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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8951

FusionGeneSummary for CTTN_MYEOV

check button Fusion gene summary
Fusion gene informationFusion gene name: CTTN_MYEOV
Fusion gene ID: 8951
HgeneTgene
Gene symbol

CTTN

MYEOV

Gene ID

2017

26579

Gene namecortactinmyeloma overexpressed
SynonymsEMS1OCIM
Cytomap

11q13.3

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionsrc substrate cortactin1110020L01Rikamplaxinems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)oncogene EMS1myeloma-overexpressed gene proteinmyeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)myeloma overexpressed gene (in a subset of t(11;14) positive multiple myelomas)oncogene in multiple myeloma
Modification date2018052220180519
UniProtAcc

Q14247

Q96EZ4

Ensembl transtripts involved in fusion geneENST00000346329, ENST00000301843, 
ENST00000527622, ENST00000376561, 
ENST00000538675, 
ENST00000441339, 
ENST00000308946, ENST00000535407, 
ENST00000541137, 
Fusion gene scores* DoF score24 X 15 X 9=324013 X 4 X 7=364
# samples 2614
** MAII scorelog2(26/3240*10)=-3.63941028474353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/364*10)=-1.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTTN [Title/Abstract] AND MYEOV [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A097-01ACTTNchr11

70260758

+MYEOVchr11

69181511

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346329ENST00000441339CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-intronENST00000346329ENST00000308946CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-intronENST00000346329ENST00000535407CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-3UTRENST00000346329ENST00000541137CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-intronENST00000301843ENST00000441339CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-intronENST00000301843ENST00000308946CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-intronENST00000301843ENST00000535407CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-3UTRENST00000301843ENST00000541137CTTNchr11

70260758

+MYEOVchr11

69181511

+
intron-intronENST00000527622ENST00000441339CTTNchr11

70260758

+MYEOVchr11

69181511

+
intron-intronENST00000527622ENST00000308946CTTNchr11

70260758

+MYEOVchr11

69181511

+
intron-intronENST00000527622ENST00000535407CTTNchr11

70260758

+MYEOVchr11

69181511

+
intron-3UTRENST00000527622ENST00000541137CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-intronENST00000376561ENST00000441339CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-intronENST00000376561ENST00000308946CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-intronENST00000376561ENST00000535407CTTNchr11

70260758

+MYEOVchr11

69181511

+
5CDS-3UTRENST00000376561ENST00000541137CTTNchr11

70260758

+MYEOVchr11

69181511

+
intron-intronENST00000538675ENST00000441339CTTNchr11

70260758

+MYEOVchr11

69181511

+
intron-intronENST00000538675ENST00000308946CTTNchr11

70260758

+MYEOVchr11

69181511

+
intron-intronENST00000538675ENST00000535407CTTNchr11

70260758

+MYEOVchr11

69181511

+
intron-3UTRENST00000538675ENST00000541137CTTNchr11

70260758

+MYEOVchr11

69181511

+

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FusionProtFeatures for CTTN_MYEOV


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTTN

Q14247

MYEOV

Q96EZ4

Contributes to the organization of the actincytoskeleton and cell shape (PubMed:21296879). Plays a role in theformation of lamellipodia and in cell migration. Plays a role inthe regulation of neuron morphology, axon growth and formation ofneuronal growth cones (By similarity). Through its interactionwith CTTNBP2, involved in the regulation of neuronal spine density(By similarity). Plays a role in the invasiveness of cancer cells,and the formation of metastases (PubMed:16636290). Plays a role infocal adhesion assembly and turnover (By similarity). In complexwith ABL1 and MYLK regulates cortical actin-based cytoskeletalrearrangement critical to sphingosine 1-phosphate (S1P)-mediatedendothelial cell (EC) barrier enhancement (PubMed:20861316). Playsa role in intracellular protein transport and endocytosis, and inmodulating the levels of potassium channels present at the cellmembrane (PubMed:17959782). Plays a role in receptor-mediatedendocytosis via clathrin-coated pits (By similarity). Required forstabilization of KCNH1 channels at the cell membrane(PubMed:23144454). {ECO:0000250|UniProtKB:Q60598,ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290,ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879,ECO:0000269|PubMed:23144454}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTTN_MYEOV


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTTN_MYEOV


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTTNSHANK2, WIPF1, CTNND1, CHD3, FER, WASL, ARHGAP17, CRB2, CASP3, MYLK, ACTR2, ACTR3, ARPC2, ARPC4, ARPC3, KCNA2, SYK, SDC3, SIRT1, EP300, HDAC6, RAD21, BTRC, ELAVL1, ARRB1, ARRB2, CD2AP, ASAP1, SH3PXD2A, PTK2, TINF2, ACD, CBLL1, CUL3, PXN, TNK2, GRB2, SDHAF2, SART3, THY1, PLAUR, UBL4A, SUCLG2, OXCT1, ABI1, NONO, CORO1B, DNM2, ATF2, NCF1, PAN2, NPM1, LMNA, ACTG1, APEH, ATG7, ATP6V1C1, CTNNA1, GARS, IDE, ME1, RDX, SHMT1, SHMT2, SSB, STAT1, VTA1, GSPT1, GSPT2, SARS, SNX1, SNX2, UGDH, RPA3, RPA2, RPA1, CTTN, CDC37, SPRR2A, OBSL1, EGFR, COPS7A, HEXIM1, MYO1E, USO1, NTRK1, EWSR1, CAPZA2, DBN1, FLNA, KIFC3, MLH1, MYH9, PPP1CB, IQGAP1, SYNCRIP, SYNPO, MYO5C, MYO19, NOP9, MYO18A, TRIM15, NEDD9, SNW1, KCNA3, SMURF1, YES1, CDH1, PDHA1, TES, KEAP1, TXNIPMYEOVPRTFDC1, CNN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTTN_MYEOV


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTTN_MYEOV


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTTNC0007137Squamous cell carcinoma1CTD_human
HgeneCTTNC0023531Leukoplakia1CTD_human
HgeneCTTNC3495559Juvenile arthritis1CTD_human