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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8899

FusionGeneSummary for CTSB_FOXP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTSB_FOXP1
Fusion gene ID: 8899
HgeneTgene
Gene symbol

CTSB

FOXP1

Gene ID

1508

27086

Gene namecathepsin Bforkhead box P1
SynonymsAPPS|CPSB12CC4|HSPC215|MFH|QRF1|hFKH1B
Cytomap

8p23.1

3p13

Type of geneprotein-codingprotein-coding
Descriptioncathepsin BAPP secretaseamyloid precursor protein secretasecathepsin B1cysteine proteaseforkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkhead
Modification date2018052320180522
UniProtAcc

P07858

Q9H334

Ensembl transtripts involved in fusion geneENST00000434271, ENST00000353047, 
ENST00000530640, ENST00000531089, 
ENST00000453527, ENST00000415599, 
ENST00000345125, ENST00000533455, 
ENST00000534510, ENST00000525076, 
ENST00000318789, ENST00000475937, 
ENST00000493089, ENST00000484350, 
ENST00000318779, ENST00000491238, 
ENST00000498215, ENST00000468577, 
ENST00000472382, 
Fusion gene scores* DoF score12 X 7 X 6=50437 X 16 X 17=10064
# samples 1440
** MAII scorelog2(14/504*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(40/10064*10)=-4.65306001710456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTSB [Title/Abstract] AND FOXP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTSB

GO:0006508

proteolysis

7890620|8811434

HgeneCTSB

GO:0030574

collagen catabolic process

22952693

HgeneCTSB

GO:0051603

proteolysis involved in cellular protein catabolic process

22952693

TgeneFOXP1

GO:0002903

negative regulation of B cell apoptotic process

25267198

TgeneFOXP1

GO:0030316

osteoclast differentiation

18799727

TgeneFOXP1

GO:0032496

response to lipopolysaccharide

18799727

TgeneFOXP1

GO:0032680

regulation of tumor necrosis factor production

18799727

TgeneFOXP1

GO:0035926

chemokine (C-C motif) ligand 2 secretion

18799727

TgeneFOXP1

GO:0036035

osteoclast development

18799727

TgeneFOXP1

GO:0042116

macrophage activation

18799727

TgeneFOXP1

GO:0042117

monocyte activation

18799727

TgeneFOXP1

GO:0045655

regulation of monocyte differentiation

15286807

TgeneFOXP1

GO:0045892

negative regulation of transcription, DNA-templated

20950788

TgeneFOXP1

GO:0050706

regulation of interleukin-1 beta secretion

18799727

TgeneFOXP1

GO:0050727

regulation of inflammatory response

18799727

TgeneFOXP1

GO:0060766

negative regulation of androgen receptor signaling pathway

18640093

TgeneFOXP1

GO:1900424

regulation of defense response to bacterium

18799727

TgeneFOXP1

GO:1901256

regulation of macrophage colony-stimulating factor production

18799727

TgeneFOXP1

GO:2001182

regulation of interleukin-12 secretion

18799727


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-BQ-5884-01ACTSBchr8

11701829

-FOXP1chr3

71007472

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000434271ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000434271ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000434271ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000434271ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000434271ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000434271ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000434271ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000434271ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000434271ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000353047ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000353047ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000353047ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000353047ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000353047ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000353047ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000353047ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000353047ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000353047ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000530640ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000530640ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000530640ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000530640ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000530640ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000530640ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000530640ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000530640ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000530640ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000531089ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000531089ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000531089ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000531089ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000531089ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000531089ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000531089ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000531089ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000531089ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000453527ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000453527ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000453527ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000453527ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000453527ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000453527ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000453527ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000453527ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000453527ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000415599ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-3UTRENST00000415599ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000415599ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000415599ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000415599ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000415599ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000415599ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000415599ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
5CDS-intronENST00000415599ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000345125ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000345125ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000345125ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000345125ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000345125ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000345125ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000345125ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000345125ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000345125ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000533455ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000533455ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000533455ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000533455ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000533455ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000533455ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000533455ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000533455ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000533455ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000534510ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000534510ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000534510ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000534510ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000534510ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000534510ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000534510ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000534510ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000534510ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000525076ENST00000318789CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-3UTRENST00000525076ENST00000475937CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000525076ENST00000493089CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000525076ENST00000484350CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000525076ENST00000318779CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000525076ENST00000491238CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000525076ENST00000498215CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000525076ENST00000468577CTSBchr8

11701829

-FOXP1chr3

71007472

-
intron-intronENST00000525076ENST00000472382CTSBchr8

11701829

-FOXP1chr3

71007472

-

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FusionProtFeatures for CTSB_FOXP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTSB

P07858

FOXP1

Q9H334

Thiol protease which is believed to participate inintracellular degradation and turnover of proteins. Has also beenimplicated in tumor invasion and metastasis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTSB_FOXP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTSB_FOXP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTSBCSTA, CSTB, CST3, BAG6, S100A10, ANXA2, UBQLN4, USP29, DMWD, FAM118B, SPRY2, CDKN1A, RGS2, ANXA7, SH3KBP1, APP, PROCR, PARP1, MLH1, METTL21B, HNRNPD, XRN1, HIPK4, CDK18, FBXO6, IRS4, UNK, MSI2, HSPB2, STK11, CEP164, FBF1, RPGRIP1L, SCLT1, CDH1, PTPN18, NR3C1, TRIM25FOXP1CTBP1, FOXP1, FOXP2, FOXP4, GATAD2B, MTA1, NCOR2, ELAVL1, MYC, IL3RA, CCDC183, UNK, RCC1, HOXD13, QSER1, SATB1, SATB2, CTBP2, MYH10, LIG3, C10orf2, CUX1, VRK3, XRCC1, CHD1L, RPA2, BLM, MRE11A, MYL12B, TBP, TP53, TTF2, ZBTB10, MYL9, RPA3, TFCP2, TOP2A, UBP1, FOXP3, AURKA, SNRNP70


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTSB_FOXP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTSB_FOXP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTSBC0027626Neoplasm Invasiveness2CTD_human
HgeneCTSBC0007134Renal Cell Carcinoma1CTD_human
HgeneCTSBC0017636Glioblastoma1CTD_human
HgeneCTSBC0026848Myopathy1CTD_human
HgeneCTSBC0027540Necrosis1CTD_human
HgeneCTSBC0033578Prostatic Neoplasms1CTD_human
HgeneCTSBC0033687Proteinuria1CTD_human
TgeneFOXP1C0024232Lymphatic Metastasis1CTD_human
TgeneFOXP1C0027626Neoplasm Invasiveness1CTD_human
TgeneFOXP1C0030297Pancreatic Neoplasm1CTD_human
TgeneFOXP1C0042900Vitiligo1CTD_human
TgeneFOXP1C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneFOXP1C1510586Autism Spectrum Disorders1CTD_human
TgeneFOXP1C3495559Juvenile arthritis1CTD_human
TgeneFOXP1C4013764MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES1CTD_human;ORPHANET;UNIPROT