FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8969

FusionGeneSummary for CUEDC1_CUEDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CUEDC1_CUEDC1
Fusion gene ID: 8969
HgeneTgene
Gene symbol

CUEDC1

CUEDC1

Gene ID

404093

404093

Gene nameCUE domain containing 1CUE domain containing 1
Synonyms--
Cytomap

17q22

17q22

Type of geneprotein-codingprotein-coding
DescriptionCUE domain-containing protein 1CUE domain-containing protein 1
Modification date2018051920180519
UniProtAcc

Q9NWM3

Q9NWM3

Ensembl transtripts involved in fusion geneENST00000577830, ENST00000407144, 
ENST00000360238, ENST00000577840, 
ENST00000578357, 		ENST00000577830, 
ENST00000407144, ENST00000360238, 
ENST00000577840, ENST00000578357, 
Fusion gene scores* DoF score5 X 6 X 4=1205 X 4 X 4=80
# samples 66
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CUEDC1 [Title/Abstract] AND CUEDC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF948209CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
ChiTaRS3.1BF684426CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000577830ENST00000577830CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577830ENST00000407144CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577830ENST00000360238CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577830ENST00000577840CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577830ENST00000578357CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000407144ENST00000577830CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000407144ENST00000407144CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000407144ENST00000360238CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000407144ENST00000577840CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000407144ENST00000578357CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000360238ENST00000577830CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000360238ENST00000407144CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000360238ENST00000360238CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000360238ENST00000577840CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000360238ENST00000578357CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577840ENST00000577830CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577840ENST00000407144CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577840ENST00000360238CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577840ENST00000577840CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000577840ENST00000578357CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000578357ENST00000577830CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000578357ENST00000407144CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000578357ENST00000360238CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000578357ENST00000577840CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-intronENST00000578357ENST00000578357CUEDC1chr17

55944138

-CUEDC1chr17

55943646

+
intron-3UTRENST00000577830ENST00000577830CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000577830ENST00000407144CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000577830ENST00000360238CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-intronENST00000577830ENST00000577840CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-5UTRENST00000577830ENST00000578357CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000407144ENST00000577830CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000407144ENST00000407144CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000407144ENST00000360238CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-intronENST00000407144ENST00000577840CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-5UTRENST00000407144ENST00000578357CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000360238ENST00000577830CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000360238ENST00000407144CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000360238ENST00000360238CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-intronENST00000360238ENST00000577840CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-5UTRENST00000360238ENST00000578357CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000577840ENST00000577830CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000577840ENST00000407144CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000577840ENST00000360238CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-intronENST00000577840ENST00000577840CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-5UTRENST00000577840ENST00000578357CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000578357ENST00000577830CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000578357ENST00000407144CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-3UTRENST00000578357ENST00000360238CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-intronENST00000578357ENST00000577840CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-
intron-5UTRENST00000578357ENST00000578357CUEDC1chr17

55940349

-CUEDC1chr17

55940527

-

Top

FusionProtFeatures for CUEDC1_CUEDC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUEDC1

Q9NWM3

CUEDC1

Q9NWM3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CUEDC1_CUEDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CUEDC1_CUEDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CUEDC1_CUEDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CUEDC1_CUEDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource