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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8886

FusionGeneSummary for CTRC_GABBR1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTRC_GABBR1
Fusion gene ID: 8886
HgeneTgene
Gene symbol

CTRC

GABBR1

Gene ID

11330

10537

Gene namechymotrypsin Cubiquitin D
SynonymsCLCR|ELA4FAT10|GABBR1|UBD-3
Cytomap

1p36.21

6p22.1

Type of geneprotein-codingprotein-coding
Descriptionchymotrypsin-Ccaldecrinelastase 4elastase IVserum calcium decreasing factorubiquitin Ddiubiquitinubiquitin-like protein FAT10
Modification date2018052020180523
UniProtAcc

Q99895

Q9UBS5

Ensembl transtripts involved in fusion geneENST00000375949, ENST00000375943, 
ENST00000483406, 		ENST00000355973, 
ENST00000376977, ENST00000377016, 
ENST00000377012, ENST00000377034, 
ENST00000449163, ENST00000452300, 
ENST00000547410, ENST00000546913, 
ENST00000550428, ENST00000489750, 
ENST00000419674, ENST00000439457, 
ENST00000438094, ENST00000548767, 
ENST00000486623, ENST00000434660, 
ENST00000423604, ENST00000414980, 
ENST00000417759, ENST00000551140, 
ENST00000446436, ENST00000471103, 
ENST00000443440, ENST00000425097, 
ENST00000383543, ENST00000552399, 
ENST00000383537, ENST00000493602, 
ENST00000383541, ENST00000383542, 
ENST00000383639, ENST00000551423, 
ENST00000383636, ENST00000495153, 
ENST00000383637, ENST00000383638, 
ENST00000448754, ENST00000550820, 
ENST00000458612, ENST00000464091, 
ENST00000440316, ENST00000418225, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: CTRC [Title/Abstract] AND GABBR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGABBR1

GO:0006511

ubiquitin-dependent protein catabolic process

17889673

TgeneGABBR1

GO:0016567

protein ubiquitination

15831455|17889673

TgeneGABBR1

GO:0070842

aggresome assembly

19033385


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI835315CTRCchr1

15769008

+GABBR1chr6

873384

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375949ENST00000355973CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000376977CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000377016CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000377012CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000377034CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000449163CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000452300CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000547410CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000546913CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000550428CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000489750CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000419674CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000439457CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000438094CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000548767CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000486623CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000434660CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000423604CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000414980CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000417759CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000551140CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000446436CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-5UTRENST00000375949ENST00000471103CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000443440CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000425097CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000383543CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000552399CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000383537CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-5UTRENST00000375949ENST00000493602CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000383541CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000383542CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000383639CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000551423CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000383636CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-5UTRENST00000375949ENST00000495153CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000383637CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000383638CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375949ENST00000448754CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000550820CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000458612CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-5UTRENST00000375949ENST00000464091CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000440316CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375949ENST00000418225CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000355973CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000376977CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000377016CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000377012CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000377034CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000449163CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000452300CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000547410CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000546913CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000550428CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000489750CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000419674CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000439457CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000438094CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000548767CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000486623CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000434660CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000423604CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000414980CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000417759CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000551140CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000446436CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-5UTRENST00000375943ENST00000471103CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000443440CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000425097CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000383543CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000552399CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000383537CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-5UTRENST00000375943ENST00000493602CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000383541CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000383542CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000383639CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000551423CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000383636CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-5UTRENST00000375943ENST00000495153CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000383637CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000383638CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-intronENST00000375943ENST00000448754CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000550820CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000458612CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-5UTRENST00000375943ENST00000464091CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000440316CTRCchr1

15769008

+GABBR1chr6

873384

-
5CDS-3UTRENST00000375943ENST00000418225CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000355973CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000376977CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000377016CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000377012CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000377034CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000449163CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000452300CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000547410CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000546913CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000550428CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000489750CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000419674CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000439457CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000438094CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000548767CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000486623CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000434660CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000423604CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000414980CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000417759CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000551140CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000446436CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-5UTRENST00000483406ENST00000471103CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000443440CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000425097CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000383543CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000552399CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000383537CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-5UTRENST00000483406ENST00000493602CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000383541CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000383542CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000383639CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000551423CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000383636CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-5UTRENST00000483406ENST00000495153CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000383637CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000383638CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-intronENST00000483406ENST00000448754CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000550820CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000458612CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-5UTRENST00000483406ENST00000464091CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000440316CTRCchr1

15769008

+GABBR1chr6

873384

-
3UTR-3UTRENST00000483406ENST00000418225CTRCchr1

15769008

+GABBR1chr6

873384

-

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FusionProtFeatures for CTRC_GABBR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTRC

Q99895

GABBR1

Q9UBS5

Regulates activation and degradation of trypsinogens andprocarboxypeptidases by targeting specific cleavage sites withintheir zymogen precursors. Has chymotrypsin-type protease activityand hypocalcemic activity. {ECO:0000269|PubMed:23430245}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTRC_GABBR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTRC_GABBR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CTRC_GABBR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGABBR1Q9UBS5DB00181BaclofenGamma-aminobutyric acid type B receptor subunit 1small moleculeapproved
TgeneGABBR1Q9UBS5DB01080VigabatrinGamma-aminobutyric acid type B receptor subunit 1small moleculeapproved
TgeneGABBR1Q9UBS5DB00837ProgabideGamma-aminobutyric acid type B receptor subunit 1small moleculeapproved|investigational
TgeneGABBR1Q9UBS5DB00996GabapentinGamma-aminobutyric acid type B receptor subunit 1small moleculeapproved|investigational

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RelatedDiseases for CTRC_GABBR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTRCC0149521Pancreatitis, Chronic1CTD_human
HgeneCTRCC0238339Hereditary pancreatitis1CTD_human;ORPHANET;UNIPROT
TgeneGABBR1C0001973Alcoholic Intoxication, Chronic5CTD_human;PSYGENET
TgeneGABBR1C0004352Autistic Disorder2CTD_human
TgeneGABBR1C0036341Schizophrenia2PSYGENET
TgeneGABBR1C0236736Cocaine-Related Disorders1CTD_human
TgeneGABBR1C0424295Hyperactive behavior1CTD_human