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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8966

FusionGeneSummary for CUBN_TSTD3

check button Fusion gene summary
Fusion gene informationFusion gene name: CUBN_TSTD3
Fusion gene ID: 8966
HgeneTgene
Gene symbol

CUBN

TSTD3

Gene ID

8029

100130890

Gene namecubilinthiosulfate sulfurtransferase (rhodanese)-like domain containing 3
SynonymsIFCR|MGA1|gp280-
Cytomap

10p13

6q16.2

Type of geneprotein-codingprotein-coding
Descriptioncubilin460 kDa receptorcubilin (intrinsic factor-cobalamin receptor)cubilin precursor variant 1cubilin precursor variant 2cubilin precursor variant 3intestinal intrinsic factor receptorintrinsic factor-vitamin B12 receptorthiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3rhodanese domain-containing protein 3
Modification date2018051920180331
UniProtAcc

O60494

Ensembl transtripts involved in fusion geneENST00000377833, ENST00000377823, 
ENST00000452647, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 1=25
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CUBN [Title/Abstract] AND TSTD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF510089CUBNchr10

16866071

+TSTD3chr6

100009516

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000377833ENST00000452647CUBNchr10

16866071

+TSTD3chr6

100009516

+
intron-intronENST00000377823ENST00000452647CUBNchr10

16866071

+TSTD3chr6

100009516

+

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FusionProtFeatures for CUBN_TSTD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUBN

O60494

TSTD3

Cotransporter which plays a role in lipoprotein, vitaminand iron metabolism, by facilitating their uptake. Binds to ALB,MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1,APOA1, high density lipoprotein, and the GIF-cobalamin complex.The binding of all ligands requires calcium. Serves as importanttransporter in several absorptive epithelia, including intestine,renal proximal tubules and embryonic yolk sac. Interaction withLRP2 mediates its trafficking throughout vesicles and facilitatesthe uptake of specific ligands like GC, hemoglobin, ALB, TF andSCGB1A1. Interaction with AMN controls its trafficking to theplasma membrane and facilitates endocytosis of ligands. May playan important role in the development of the peri-implantationembryo through internalization of APOA1 and cholesterol. Binds toLGALS3 at the maternal-fetal interface.{ECO:0000269|PubMed:10371504, ECO:0000269|PubMed:11606717,ECO:0000269|PubMed:11717447, ECO:0000269|PubMed:14576052,ECO:0000269|PubMed:9572993}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CUBN_TSTD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CUBN_TSTD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CUBN_TSTD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCUBNO60494DB00200HydroxocobalaminCubilinsmall moleculeapproved

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RelatedDiseases for CUBN_TSTD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCUBNC0025202melanoma1CTD_human
HgeneCUBNC0236733Amphetamine-Related Disorders1CTD_human
HgeneCUBNC1306856Megaloblastic anemia due to inborn errors of metabolism1CTD_human;ORPHANET;UNIPROT
TgeneTSTD3C0023893Liver Cirrhosis, Experimental1CTD_human