAK1, ASF1A, SHFM1, FBXO46, DAB2IP, NABP2, UBE2F, ESR1, EED, IDS, DCX, TSC22D4, TRIM49, PDE12, PSMD12, SGTA, NTRK1, STIL, GATA2, RBPJ, GHR, FBXO24, MAGEC2, KLF4, SNW1, FBXL7, SENP3, CREB3L3, ARID1A, TRIB2, DRG2, CDC73, LPIN1, AIRE, SLBP, CDC25B, FBXO40, KHDRBS2, TRAF1, ZNF704, HAL, GNS, CST6, SMTNL2, TINAG, NEFH, EID1, DKK4, SERPINA12, ECM1, SPANXN3, STYX, TENC1, FBXO32, MCL1, DLEU2, BRD4 | GIMAP5 | APP, EDA, STX4, GRAMD3, LSMEM2, LDLRAD1, BCL2, BCL2L1, BAX, BAK1, BAD, BCL2L11 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL1_GIMAP5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL1_GIMAP5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CUL1 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |