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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8925

FusionGeneSummary for CTSZ_CLIC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTSZ_CLIC1
Fusion gene ID: 8925
HgeneTgene
Gene symbol

CTSZ

CLIC1

Gene ID

1522

1192

Gene namecathepsin Zchloride intracellular channel 1
SynonymsCTSXCL1C1|G6|NCC27
Cytomap

20q13.32

6p21.33

Type of geneprotein-codingprotein-coding
Descriptioncathepsin Zcarboxypeptidase LBcathepsin B2cathepsin IVcathepsin Pcathepsin Xcathepsin Ycathepsin Z1cysteine-type carboxypeptidaselysosomal carboxypeptidase Bpreprocathepsin Pchloride intracellular channel protein 1RNCC proteinchloride channel ABPhRNCCnuclear chloride ion channel 27nuclear chloride ion channel proteinp64CLCPregulatory nuclear chloride ion channel protein
Modification date2018052320180523
UniProtAcc

Q9UBR2

O00299

Ensembl transtripts involved in fusion geneENST00000217131, ENST00000375784, 
ENST00000375779, ENST00000375780, 
ENST00000395892, ENST00000457485, 
ENST00000423804, ENST00000447369, 
ENST00000447338, ENST00000422167, 
ENST00000438708, ENST00000431921, 
ENST00000415179, ENST00000418285, 
ENST00000423055, ENST00000442045, 
ENST00000435242, ENST00000400052, 
ENST00000383404, ENST00000383405, 
ENST00000400058, ENST00000456863, 
ENST00000434202, ENST00000420458, 
ENST00000433916, ENST00000425464, 
ENST00000423143, ENST00000438750, 
ENST00000451546, 
Fusion gene scores* DoF score6 X 6 X 2=724 X 4 X 3=48
# samples 64
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTSZ [Title/Abstract] AND CLIC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTSZ

GO:0032091

negative regulation of protein binding

19433310

TgeneCLIC1

GO:0006821

chloride transport

9139710


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA309759CTSZchr20

57570433

+CLIC1chr6

3030825

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000217131ENST00000375784CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000375779CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000375780CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000395892CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000457485CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000423804CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000447369CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000447338CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000422167CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000438708CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000431921CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000415179CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000418285CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000423055CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000442045CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000435242CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000400052CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000383404CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000383405CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000400058CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000456863CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000434202CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000420458CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000433916CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000425464CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000423143CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000438750CTSZchr20

57570433

+CLIC1chr6

3030825

+
intron-intronENST00000217131ENST00000451546CTSZchr20

57570433

+CLIC1chr6

3030825

+

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FusionProtFeatures for CTSZ_CLIC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTSZ

Q9UBR2

CLIC1

O00299

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Can insert into membranes and form chloride ionchannels. Channel activity depends on the pH. Membrane insertionseems to be redox-regulated and may occur only under oxydizingconditions. Involved in regulation of the cell cycle.{ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:11195932,ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526,ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939,ECO:0000269|PubMed:9139710}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTSZ_CLIC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTSZ_CLIC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTSZ_CLIC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCLIC1O00299DB11638ArtenimolChloride intracellular channel protein 1small moleculeapproved|investigational

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RelatedDiseases for CTSZ_CLIC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTSZC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneCTSZC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCLIC1C0019693HIV Infections1CTD_human
TgeneCLIC1C0022548Keloid1CTD_human
TgeneCLIC1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCLIC1C0027627Neoplasm Metastasis1CTD_human
TgeneCLIC1C0029408Degenerative polyarthritis1CTD_human
TgeneCLIC1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCLIC1C1458155Mammary Neoplasms1CTD_human